Intracranial hemorrhage caused by dabrafenib and trametinib therapy for metastatic melanoma
Aymeric Hennemann,
Eve Puzenat,
Marion Decreuse
et al.
Abstract:Although generally well tolerated compared with chemotherapy, molecular targeted therapy used in metastatic melanoma may be associated with life-threatening toxicity. We report the case of a patient with metastatic melanoma treated by dabrafenib plus trametinib who developed intracranial hemorrhage. Physicians should be aware of this rare but life-threatening adverse event of B-rapidly accelerated fibrosarcoma (BRAF) and mitogen-activated protein kinase kinase (MEK). However, they should be careful about the b… Show more
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