Intracortical Circuits in Thalamorecipient Layers of Auditory Cortex Refine after Visual Deprivation

Meng, Xiangying; Kao, Joseph P. Y.; Lee, Hey Kyoung

doi:10.1523/eneuro.0092-17.2017

Cited by 31 publications

(48 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study demonstrated that 1 week of visual deprivation strengthens thalamo‐cortical synapses in A1 in juvenile and adult mice (Petrus et al ., ). This effect was shown to be accompanied by an increased sensitivity and frequency tuning of A1 neurons (Petrus et al ., ) and refined intracortical circuits in the spared A1 (Meng et al ., ). Likewise, visual deprivation sharpened the functional whisker‐barrel map at layer 2/3 in the barrel cortex.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Cross‐modal refinement of visual performance after brief somatosensory deprivation in adult mice

Teichert¹,

Isstas²,

Wenig³

et al. 2018

Eur J of Neuroscience

View full text Add to dashboard Cite

It is well established that the congenital lack of one sensory modality enhances functionality in the spared senses. However, whether a late onset deprivation of one sense leads to such alterations is largely unknown. Here, we investigated whether a somatosensory deprivation induced by bilateral whisker removal affects visual acuity and contrast sensitivity in fully adult mice. Using the visual cortex-dependent visual water task, we found that a brief somatosensory deprivation markedly improved behavioral visual acuity and contrast sensitivity by about 40%. Determining these attributes of vision using periodic optical imaging of intrinsic signals in the same mice revealed that visual cortex responses elicited by weak visual stimuli were massively increased after somatosensory deprivation. Strikingly, comparison of visual acuity and contrast sensitivity values determined by the visual water task and intrinsic signal imaging revealed that these measurements were almost identical, even at the level of individual animals. In summary, our results suggest that a brief manipulation of somatosensory experience profoundly boosts visual cortex-dependent vision in adults.

show abstract

Section: Discussionmentioning

confidence: 97%

“…In this regard, it was demonstrated that 1 week of dark exposure (DE) leads to an improved frequency selectivity and discrimination performance of neurons in the auditory cortex (A1; Petrus et al ., ). In addition, the same treatment refined intra‐ and inter‐laminar connections in A1 (Meng et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Cross‐modal refinement of visual performance after brief somatosensory deprivation in adult mice

Teichert¹,

Isstas²,

Wenig³

et al. 2018

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Consistent with the notion that these differences might reflect differences in neural tuning within individual neurons, Petrus et al (2014) have shown that adult-onset visual deprivation over 6 -8 d sharpens the frequency tuning of individual neurons within A1 in the mouse. Moreover, the same brief period of visual deprivation leads to more refined interlaminar connections (Meng et al, 2015(Meng et al, , 2017, highlighting the capability for rapid remodeling of auditory frequency representations, even after the closure of the canonical critical period.…”

Section: Tuning Widthmentioning

confidence: 99%

Early Blindness Shapes Cortical Representations of Auditory Frequency within Auditory Cortex

et al. 2019

View full text Add to dashboard Cite

Early loss of vision is classically linked to large-scale cross-modal plasticity within occipital cortex. Much less is known about the effects of early blindness on auditory cortex. Here, we examine the effects of early blindness on the cortical representation of auditory frequency within human primary and secondary auditory areas using fMRI. We observe that 4 individuals with early blindness (2 females), and a group of 5 individuals with anophthalmia (1 female), a condition in which both eyes fail to develop, have lower response amplitudes and narrower voxelwise tuning bandwidths compared with a group of typically sighted individuals. These results provide some of the first evidence in human participants for compensatory plasticity within nondeprived sensory areas as a result of sensory loss.

show abstract

“…For instance, one week of visual deprivation strengthens thalamocortical synapses in A1 (Petrus et al., ). This effect was shown to be accompanied by a refinement of intracortical circuits in A1 (Meng, Kao, Lee, & Kanold, ) and an increased sensitivity and frequency tuning of A1 neurons (Petrus et al., ). Furthermore, we could recently demonstrate that 7–12 days of whisker deprivation (WD) profoundly refines visual performance and V1 spatial frequency and contrast tuning in fully adult mice (Teichert, Isstas et al., ).…”

Section: Introductionmentioning

confidence: 99%

Cross‐modal restoration of ocular dominance plasticity in adult mice

Teichert¹,

Isstas²,

Zhang³

et al. 2018

Eur J of Neuroscience

View full text Add to dashboard Cite

The temporal closure of one eye in juvenile and young adult mice induces a shift of the ocular dominance (OD) of neurons in the binocular visual cortex. However, OD plasticity typically declines with age and is completely absent in matured mice beyond postnatal day (PD) 110. As it has been shown that the deprivation of one sensory input can induce neuronal alterations in non-deprived sensory cortices, we here investigated whether cross-modal interactions have the potential to reinstall OD plasticity in matured mice. Strikingly, using intrinsic signal imaging we could demonstrate that both whisker deprivation and auditory deprivation for only one week reinstated OD plasticity in fully adult mice. These OD shifts were always mediated by an increase of V1 responsiveness to visual stimulation of the open eye, a characteristic feature of OD plasticity normally only found in young adult mice. Moreover, systemic administration of the competitive NMDA receptor antagonist CPP completely abolished cross-modally induced OD plasticity. Taken together, we demonstrate here for the first time that the deprivation of non-visual senses has the potential to rejuvenate the adult visual cortex.

show abstract

Intracortical Circuits in Thalamorecipient Layers of Auditory Cortex Refine after Visual Deprivation

Abstract: Visual Abstract

Cited by 31 publications

References 39 publications

Cross‐modal refinement of visual performance after brief somatosensory deprivation in adult mice

Cross‐modal refinement of visual performance after brief somatosensory deprivation in adult mice

Early Blindness Shapes Cortical Representations of Auditory Frequency within Auditory Cortex

Cross‐modal restoration of ocular dominance plasticity in adult mice

Contact Info

Product

Resources

About