Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population

Abstract

ABSTRACT. Few studies have examined the genes related to risk factors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression models were used to analyze the association of IA and IA rupture with risk factors. Twenty-eight single nucleotide polymorphisms (SNPs) in 22 genes were genotyped for the patient and control groups. SNP genotypes and allele frequencies were analyzed by the chi-square test. Logistic regression analysis identified hypertension as a factor that increased IA risk (P = 1.0 x 10 -4 ; OR, 2.500; 95%CI, 1.573-3.972); IA was associated with two SNPs in the TSLC2A9 gene: rs7660895 (P = 0.007; OR, 1.541; 95%CI, 1.126-2.110); and in the TOX gene: rs11777927 (P = 0.013; OR, 1.511; 95%CI, 1.088-2.098). Subsequent removal of the influence of family relationship identified between 12 of 119 patients enhanced the significant association of these SNPs with IA (P = 0.001; OR, 1.691; 95%CI, 1.226-2.332; and P = 0.006; OR, 1.587; 95%CI, 1.137-2.213 for rs7660895 and rs11777927, respectively). Furthermore, the minor allele of rs7660895 (A) was also associated with IA rupture (P = 0.007; OR, 2.196; 95%CI,. Therefore, hypertension is an independent risk factor for IA. Importantly, the TSL-C2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of IAs, and rs7660895 may be associated with IA rupture.

Treatment of Unruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: Primum Non Nocere

“…There is effort to improve the assessment of risk for IA progression and rupture with clinical and radiographic features 12 and a molecular biology approach. 13,14 However, these new risk factors have to be tested in the ADPKD population to verify their utility in this particular group.…”

Uncovering of Key Pathways and miRNAs for Intracranial Aneurysm Based on Weighted Gene Co-Expression Network Analysis

“…Moreover, the regulation of MYOCD on the progression of IA is targeted by miR-9 [50]. Thymocyte selection associated high mobility group box (TOX) gene polymorphisms may be associated with the formation of IA [51]. In the present study, MYOCD and TOX were the target genes for hsa-miR-6875-3p.…”

TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese

“…To the best of our knowledge, only one association study of rs11777927 and disease—intracranial aneurysm— has been reported33. The biological connections between TOX and AIWG are poorly understood, perhaps owing to the inflammatory responses mediated by immune cells, developmentally regulated by TOX gene, contributing to AIWG.…”