Intracranial Aneurysm Pathophysiology: To Bleed, or not To Bleed, That Is the Question

Broggi, Morgan; Acerbi, Francesco

doi:10.1016/j.wneu.2015.08.001

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Studies reported that ruptured aneurysms were usually irregular in shape. The convex part of the aneurysm surface is thinner and prone to rupture (8)(9)(10). Previously, researchers have tried to describe the morphology of aneurysms and the degree of irregularity in various ways, finding the relationship between each measured parameter and the risk of aneurysm rupture.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the wall thickness of intracranial aneurysms: Can computational fluid dynamics detect the translucent areas of saccular intracranial aneurysms and predict the rupture risk preoperatively?

Fan

Geng²,

He³

et al. 2023

Front. Neurol.

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Background and purposeThe translucent area on the surface of intracranial aneurysms (IAs) is associated with rupture risk. In the present study, the Polyflow module of the Ansys software was used to simulate and analyze the thickness of the aneurysm wall to detect whether it was “translucent” and to assess the rupture risk.MethodsForty-five patients with 48 IAs who underwent microsurgery were retrospectively reviewed. The medical records, radiographic data, and intraoperative images of the patients were collected. The image data were analyzed using computational fluid dynamics (CFD) simulations to explore the relationship between the simulated thickness of the aneurysm wall, the translucent area, and the rupture point of the real aneurysm's surface to predict the rupture risk and provide a certain reference basis for clinical treatment.ResultsThe Polyflow simulation revealed that the location of the minimum extreme point of the simulated aneurysm wall thickness was consistent with the translucent area or rupture point on the surface of the real aneurysm. There was a downward trend in the correlation between the change rate (IS) in the wall area and volume during aneurysm growth and rupture. Ruptured aneurysms have a greater inhomogeneity coefficient Iδ than the unruptured ones. In the unruptured group, translucent aneurysms also had greater inhomogeneity coefficients Iδ and more significant thickness changes (multiple IBA) than non-translucent ones.ConclusionsThe Ansys software Polyflow module could detect whether the unruptured aneurysms were translucent and predict the rupture risk and rupture point.Clinical trial registrationhttps://clinicaltrials.gov/, Identifier, NCT03133624.

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Section: Discussionmentioning

confidence: 99%