Intracranial Cell Lymphomas That Mimic Meningiomas: Case Report To Understand Complex Genetic, Radiologic, and Histopathologic Entities

Comes, P; André, Ana; Nguyen‐Khac, Florence; Carpentier, Alexandre; Bielle, Franck; Amelot, Aymeric

doi:10.1016/j.wneu.2019.01.298

Cited by 1 publication

(2 citation statements)

References 16 publications

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“…[ 4 - 6 , 13 , 29 , 32 ] T-cell PCNSL often presents as a single supratentorial lesion. [ 4 - 6 , 10 , 11 , 18 , 23 , 33 , 35 , 36 , 38 - 41 , 43 , 44 , 46 , 53 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 50 ] Historically, whole-brain radiation therapy (WBRT) was the treatment of choice, as these lesions are very sensitive to radiotherapy. [ 10 , 14 ] However, this method causes a risk of severe neurotoxicity and is no longer the standard of care. [ 14 ] Recently, hippocampal sparing WBRT has been proposed and evaluated as a radiation method that limits the neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

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Primary peripheral T-cell central nervous system lymphoma

Bird

Traylor

Thomas

et al. 2021

Surgical Neurology International

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Background: Primary peripheral T-cell central nervous system lymphoma (PCNSL) is a rare, aggressive tumor that arises in the craniospinal axis and has an increased risk in individuals who are immunocompromised. This lesion often mimics other benign and malignant processes on radiographic imaging, leading to misdiagnosis and delays in treatment. We present a case of a patient with a history of Sjögren’s syndrome and progressive neurologic symptoms who underwent craniotomy for diagnosis. Case Description: A 61-year-old woman with a history of Sjögren’s syndrome, progressive aphasia, left facial droop, and right-sided paresthesias for 4 months presented for evaluation and management. An enhancing, infiltrative lesion in the left frontal lobe with underlying vasogenic edema was appreciated and suggestive of a primary or metastatic neoplasm. The patient underwent an open biopsy for further evaluation of the lesion. Extensive histopathologic evaluation revealed a diagnosis of T-cell PCNSL. The patient was started on induction methotrexate and temozolomide followed by consolidative radiotherapy. Conclusion: Autoimmune conditions are a risk factor for T-cell PCNSL development. T-cell PCNSL has radiographic and gross histologic features that are consistent with a broad differential, including gliomas and inflammatory processes. Prompt diagnosis and extensive histopathological evaluation is essential to ensure appropriate treatment.

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“…[ 4 - 6 , 13 , 29 , 32 ] T-cell PCNSL often presents as a single supratentorial lesion. [ 4 - 6 , 10 , 11 , 18 , 23 , 33 , 35 , 36 , 38 - 41 , 43 , 44 , 46 , 53 ]…”

Section: Discussionmentioning

confidence: 99%