Intracranial Hemangiopericytoma—Our Experience in 30 Years: A Series of 43 Cases and Review of the Literature

Melone, A; D’Elia, Alessandro; Santoro, Francesca; Salvati, Maurizio; Delfini, Roberto; Cantore, Giampaolo; Santoro, Antonio

doi:10.1016/j.wneu.2013.11.009

Cited by 117 publications

(118 citation statements)

References 30 publications

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“…In previous studies, older age has been reported to be associated with worse overall survival for CNS SFT/HPC and for soft tissue SFT . Other clinical features like exact tumor location and tumor volume also reportedly provide prognostic information . Unfortunately, data regarding these features were only available for a limited subset of cases in our cohort and therefore could not be statistically analyzed.…”

Section: Discussionsupporting

confidence: 92%

Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

et al. 2018

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The finding that meningeal solitary fibrous tumors (SFTs) and meningeal hemangiopericytomas (HPCs) are both characterized by NAB2-STAT6 gene fusion has pushed their inclusion in the WHO 2016 Classification of tumors of the central nervous system (CNS) as different manifestations of the same entity. Given that the clinical behavior of the CNS SFT/HPC spectrum ranges from benign to malignant, it is presently unclear whether the grading criteria are still adequate. Here, we present the results of a study that analyzed the prognostic value of an updated version of the Marseille Grading System (MGS) in a retrospectively assembled cohort of 132 primary meningeal SFTs/HPCs with nuclear overexpression of STAT6. The median patient follow-up was 64 months (range 4-274 months); 73 cases (55%) were MGS I, 50 cases (38%) MGS II and 9 cases (7%) were MGS III. Progression-free survival (PFS) and disease-specific survival (DSS) were investigated using univariate analysis: the prognostic factors for PFS included MGS, extent of surgery, radiotherapy, chemotherapy and mitotic activity ≥5/10 high-power field (HPF). Moreover, MGS, radiotherapy, mitotic activity ≥5/10 HPF, and necrosis were the prognostic factors measured for DSS. In multivariate analysis, extent of surgery, mitotic activity ≥5/10 HPF, MGS I and MGS III were the independent prognostic factors measured for PFS while necrosis, MGS III and radiotherapy were the independent prognostic factors for DSS. In conclusion, our results show that assessing the malignancy risk of SFT/HPC should not rely on one single criterion like mitotic activity. Therefore, MGS is useful as it combines the value of different criteria. In particular, the combination of a high mitotic activity and necrosis (MGS III) indicates a particularly poor prognosis.

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Section: Discussionsupporting

confidence: 92%

Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

et al. 2018

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“…When gross total removal is achieved, a better prognosis can be anticipated. [814] However, when found in the foramen magnum, which is surrounded by many vital neuronal and vascular structures, removal is more difficult. [1118] For such tumors, several approaches including the lateral suboccipital approach, transoral approach, transcervical, and far-lateral approach have been described previously.…”

Section: Introductionmentioning

confidence: 99%

A case report of surgical management of hemangiopericytoma at the foramen magnum

et al. 2017

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Background:Hemangiopericytoma (HPC) is a highly vascularized mesenchymal tumor known for its high rates of recurrence and metastasis. The extent of tumor removal is known to be the most trustful prognostic factor. Skull base HPCs are challenging to treat because of the difficulty of the surgical approach and proximity to vital vascular and neuronal structures. We successfully treated a case of HPC at the ventral foramen magnum through surgical gross tumor removal via a far-lateral transcondylar approach.Case Description:A 38-year-old male complained of neck pain and bilateral paresthesia of his shoulders for 2 months, for which he was referred to our hospital. A magnetic resonance image (MRI) showed a 20 mm diameter mass at the ventral foramen magnum, which compressed his medulla oblongata. The tumor was gross totally removed via a far-lateral transcondylar approach. During the surgery, marked bleeding disturbed the surgical field until the main feeding artery from the direction of the dura mater was coagulated and cut. A relatively wide surgical field and a transcondylar approach were helpful to control the bleeding. The pathological examination revealed the tumor to be a HPC. After an uneventful recovery period of 9 days, the patient was discharged without neurological sequelae.Conclusion:We successfully and completely removed an HPC near the foramen magnum, employing a wide surgical field and a transcondylar approach to help control bleeding. When the tumor is suspected preoperatively to be a hemangiocytoma or vascular-rich tumor, a surgical approach that can secure a wide surgical field should be selected.

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“…С риском раннего рецидивирования также были ассоциированы размер опухоли не менее 7 см (р <0,05) и вовлечение синуса (р <0,05). С улучшением показателей общей выживаемости был ассоциирован наибольший объем резекции (р <0,05), а с худшими показателями общей выживаемости и периода до раз-вития рецидива -анапластическая форма гемангиопе-рицитомы (G3) [23].…”

Section: лучевая терапия менингеальных гемангиоперицитомunclassified

Radiation Therapy of Meningeal Hemangiopericytomas (Literature Review and Clinical Observation)

Nazarenko¹,

Borisova²,

Medvedev³

et al. 2017

Opuholi golovy šei

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Intracranial Hemangiopericytoma—Our Experience in 30 Years: A Series of 43 Cases and Review of the Literature

Cited by 117 publications

References 30 publications

Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients

A case report of surgical management of hemangiopericytoma at the foramen magnum

Radiation Therapy of Meningeal Hemangiopericytomas (Literature Review and Clinical Observation)

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