Intracranial Hemorrhage in Asymptomatic Neonates: Prevalence on MR Images and Relationship to Obstetric and Neonatal Risk Factors

Looney, Christopher B.; Ja, Smith; Merck, Lisa H.; Wolfe, Honor M.; Chescheir, Nancy C.; Hamer, Robert M.; Gilmore, John H.

doi:10.1148/radiol.2422060133

Cited by 291 publications

(200 citation statements)

References 39 publications

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“…16 However, MRI revealed that asymptomatic SDH at birth is common. [17][18][19] Some studies report a prevalence as high as 50%, 20 although no study so far reports persistence of SDH present at birth beyond 4 weeks. 21 The purpose of this study was to review the incidence of SDH in newborns with congenital heart disease undergoing MRI brain scans as part of a perioperative research protocol and to explore the relationship between SDH and hypoxia.…”

Section: Resultsmentioning

confidence: 99%

“…The rate of asymptomatic neonatal SDH in published literature ranges from 8% to 45%. [17][18][19]21 One previous study of SDH in a much smaller cohort of newborns with congenital heart disease identified preoperative SDH in 11 out of 21 (52%). 20 It is usually suggested that these SDHs originate from tearing of the dura or bridging veins by molding of the cranium during birth.…”

Section: Discussionmentioning

confidence: 99%

“…20 It is usually suggested that these SDHs originate from tearing of the dura or bridging veins by molding of the cranium during birth. [17][18][19][23][24][25] Others suggest that they originate from "intradural bleeding or congestion of the abundant venous sinuses" rather than from torn bridging veins. 14 The location of the SDH seen in our cohort was diverse.…”

Section: Discussionmentioning

confidence: 99%

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Subdural Hemorrhage and Hypoxia in Infants With Congenital Heart Disease

Kelly

Hayman²,

Shekerdemian

et al. 2014

Pediatrics

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BACKGROUND AND OBJECTIVES: It has been suggested that there is a causal relationship between hypoxia and subdural hemorrhage (SDH) in infancy. The purpose of this study was to review the incidence of SDH in infants with congenital heart disease and explore the relationship between SDH and hypoxia. METHODS: Review of data collected for a prospective longitudinal cohort study of infants undergoing surgery for congenital heart disease in New Zealand and Australia. Infants underwent serial MRI scans of the brain in the first 3 months of life. All oxygen saturation recordings and MRI results were extracted and infants assigned to categories by degree of hypoxia. The data were then examined for any statistically significant relationship between hypoxia and SDH. RESULTS: One hundred fifty-two infants underwent MRI scans, and 66 (43%) had 145 loci of SDH. New SDH was seen in 12 infants after cardiac surgery. Of the loci of SDH, 63 (43%) were supratentorial, and most of these were interhemispheric, parietal, or temporal. SDH present on the first MRI persisted beyond 28 days of life in 8 infants. There was no demonstrable relationship between SDH and hypoxia. CONCLUSIONS: Asymptomatic SDH is common in young infants with congenital heart disease, at a frequency similar to that of those without congenital heart disease. These SDHs may occur in locations where they occur in abusive head trauma, but they are typically small and resolve within 3 months of birth. We were unable to demonstrate any association between hypoxia and SDH in this cohort.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Subdural Hemorrhage and Hypoxia in Infants With Congenital Heart Disease

Kelly

Hayman²,

Shekerdemian

et al. 2014

Pediatrics

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“…Pregnant women were recruited from the outpatient obstetrics−gynecology clinics at the University of North Carolina hospitals and Duke University Medical Center. Exclusion criteria for mothers included major maternal illness or infection during pregnancy, and maternal diagnosis of a major psychiatric disorder; for neonates, exclusion criteria included chromosomal abnormalities, severe congenital abnormalities, major medical illness or infection, and abnormalities on MRI other than small intracranial hemorrhages that are common in neonates (38). Zygosity was determined with PCR short tandem repeat analysis of 14 loci on DNA prepared from buccal swab cell collection (BRT Laboratories).…”

Section: Methodsmentioning

confidence: 99%

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Lee

Steiner

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Previous studies indicate that the microstructure of individual white matter (WM) tracts is related to cognitive function. More recent studies indicate that the microstructure of individual tracts is highly correlated and that a property common across WM is related to overall cognitive function in adults. However, little is known about whether these common WM properties exist in early childhood development or how they are related to cognitive development. In this study, we used diffusion tensor imaging (DTI) to investigate common underlying factors in 12 fiber tracts, their relationship with cognitive function, and their heritability in a longitudinal sample of healthy children at birth (n = 535), 1 y (n = 322), and 2 y (n = 244) of age. Our data show that, in neonates, there is a highly significant correlation between major WM tracts that decreases from birth to 2 y of age. Over the same period, the factor structure increases in complexity, from one factor at birth to three factors at age 2 y, which explain 50% of variance. The identified common factors of DTI metrics in each age group are significantly correlated with general cognitive scores and predict cognitive ability in later childhood. These factors are moderately heritable. These findings illustrate the anatomical differentiation of WM fiber from birth to 2 y of age that correlate with cognitive development. Our results also suggest that the common factor approach is an informative way to study WM development and its relationship with cognition and is a useful approach for future imaging genetic studies.factor analysis | white matter | DTI | cognition | heritability I ndividual differences in white matter (WM) microstructure have been shown to be related to cognitive functions in adults (1, 2) and children (3-5). Diffusion tensor imaging (DTI) parameters in different WM regions or tracts are variably associated with processing speed, general intelligence, and higher-order cognitive abilities (1-5).To date, the majority of DTI studies of WM microstructure have analyzed each tract or WM region independently. However, more recent studies clearly demonstrate that fractional anisotropy (FA) and other DTI metrics of WM microstructure correlate highly across WM tracts and across a wide age range, including neonates, older children, and adults (6-8). Furthermore, studies indicate that a general factor derived by principal component analyses (PCA) describing common variance in FA across WM tracts is associated with information processing speed (9) as well as general intelligence (10), at least in older adults. In children ages 8 to 16 y, three principal components of FA have been identified; the one corresponding to the corpus callosum was significantly related to IQ (11).The identification of one or more common WM factors that influence variation in multiple WM tracts or regions is important for several reasons. Such factors could prove to be a good target for imaging genetic studies, as one would expect genetic variants influencing WM development and function ...

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“…ICH following vaginal delivery in full-term infants has been shown to have a prevalence as high as 26%, of which intraparenchymal hemorrhage has been shown to be the second most common cause, following subdural hemorrhage. 8 Symptomatic spontaneous intraparenchymal hemorrhage is thought to be extremely rare in full-term newborns and literature available on this is limited. Sandberg et al identified no underlying cause in more than 50% of fullterm neonates with spontaneous intracranial hemorrhage.…”

mentioning

confidence: 99%

Intracranial Hemorrhage resulting in Apneic Seizures in a Full-term infant: A Case Report and Review of Literature

Winkler¹,

Tarabishy²,

Marcus³

2017

WVMJ

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Symptomatic spontaneous intracranial hemorrhage is rare in term neonates and the literature available on this subject is limited. In this case report, we present the clinical presentation, imaging findings and clinical course of a term neonate with neonatal seizures who was found to have intracranial hemorrhage. The available literature on this has been briefly reviewed and imaging findings and management of these newborns has been discussed in brief.

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Intracranial Hemorrhage in Asymptomatic Neonates: Prevalence on MR Images and Relationship to Obstetric and Neonatal Risk Factors

Abstract: Asymptomatic ICH following vaginal birth in full-term neonates appears to be common, with a prevalence of 26% in this study.

Cited by 291 publications

References 39 publications

Subdural Hemorrhage and Hypoxia in Infants With Congenital Heart Disease

Subdural Hemorrhage and Hypoxia in Infants With Congenital Heart Disease

Common and heritable components of white matter microstructure predict cognitive function at 1 and 2 y

Intracranial Hemorrhage resulting in Apneic Seizures in a Full-term infant: A Case Report and Review of Literature

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