Intracranial hemorrhage in an adult with factor‐VII deficiency

Seaborg, B. J.; Burns, C. Patrick; Olson, John D.; Pennell, Beverly J.; Follett, Kenneth A.

doi:10.1002/ajh.2830450122

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…The authors recommended routine coagulation studies in all patients with SAH and factor VII determination in those displaying normal PTT and prolonged PT. However, the only case with underlying vascular anomaly has been reported by SEABORG et al [13]: cerebral angiogram disclosed a 2-3 ram, deep angioma in an 18 year old boy presenting with large basal ganglia hemorrhage and factor VII activity Of 36 %. The patient was treated conservatively.…”

Section: Discussionmentioning

confidence: 90%

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Successful excision of hemorrhagic cavernous angioma in a patient with severe factor VII deficiency: Perioperative treatment with factor VII concentrate

et al. 1997

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A case of an uncomplicated neurosurgical procedure in a patient affected by a rare bleeding disorder is described. The interest is twofold: first because of the possible influence of underlying coagulopathy in disclosing the vascular anomaly. And second although surgery in factor VII deficiency has been reported before, with and without replacement therapy, to our knowledge, this is the first neurosurgical case in which factor VII concentrate was used. This treatment allowed safe surgery and protected the patient from complications associated with plasma and protrombin complex use.

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Section: Discussionmentioning

confidence: 90%

“…On the other hand, adult cases are exceptional [8,13], the subarachnoid space being the most common site of bleeding. PAPA et al [10] recently described two female patients affected by factor VII deficiency, presenting with SAH and negative pan-angiography.…”

Section: Discussionmentioning

confidence: 97%

Successful excision of hemorrhagic cavernous angioma in a patient with severe factor VII deficiency: Perioperative treatment with factor VII concentrate

et al. 1997

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“…14, 15 Subdural hematoma unrelated to external trauma has been reported infrequently in adults with hereditary factor VII deficiency but was the presenting manifestation in 1 case. 1,2 The hemorrhagic diathesis of the present patient may have increased his risk to develop SDH by diminishing hemostasis at sites of pressure-induced intracranial vascular injury. We were unable to identify previous reports of Valsalva-associated or inversion-associated intracranial hemorrhage in persons with hereditary deficiencies of coagulation factors.…”

Section: Discussionmentioning

confidence: 96%

Bilateral Subdural Hematomas in an Adult With Hereditary Factor VII Deficiency: A Complication of Sit-ups and Inversion?

Barton

Bertoli²,

O’Malley³

2007

Clin Appl Thromb Hemost

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A 57-year-old man of northern Italian and Polish descent with a late-onset, mild form of hereditary factor VII deficiency developed bilateral intracranial subdural hematomas after performing sit-ups while he was in a head-down position on an inversion table. The pertinence of the Valsalva maneuver and increased intracranial venous and intraocular pressure associated with sit-ups and other exercises in the causation of subdural hematomas and other types of intracranial and ocular hemorrhage are discussed in this study.

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“…Isolated factor VII deficiency is often discovered after an isolated brain haemorrhage, when the bleeding tendency is manifested together with markedly decreased factor VII activity. 7,10 The patient's brain haemorrhage may have been triggered by hypertension, since maintaining normal blood pressure was found to ameliorate his clinical symptoms. Isolated factor VII deficiencies are rare, so we examined the patient's plasma for the presence of an inhibitor of factor VII activity but no autoantibody induced factor VII inhibitor was present.…”

Section: Discussionmentioning

confidence: 99%

Isolated Factor VII Deficiency Diagnosed after a Life-Threatening Brain Haemorrhage

Tsuda¹,

Okamoto²,

Sakaguchi³

et al. 2000

J Int Med Res

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A 65-year-old man was admitted to another hospital with a life-threatening brain haemorrhage, and laboratory examinations on admission revealed prolonged prothrombin time with normal activated partial thromboplastin time. To establish the cause of his abnormal coagulation, he was referred to our clinic. Neither the patient nor his family had any previous history of bleeding symptoms. His liver function was within normal limits but coagulation tests showed increased plasma activities of factors II, VIII, IX, X, with reduced activities of factors V and VII. The activity of factor VII was less than 2% but no inhibitor of factor VII was detected in the plasma. We concluded that the patient had a rare congenital isolated factor VII deficiency although he had not shown earlier bleeding problems, presumably because of compensation for the factor VII deficiency by enhanced activities of components of the extrinsic coagulation pathway, factors II, VIII, IX and X.

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Intracranial hemorrhage in an adult with factor‐VII deficiency

Cited by 6 publications

References 7 publications

Successful excision of hemorrhagic cavernous angioma in a patient with severe factor VII deficiency: Perioperative treatment with factor VII concentrate

Successful excision of hemorrhagic cavernous angioma in a patient with severe factor VII deficiency: Perioperative treatment with factor VII concentrate

Bilateral Subdural Hematomas in an Adult With Hereditary Factor VII Deficiency: A Complication of Sit-ups and Inversion?

Isolated Factor VII Deficiency Diagnosed after a Life-Threatening Brain Haemorrhage

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