Intracranial and Spinal Melanotic Schwannoma in the Same Patient

Buhl, Ralf; Barth, Harald; Hugo, Heinz-Hermann; Mautner, Victor; Mehdorn, H. M.

doi:10.1023/b:neon.0000033491.23654.6c

Cited by 26 publications

(27 citation statements)

References 12 publications

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“…[24] These tumors most frequently occur in the cervical and thoracic spine (46%). [521] Spinal melanotic schwannomas are usually benign,[1671012131718202627] but two cases of psammomatous spinal melanotic schwannomas have been reported. [1117]…”

Section: Discussionmentioning

confidence: 99%

Malignant psammomatous melanotic schwannoma of the spine: A component of Carney complex

Shields¹,

Glassman²,

Raque³

et al. 2011

Surg Neurol Int

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Background:Psammomatous melanotic schwannomas (PMS) of the spine may be a component of the Carney complex in 50% of cases and is inherited in an autosomal dominant manner. Most PMS are benign and frequently associated with lentiginous pigmentation; cardiac, cutaneous, or breast myxomas; endocrine overactivity; and cutaneous blue nevi. These tumors are characterized by melanin containing cells having ultrastructural characteristics of Schwann cells.Case Description:Two patients had spinal PMS that were surgically resected with adjacent local radiotherapy, followed by local recurrence and metastasis. The aggressive nature of this tumor is reported.Conclusion:Spinal PMS are rarely malignant with local recurrence and distal metastases. Inquiry into the patient's and family members’ hereditary background for the Carney complex is important to avoid overlooking potential lethal associated abnormalities.

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Section: Discussionmentioning

confidence: 99%

Malignant psammomatous melanotic schwannoma of the spine: A component of Carney complex

Shields¹,

Glassman²,

Raque³

et al. 2011

Surg Neurol Int

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“…Patients usually present with symptoms of nerve compression (63). These lesions are more typically intracranial, but they also occur within the spinal canal (69). When they develop within the spine, the tumors most often arise in the thoracic region and they may be intramedullary (70).…”

Section: Imaging Appearancementioning

confidence: 99%

“…Metastasis and meningeal seeding have been reported but are exceedingly rare (Fig 12) (64). Treatment consists of surgical resection, and the prognosis is typically excellent if complete resection is achieved (69). In a review by Killen et al (71), 24% of all melanotic schwannomas were noted to recur, and patients with tumors associated with the cranial nerves had the worst prognosis.…”

Section: Imaging Appearancementioning

confidence: 99%

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Smith¹,

Rushing²,

2009

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Pigmented lesions of the central nervous system (CNS) are a diverse group of entities that run the gamut from benign to malignant. These lesions may be well circumscribed or diffuse, and their imaging appearances are influenced by the degree of melanin content as well as the presence or absence of hemorrhage. Pigmented lesions include primary melanocytic lesions of the CNS and metastatic melanoma, as well as other CNS neoplasms that may undergo melanization, including schwannoma, medulloblastoma, and some gliomas. Primary melanocytic lesions of the CNS arise from melanocytes located within the leptomeninges, and this group includes diffuse melanocytosis and meningeal melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and malignant melanoma. Primary melanin-containing lesions of the CNS must be differentiated from metastatic melanoma because these lesions require different patient workup and therapy. Absence of a known primary malignant melanoma helps in the differential diagnosis, but an occult primary lesion outside the CNS must be sought and excluded. Pigmented lesions of the CNS are uncommon, and knowledge of their imaging characteristics and pathologic features is essential for their identification.

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“…4 Various other cystic lesions can occur in the spinal canal, such as arachnoid cysts, epidermoids/dermoids, terminal meningomyelocele, and dural ectasia. 3C), 6 or rapid tumor growth 4,5 and malignant transformation. Internal septations, irregularity, and nodular thickening of walls on contrast-enhanced images (Fig.…”

Section: Schwannoma With Cystic Changesmentioning

confidence: 99%

“…Tarlov cysts (root sleeve cysts), intrasacral cysts, facet joint synovial/ ganglion cysts, cysticercosis, and hydatid cysts are other cystic lesions in the spine that need to be considered. 6 MELANOTIC/MELANOCYTIC SCHWANNOMA Melanotic schwannomas are characterized by cytoplasmic deposition of melanin pigment. 2C), difference in the thickness of walls, hyperintensity of contents compared with the adjacent cerebrospinal fluid, and fluid-fluid levels are some features suggestive of cystic spinal schwannoma.…”

Section: Schwannoma With Cystic Changesmentioning

confidence: 99%

Pictorial Essay

Parmar¹,

Ibrahim²,

Castillo³

et al. 2007

Journal of Computer Assisted Tomography

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In this pictorial review, we present diverse imaging features of spinal schwannomas with an idea to familiarize spine imagers with the varied spectrum of presentation of these tumors. Different types of spinal schwannomas presented include multiple schwannoma (n = 3), schwannoma with cystic degeneration (n = 3), schwannoma with hemorrhage (n = 2), melanotic schwannoma (n = 1), intraosseous schwannoma (n = 2), schwannoma growing into the foramen transversarium (n = 1), intramedullary schwannoma (n = 1), large or giant schwannoma (n = 1), malignant schwannoma (n = 2), and infarcted schwannoma (n = 1). We present imaging findings in these cases and review their differential diagnosis. Awareness of the uncommon presentations of these seemingly common tumors is important in offering a correct diagnosis.

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Intracranial and Spinal Melanotic Schwannoma in the Same Patient

Cited by 26 publications

References 12 publications

Malignant psammomatous melanotic schwannoma of the spine: A component of Carney complex

Malignant psammomatous melanotic schwannoma of the spine: A component of Carney complex

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Pictorial Essay

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