Intracranial hemorrhages associated with meningiomas: Own experience and literature review

Siedlecki, Zygmunt; Nowak, Karol; Grzyb, Sebastian; Śniegocki, Maciej

doi:10.4103/jcrt.jcrt_958_20

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…In most PPM cases, an asymptomatic pulmonary nodule may emerge, with only three reported cases with hemoptysis [ 7 , 8 ]. Notably, complications related to hemorrhage, occurring in approximately 2.2% of patients with intracranial meningioma, are often attributed to the rupture of defective intratumoral blood vessels and overstretched veins surfacing the growing tumor [ 9 ]. In cases of lung cancer, hemoptysis can occur through various mechanisms, including neovascularization in and around the tumor, invasion of vascular structures by the tumor, exfoliation of the tumor surface, and tumor necrosis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Rapid growth of primary pulmonary meningioma with hemoptysis

Tamenaga,

Kawaguchi,

Kogami

et al. 2024

Oxford Medical Case Reports

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While lung cancer is the predominant neoplasm causing hemoptysis, rare benign neoplasms can also be associated with hemoptysis. A 60-year-old woman presented with cough and hemoptysis. Chest computed tomography revealed an oval-shaped, well-circumscribed solitary mass (10 cm in size) in the right lower lobe, which had grown rapidly over the past year. The presence of intramass air bubbles and a surrounding halo of ground-glass opacities suggested the hemorrhagic rupture of a circumscribed hematoma into the surrounding lung tissue. Subsequent right lower lobectomy revealed a well-demarcated hematoma; its wall consisted of nonatypical spindle tumor cells, which were histologically diagnosed as meningioma. No meningioma was observed in the central nervous system, leading to the diagnosis of primary pulmonary meningioma. This case highlights PPM as a rare benign tumor (World Health Organization grade 1) capable of rapid development due to intratumoral hemorrhage, presenting with hemoptysis.

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Section: Discussionmentioning

confidence: 99%

Rapid growth of primary pulmonary meningioma with hemoptysis

Tamenaga,

Kawaguchi,

Kogami

et al. 2024

Oxford Medical Case Reports

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“…Meningiomas are one of the most common benign tumors [ 11 ]. Intratumoral hemorrhage in meningiomas is very rare, with a reported prevalence of 0.5-2.3% [ 12 ] or 2.2% [ 13 ]. Additionally, 67.9% of hemorrhagic meningiomas have been reported to be located in the convexity region, 50% presenting as intracerebral hemorrhage, and 27.3% as subdural hematoma [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, 67.9% of hemorrhagic meningiomas have been reported to be located in the convexity region, 50% presenting as intracerebral hemorrhage, and 27.3% as subdural hematoma [ 14 ]. The cause of intratumoral hemorrhage is unclear; however, it is thought to be caused by disruption of tumor vessels, disruption of bridging veins due to growing tumors [ 13 ], and venous infarction due to venous obstruction with cerebral edema [ 15 ]. Moreover, previous studies have reported that meningiomas with intratumoral hemorrhage are often WHO grade I [ 13 , 14 ] and that the risk factors for intratumoral hemorrhage include age >70 years, hypertension, anticoagulant therapy, trauma, serotonin regulation therapy, and high-volume estrogen replacement therapy [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Rare Intratumoral Hemorrhage Following COVID-19 Vaccination

Sugasawa¹,

Kimura²,

Bae³

et al. 2022

Cureus

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The increase in the rate of mRNA vaccination against coronavirus disease 2019 (COVID-19) worldwide has been accompanied by reports of an increase in the side effects of the vaccine. In the field of neurosurgery, several cases of venous thrombosis have been reported as possible complications after COVID-19 vaccination. However, no such side effects have been reported in patients with brain tumors, and COVID-19 vaccination is considered safe for this patient population. In this report, we present the cases of two patients with brain tumors who experienced intratumoral hemorrhage as a possible side effect of the COVID-19 vaccine. In the first case, a 54-year-old man who had received CyberKnife treatment for a vestibular schwannoma eight years prior presented with tongue discomfort, right-side facial numbness, and dizziness since the day after his COVID-19 vaccination. MRI revealed intratumoral hemorrhage of the vestibular schwannoma. The second patient was a 60-year-old woman who presented with a sudden-onset headache and vomiting that had started three days after her COVID-19 vaccination. CT revealed a meningioma with intratumoral hemorrhage. Both patients had undergone surgery prior to this presentation, and their symptoms had improved. They had no risk factors for intratumoral hemorrhage, suggesting that it may be a side effect of the mRNA vaccine against COVID-19. Although the causal relationship is unclear, acute inflammation with predominantly lymphocytic infiltration and thrombogenicity after COVID-19 vaccination may damage the fragile microcirculation of the tumor.

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“… 2 Intratumoural haemorrhage occurs commonly in high grade gliomas and oligodendrogliomas but they have been also reported to occur in pituitary adenomas, meningiomas, pilocytic astrocytomas, hemangiomas and in cerebral metastasis. 3 , 4 , 5 , 6 , 7 Bleeding within the tumour occurs most likely due to tumour vascularization, neovascularization with microvascular proliferation and hyperplasia of endothelial cells along with poorly formed dilated vessels predisposing to haemorrhage within the tumour. 8 Haemorrhage within intracranial germ cell tumours (iGCTs) are exceedingly rare, reported mostly in cases of mixed germ cell tumours and choriocarcinomas.…”

Section: Introductionmentioning

confidence: 99%

Intratumoural haemorrhage in intracranial germ cell tumours: A review of literature with an illustrative case

Datta,

Ghosh,

Hazra

et al. 2024

World Neurosurgery: X

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Intracranial hemorrhages associated with meningiomas: Own experience and literature review

Cited by 8 publications

References 20 publications

Rapid growth of primary pulmonary meningioma with hemoptysis

Rapid growth of primary pulmonary meningioma with hemoptysis

Two Cases of Rare Intratumoral Hemorrhage Following COVID-19 Vaccination

Intratumoural haemorrhage in intracranial germ cell tumours: A review of literature with an illustrative case

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