Intracranial ganglioglioma: clinicopathological and MRI findings in 16 patients

Zhang, D.; Henning, TD; Zou, Liping; Hu, Lb-B.; Li, Wen; Feng, Xy-Y.; Dai, Sh-H.; Wang, Wx-X.; Sun, Qr-R.; Zhang, Zg-G.

doi:10.1016/j.crad.2007.06.010

Cited by 72 publications

(39 citation statements)

References 27 publications

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“…57,73 The majority of these tumors appear on T1-weighted MRI as isointense or hypointense lesions, hyperintense on T2-weighted MRI, and hyopintense on fluid-attenuated inversion recovery imaging. 4,7,73,97,98 Approximately 40% to 50% of patients with GG show calcifications on CT scans, whereas 50% to 60% of tumors contain cystic components. 3,4,6,98 Our analysis suggests that in the adult populations, GG have a slight predilection for the male gender with a 56% proportion (CI: 53-59%).…”

Section: Discussionmentioning

confidence: 98%

Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes

Yang

Chang

Han

et al. 2011

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 98%

Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes

Yang

Chang

Han

et al. 2011

Journal of Clinical Neuroscience

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“…17 There are no sex predilection, no specific location, and no classical radiological presentation. 18 The best treatment of anaplastic or malignant gangliogliomas is gross total resection followed by adjuvant radiotherapy and/or chemotherapy. 19 Temporal lobe location, chronic epilepsy, gross total resection, and absence of cellular atypia appear to be favorable prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1

et al. 2015

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Many aspects of this disease are still unknown. We identified a case of CMMRD in a patient presenting with an anaplastic ganglioglioma, who underwent successful surgical resection, chemotherapy, and radiotherapy and has had one of the longest survival periods known with this disease. This case broadens the tumor spectrum observed with CMMRD syndrome with anaplastic ganglioglioma and osteosarcoma as new phenotypic expressions of this genetic defect.

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“…Calcification was seen in 7 of the 13 cases (54%). The appearance of gangliogliomas has been reported to vary significantly on MRI, with 20–40% being hypointense and 40–70% being isodense on T1W MRI and 20–30% being isodense and 70–90% being hyperintense on T2W MRI [3], though one series found gangliogliomas to more often be hypointense than isodense on T1W MRI [31]. In the 12 gangliogliomas in which T1W MRI lesion intensity findings were reported, 3 (25%) lesions were hypointense, 4 (33%) were iso-intense, 3 (25%) were mixed density (25%), and 2 (17%) were partly hyperintense likely due to calcification.…”

Section: Discussionmentioning

confidence: 99%

“…Gangliogliomas are generally low-density lesions on CT with variable enhancement and calcification [4, 30, 31]. Of the 9 intraventricular gangliolgioma cases reporting lesion density, 1 (11%) was hyperdense, 5 (55%) were isodense, 2 (22%) were low-density, and 1 (13%) was mixed-density.…”

Section: Discussionmentioning

confidence: 99%

Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature

et al. 2019

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Background: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. Case Report: The patient initially presented at 9 months of age with a pilocytic astrocytoma centered on the optic chiasm, treated with chemotherapy and radiation at 3 years of age. Routine follow-up imaging at 13 years of age revealed the development of a mass in the septum pellucidum, which was subtotally resected endoscopically because of its proximity to the fornices. Pathology confirmed a ganglioglioma positive for the BRAF V600E mutation. The tumor residual progressed and was treated with stereotactic radiosurgery. The patient was asymptomatic at her 6-month follow-up visit and the size of the nodule remained stable. Literature Review: Our review of the 25 previously reported intraventricular gangliogliomas found that their pre-surgical diagnoses were often incorrect, reflecting the difficulty of making the diagnosis with signs, symptoms, and imaging alone. Patients can be reassured that the prognosis is generally favorable following uncomplicated neurosurgical resection.

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Intracranial ganglioglioma: clinicopathological and MRI findings in 16 patients

Cited by 72 publications

References 27 publications

Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes

Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomes

An Unusual Case of Constitutional Mismatch Repair Deficiency Syndrome With Anaplastic Ganglioglioma, Colonic Adenocarcinoma, Osteosarcoma, Acute Myeloid Leukemia, and Signs of Neurofibromatosis Type 1

Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature

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