Intracranial germ cell tumors: a retrospective study of 44 children

Jaing, Tang‐Her; Wang, Huei-Shyong; Hung, Iou‐Jih; Tseng, Chen‐Kan; Yang, Chao-Ping; Hung, Po-Cheng; Lui, Tai Ngar

doi:10.1016/s0887-8994(01)00419-2

Cited by 26 publications

(7 citation statements)

References 19 publications

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“…Several groups have reported that only tumor histology predicts outcome for tumors in the pineal region (i.e., NGGCTs), whereas patient age, gender, type of surgical procedure, radiotherapy field and tumor dose do not. The same groups have also reported that definitive radiotherapy may control germinomas, but that a more aggressive approach is required for local control of NGGCTs; they further recommend that WBRT or CSI be considered for locally advanced tumors (4,18,19). In one review of 32 patients with NGGCT, tumor histology and the use of CSI predicted relapse-free survival and CSI was found to be significantly associated with OS.…”

Section: Discussionmentioning

confidence: 99%

“…NGGCTs and mixed GCTs often consist of one or more histopathological subtypes, such as mature teratoma, immature teratoma, teratoma with malignant transformation, embryonal carcinoma, yolk sac tumor and choriocarcinoma. Cranial NGGCTs are generally associated with worse outcomes compared to cranial germinomas (4). Surgery followed by radiochemotherapy has achieved excellent survival rates for patients with intracranial germinomas (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

Huo

Wang

Allen

et al. 2014

Molecular and Clinical Oncology

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The aim of this study was to evaluate the predictors of long-term survival following postoperative therapy for suprasellar germ cell tumors (GCTs). A total of 23 patients with pathologically confirmed suprasellar GCTs were reviewed between April, 1987 and October, 2008. The predictors were identified with a univariate Cox proportional hazards model and the results were used to group patients according to outcome. The overall survival (OS) and progression-free survival (PFS) rates for the good- and poor-prognosis two groups were estimated with Kaplan-Meier analysis, with log-rank tests used to assess differences between the groups. The OS rate for all patients was 82.6% at 5 and 72.9% at 10 years. Lesion size (2-4 vs. >4 cm) and pathological type (pure germinoma vs. mixed GCT) were the only significant predictors of OS (P<0.05). The OS rate for the good-prognosis group was 92.9% at both 5 and 10 years, whereas the corresponding rates for the poor-prognosis group were 66.7 and 40.0%, respectively (P=0.020). The PFS rate for the good-prognosis group was 92.9% at 5 and 85.7% at 10 years, whereas the corresponding PFS rates for the poor-prognosis group were 44.4 and 33.3%, respectively (P=0.007). Lesion size and histology predicted outcome following postoperative therapy for suprasellar GCT. Therefore, pathological diagnosis is recommended whenever possible, as histology may dictate the choice of treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

Huo

Wang

Allen

et al. 2014

Molecular and Clinical Oncology

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“…On the other hand, biopsy alone may not be helpful in obtaining the diagnosis of subtypes because GCTs are fre− quently heterogeneous tumors consisting of a mixture of sub− type components. Small biopsy specimens may therefore not re− present the entire lesion and may cause sampling error [2,3,7,10]. Diagnosis of subtypes and precise therapeutic strate− gies could be made later based on the results of the tumor mar− ker analyses together with the biopsy findings.…”

Section: Discussionmentioning

confidence: 99%

Management of Intracranial Germ Cell Tumors Presenting with Rapid Deterioration of Consciousness

Nishioka¹,

Haraoka²,

Miki³

2006

Minim Invasive Neurosurg

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“…In general, patients with germinoma have a better prognosis compared to patients with NGGCT [3,12] . The syncytiotrophoblastic variant of germinoma carries a less favourable prognosis than pure germinoma [4] .…”

Section: Prognostic Stratificationmentioning

confidence: 98%

Treatment Outcome in Patients with Primary Central Nervous System Germ Cell Tumour: Clinical Experience from a Regional Cancer Centre in North India

Biswas

Julka²,

Bakhshi³

et al. 2017

Pediatr Neurosurg

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Background: Primary intracranial germ cell tumour is a rare entity and constitutes 2-3% of all paediatric brain tumours in Western countries. We herein intend to report the clinical features and treatment outcome of patients with primary central nervous system germ cell tumour treated at our institute. Methods: Clinical data were collected by retrospective chart review from 2006 to 2012. Histopathology slides were reviewed and relevant immunohistochemistry stains were done. Overall survival (OS) and progression-free survival (PFS) were analysed by the Kaplan-Meier product-limit method. Results: Twenty patients met the study criterion (male:female = 7:3). Median age at presentation was 13 years. Tumour location was pineal in 10 patients, suprasellar in 6, thalamic in 2, basal ganglion in 1, and spinal in 1. Leptomeningeal spread was noted in 1 patient at presentation. Surgical resection was gross-total in 7 patients (35%), near-total in 2 (10%), subtotal in 4 (20%), and limited to biopsy in 6 (30%). The tumours were germinomatous, non-germinomatous, and of mixed germ cell subtype in 17 patients (85%), 2 patients (10%), and 1 patient (5%), respectively. Systemic chemotherapy (median of 4 cycles) was given to 19 patients (95%). The common regimens used were a combination of bleomycin, etoposide and cisplatin (BEP) in 14 patients (70%) and etoposide and cisplatin (EP) in 5 patients (25%). Radiation therapy (40-50 Gy in conventional fractionation; median of 42 Gy) was delivered to 17 patients (85%): local radiation in 6 and whole ventricular, whole brain, and craniospinal irradiation followed by a boost in 5, 3, and 3 patients, respectively. After a median follow-up of 44.52 months, 17 patients (85%) were in complete response and 3 (15%) had progressive disease. Death and disease recurrence were noted in 6 patients (30%) and 1 patient, respectively. Median OS and PFS were not reached. The actuarial rates of OS at 3 and 5 years were 75.8 and 68.9%, respectively. The actuarial rates of PFS at both 3 and 5 years were 81.6%. Conclusion: Multimodality treatment consisting of limited resection followed by platinum-based systemic chemotherapy and radiotherapy (40-50 Gy) is a reasonable treatment strategy in patients of primary central nervous system germ cell tumour in a developing nation.

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Intracranial germ cell tumors: a retrospective study of 44 children

Cited by 26 publications

References 19 publications

Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

Management of Intracranial Germ Cell Tumors Presenting with Rapid Deterioration of Consciousness

Treatment Outcome in Patients with Primary Central Nervous System Germ Cell Tumour: Clinical Experience from a Regional Cancer Centre in North India

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