Intracranial Aneurysms and Heredity

Norrgård, Örjan; Ängquist, Karl‐Axel; Fodstad, Harald; Forsell, A; Lindberg, Maria

doi:10.1227/00006123-198702000-00006

Cited by 123 publications

(34 citation statements)

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“…10 - 13 One recent study concluded that 7% of all intracranial aneurysms may be familial. 11 The familial occurrence of spontaneous extracranial carotid artery dissection has been described in two families seen in our institution. 14 Ehlers-Danlos syndrome type IV and Marfan's syndrome are heritable connective tissue diseases associated with intracranial aneurysms as well as cervical artery dissection.…”

Section: Discussionmentioning

confidence: 92%

Familial association of intracranial aneurysms and cervical artery dissections.

Schievink

Mokri

Michels

et al. 1991

Stroke

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Background and Purpose:The familial occurrence of intracranial aneurysms and cervical artery dissections has been described in different families and supports the hypothesis that a primary arteriopathy may play a role in the pathogenesis of these disorders. Although the basis for this arteriopathy is generally not believed to be similar among cases of intracranial aneurysms and cervical artery dissections, several similarities exist in the epidemiology of these disorders and a common underlying arterial abnormality may be suspected. Summary of Reports:The medical records of all 175 patients with spontaneous dissections of the cervical arteries who were seen at the Mayo Clinic between 1970 and 1989 were reviewed to identify families in which intracranial aneurysms and cervical dissections coexisted. Three families were identified in which intracranial aneurysms and cervical artery dissections were observed among siblings. These families are described in detail.Conclusions: The familial occurrence of intracranial aneurysms and cervical artery dissections within the same families provides support to the importance of a common underlying arteriopathy in the pathogenesis of both these disorders. The underlying vascular defect may, at least in some cases, be inherited. (Stroke 1991;22:1426-1430)

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Section: Discussionmentioning

confidence: 92%

Familial association of intracranial aneurysms and cervical artery dissections.

Schievink

Mokri

Michels

et al. 1991

Stroke

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“…Thus, a 2-to 6-fold increased risk of SAH has been reported among first-degree relatives of SAH index patients. [5][6][7][8][9][10] The largest documented pedigree included 6 clinically manifest individuals and displayed an apparently autosomal dominant inheritance. 11 The underlying molecular defect is thought to affect connective tissue development, given than IA has been reported to be part of the phenotype in several human inherited connective tissue abnormalities.…”

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confidence: 99%

Elastin Polymorphism Haplotype and Intracranial Aneurysms Are Not Associated in Central Europe

Höfer

Hermans²,

Kubassek³

et al. 2003

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“…In a series of 485 SAH patients, Norrgard et al 2 identified by means of a questionnaire survey 32 patients (6.6%) with a first-to third-degree relative who had a SAH. The number of relatives at risk and the method of confirming the diagnosis in these relatives were not reported.…”

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confidence: 99%

“…1210 However, multiplicity varies considerably from family to family; in one retrospective study it was as high as 53%. 2 Even familial IAs seldom occur under the age of 20 years. 11 So far, only seven such patients have been reported, the youngest being 4 years old, 511 -15 which must be taken into account in decisions about elective screening.…”

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confidence: 99%