Intracranial Hemangiopericytoma: Treatment Outcomes in a Consecutive Series

Bassiouni, Hischam; Asgari, Siamak; Hübschen, Uwe; König, H.-J.; Stolke, D.

doi:10.1055/s-2007-981674

Cited by 27 publications

(19 citation statements)

References 28 publications

(104 reference statements)

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“…7)2,18). Interestingly, the average mortality rate in the recent literature was 31.5%1,2,15,16,18,21,28,35,37,42,44), but was only 15.4% in our study. Though adjuvant therapy and follow-up period also affect the mortality rate, we cautiously suggest that GTR also contributed to the decreased mortality rate.…”

Section: Discussioncontrasting

confidence: 67%

“…We conducted a statistical analysis about correlation between extent of resection and recurrence, and we found statistical significance like other several series (mean RFS 105.7 months vs. 24.6 months, p =0.012) (Fig. 7)2,18). Interestingly, the average mortality rate in the recent literature was 31.5%1,2,15,16,18,21,28,35,37,42,44), but was only 15.4% in our study.…”

Section: Discussionsupporting

confidence: 65%

“…A Simpson grade I resection has been found to be associated with a high long-term control rate2,18). Similarly, Rutkowski et al36) reported that, regardless of adjuvant therapy, GTR was associated with significantly improved survival rates compared with PR.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Analysis of Intracranial Hemangiopericytoma

Park

Kim

Hong

et al. 2013

J Korean Neurosurg Soc

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ObjectiveIntracranial hemangiopericytomas (HPCs) are rare tumors with aggressive behavior, including local recurrence and distant metastasis. We conducted this retrospective study to evaluate the efficacy of grossly total resection and adjuvant radiotherapy (RT) for these tumors.MethodsA total of 13 patients treated for intracranial HPC from January 1995 through May 2013 were included in this retrospective study. We analyzed the clinical presentations, radiologic appearances, treatment results, and follow-up outcomes, as well as reviewed other studies.ResultsThe ages of the patients at the time of diagnosis ranged from 26 to 73 years (mean : 48 years). The majority of the patients were male (92.3%), and the majority of the tumors were located in the parasagittal and falx. The ratio of intracranial HPCs to meningiomas was 13 : 598 in same period, or 2.2%. Seven patients (53.8%) had anaplastic HPCs. Nine patients (69.2%) underwent gross total tumor resection in the first operation without mortality. Eleven patients (84.6%) underwent postoperative adjuvant RT. Follow-up period ranged from 13 to 185 months (mean : 54.3 months). The local recurrence rate was 46.2% (6/13), and there were no distant metastases. The 10-year survival rate after initial surgery was 83.9%. The initial mean Karnofsky performance scale (KPS) was 70.8 and the final mean KPS was 64.6.ConclusionGross total tumor resection upon initial surgery is very important. We believe that adjuvant RT is helpful even with maximal tumor resection. Molecular biologic analyses and chemotherapy studies are required to achieve better outcomes in recurrent intracranial HPCs.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionsupporting

confidence: 65%

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Clinical Analysis of Intracranial Hemangiopericytoma

Park

Kim

Hong

et al. 2013

J Korean Neurosurg Soc

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“…The extent of resection has previously been shown to correlate strongly with outcome on UVAs, with most suggesting the extent of resection as the most important prognostic factor. [10][11][12][13] In addition, we report an improvement in OS and CSS on MVA with the use of postoperative RT. The published data consist mostly of single-institution retrospective data that are conflicting.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the rarity of the diagnosis, available data widely consist of institutional retrospective studies. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] As such, the optimal management of intracranial HPC is debated. Recent publications have questioned the role of radiotherapy (RT) in the management of intracranial HPC.…”

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confidence: 99%