Intracranial chondrosarcoma with extracranial metastases

Waga, Shiro; Matsushima, Masayuki; Ando, Kyozo; Morii, Sotokichi

doi:10.3171/jns.1972.36.6.0790

Cited by 40 publications

(5 citation statements)

References 12 publications

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“…Table 3 summarizes 12 previous chondrosarcoma patients with BM and shows an average age of 43.4 years, with 6 males and 6 females (50%) [15, 39–48]. There were 2 children (age 18 and younger).…”

Section: Resultsmentioning

confidence: 99%

Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

Shweikeh

Bukavina

Saeed

et al. 2014

Sarcoma

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Bone and soft tissue malignancies account for a small portion of brain metastases. In this review, we characterize their incidence, treatments, and prognosis. Most of the data in the literature is based on case reports and small case series. Less than 5% of brain metastases are from bone and soft tissue sarcomas, occurring most commonly in Ewing's sarcoma, malignant fibrous tumors, and osteosarcoma. Mean interval from initial cancer diagnosis to brain metastasis is in the range of 20–30 months, with most being detected before 24 months (osteosarcoma, Ewing sarcoma, chordoma, angiosarcoma, and rhabdomyosarcoma), some at 24–36 months (malignant fibrous tumors, malignant peripheral nerve sheath tumors, and alveolar soft part sarcoma), and a few after 36 months (chondrosarcoma and liposarcoma). Overall mean survival ranges between 7 and 16 months, with the majority surviving < 12 months (Ewing's sarcoma, liposarcoma, malignant fibrous tumors, malignant peripheral nerve sheath tumors, angiosarcoma and chordomas). Management is heterogeneous involving surgery, radiosurgery, radiotherapy, and chemotherapy. While a survival advantage may exist for those given aggressive treatment involving surgical resection, such patients tended to have a favorable preoperative performance status and minimal systemic disease.

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Section: Resultsmentioning

confidence: 99%

Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

Shweikeh

Bukavina

Saeed

et al. 2014

Sarcoma

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“…A literature search revealed only two such previously reported cases. 2,3 To the best of our knowledge, this case represents the third one with such an occurrence. We have obtained a favorable outcome so far with a gross total excision of the lesion followed by postoperative radiotherapy.…”

Section: Introductionmentioning

confidence: 69%

Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case

Dutta

Singh

Saran

et al. 2018

J Neurol Surg A Cent Eur Neurosurg

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Chondrosarcoma is a rare malignant tumor originating from cartilaginous tissue with a tendency to localize in the epiphysis of long and pelvic bones. Only 7% of all chondrosarcomas originate in the craniocervical region. Metastasis from intracranial chondrosarcoma is extremely rare with only two previously reported cases. We report on a young patient with intracranial chondrosarcoma who presented with extracranial metastasis 2 years after surgical excision of the primary lesion. Gross total excision combined with radiotherapy so far has led to a favorable outcome.

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“… 14) Although the 5-year recurrence rate is high at 63%, 15) remote metastatic cases have been rarely reported. 8 , 16 , 17) …”

Section: Discussionmentioning

confidence: 99%

Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma

Murakami

Jinguji

Kishida

et al. 2018

NMC Case Report Journal

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We report a case of a young male who received multiple surgical treatments for repeated recurrence of skull base mesenchymal chondrosarcoma (MC). When the patient was 18 years old, we subtotally removed the skull base MC and he was treated with stereotactic radiosurgery for remnant tumors in the left cavernous sinus. After 30 months, we removed residual tumors that had regrown partially, via combined endonasal endoscopic and orbitozygomatic approaches. Over the next 65 months, the patient refused radical resection, and received six salvage surgeries, two stereotactic radiotherapies, and five stereotactic radiosurgeries for repeated recurrence. At 95 months after initial surgery, the tumors had extended to the skull base and nasal cavities. As a result, the left eye had been blinded and right visual acuity was deteriorated. We performed left anterior-middle cranial base resection, removal of nasal and intradural tumors, high flow bypass, en-bloc resection of the left cavernous sinus and clivus, and reconstruction using an abdominal flap. Even though the main tumors were removed with safety margins, tumors around the right optic nerve were removed by piecemeal to preserve right eye function. Six months after the radical resection, tumors in the right orbital apex recurred because we had been unable to remove the tumor with adequate safety margins. Skull base MC has a high tendency to recur locally, so these tumors should be radically removed with safety margins as early as possible to prevent recurrence.

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Intracranial chondrosarcoma with extracranial metastases

Abstract: ✓ This report describes a case of primary intracranial meningeal chondrosarcoma arising from the falx with extracranial metastases to the heart, liver, pancreas, kidneys, and adrenals.

Cited by 40 publications

References 12 publications

Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes

Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case

Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma

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