Intracranial current density (LORETA) differences in QEEG frequency bands between depressed and non-depressed alcoholic patients

Coutin-Churchman, Pedro; Moreno, Rocío Segovia

doi:10.1016/j.clinph.2007.12.013

Cited by 25 publications

(14 citation statements)

References 55 publications

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“…In the current study, greater sgACC theta 2 activity was found in the MDD group; a similar trend was noted in BA25, part of the rostral ACC ( p =.11). Though this runs counter to some findings (Mientus et al, 2002; Coutin-Churchman & Moreno, 2008), our results are consistent with the idea that the ACC, particularly the rostral ACC, is implicated in emotive processing and cognitive control, and that elevated rostral ACC theta in MDD may reflect compensatory activity in fronto-cingulate networks in the disorder (Pizzagalli et al, 2011). In support of this, elevated baseline sgACC theta (Narushima et al, 2010) and rostral ACC theta has been shown to predict a positive antidepressant response (Pizzagalli et al, 2001; Mulert et al, 2007; Korb et al, 2011).…”

Section: Discussionsupporting

confidence: 70%

“…However, decreased frontal theta activity in MDD has been noted using source localization techniques [magnetoencephalography, low-resolution brain electromagnetic tomography (LORETA); Wienbruch et al, 2003; Coutin-Churchman & Moreno, 2008; Saletu et al, 2010]. Methodological differences may underlie these discrepancies, whereby frontal scalp theta amplitude/power likely stems from several neural generators, while source localization/neuroimaging approaches enable activity assessment in specific regions.…”

Section: Introductionmentioning

confidence: 99%

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Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females

Jaworska¹,

Blier²,

Fusee³

et al. 2012

Journal of Psychiatric Research

186

159

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Left fronto-cortical hypoactivity, thought to reflect reduced activity in approach-related systems, and right parietal hypoactivity, associated with emotional under-arousal, have been noted in major depressive disorder (MDD). Altered theta activity in the anterior cingulate cortex (ACC) has also been associated with the disorder. We assessed resting frontal and parietal alpha asymmetry and power in non-medicated MDD (N=53; 29 females) and control (N=43; 23 females) individuals. Theta activity was examined using standardized low-resolution electromagnetic tomography (sLORETA) in the ACC [BA24ab and BA32 comprising the rostral ACC and BA25/subgenual (sg) ACC]. The MDD group, and particularly depressed males, displayed increased overall frontal and parietal alpha power and left midfrontal hypoactivity (alpha2-indexed). They also exhibited increased sgACC theta2 activity. MDD females had increased right parietal activity, suggesting increased emotive arousal. Thus, unmedicated depressed adults were characterized by lower activity in regions implicated in approach/positive affective tendencies as well as diffuse cortical hypoarousal, though sex specific modulations emerged. Altered theta in the sgACC may reflect emotion regulation abnormalities in MDD.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females

Jaworska¹,

Blier²,

Fusee³

et al. 2012

Journal of Psychiatric Research

186

159

View full text Add to dashboard Cite

show abstract

“…Important state-of-the-art analysis tools based on mathematical approaches include: (1) phase synchrony in oscillations (Varela et al, 2001); and (2) methods of source localization (e.g., sLORETA (low-resolution brain electromagnetic tomography) which solves the “inverse problem” to generate anatomically constrained solutions of active sources within the brain that underlie the event-related scalp activity (Pascual-Marqui, 2002). The ERP and ERO analyses are supplemented by source localization techniques to infer anatomical substrates and have been successfully used to study several psychiatric disorders including AUDs (Coutin-Churchman and Moreno, 2008; Holmes and Pizzagalli, 2008; Kamarajan et al, 2010; Itoh et al, 2011; Pandey et al, 2012). Hence, these tools are instrumental in translating and comparing findings from electrophysiological studies with those from imaging methodologies, or using them in conjunction with each other, to create a multimodal approach.…”

Section: Event-related Oscillationsmentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.

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“…Electrophysiological techniques have further advantages of being non-invasive, relatively inexpensive to implement, and can be used to study a large variety of cognitive processes/brain functions; recently developed electrophysiological analytical techniques and methods allow for a better study of neural communication across different brain regions in normal [31-33] as well as pathological conditions [34-38], and provide subtle measures of neurocognitive (dys) function. More recent studies increasingly use localization techniques such as standardized low resolution brain electromagnetic tomography (sLORETA) to characterize specific activity patterns and communication across brain regions three-dimensionally and these methods have been implemented in many psychiatric disorders including alcoholism [9-11,39,40]. …”

Section: Introductionmentioning

confidence: 99%

Event-Related Oscillations in Alcoholism Research: A Review

Pandey

Kamarajan²,

Rangaswamy³

et al. 2012

J Addict Res Ther

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Alcohol dependence is characterized as a multi-factorial disorder caused by a complex interaction between genetic and environmental liabilities across development. A variety of neurocognitive deficits/dysfunctions involving impairments in different brain regions and/or neural circuitries have been associated with chronic alcoholism, as well as with a predisposition to develop alcoholism. Several neurobiological and neurobehavioral approaches and methods of analyses have been used to understand the nature of these neurocognitive impairments/deficits in alcoholism. In the present review, we have examined relatively novel methods of analyses of the brain signals that are collectively referred to as event-related oscillations (EROs) and show promise to further our understanding of human brain dynamics while performing various tasks. These new measures of dynamic brain processes have exquisite temporal resolution and allow the study of neural networks underlying responses to sensory and cognitive events, thus providing a closer link to the physiology underlying them. Here, we have reviewed EROs in the study of alcoholism, their usefulness in understanding dynamical brain functions/dysfunctions associated with alcoholism as well as their utility as effective endophenotypes to identify and understand genes associated with both brain oscillations and alcoholism.

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Intracranial current density (LORETA) differences in QEEG frequency bands between depressed and non-depressed alcoholic patients

Cited by 25 publications

References 55 publications

Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females

Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females

Understanding alcohol use disorders with neuroelectrophysiology

Event-Related Oscillations in Alcoholism Research: A Review

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