Abstract. End-stage renal disease (ESRD) patients treated with hemodialysis have a high mortality rate, which is largely due to inadequate dialysis. Dialysis adequacy, measured by the urea reduction ratio (URR), tends to be correlated within dialysis facilities with wide variations in average center adequacy. These are characteristics of a center effect, which can have an important impact on dialysis adequacy. This study measured the center effect observed in an ESRD Network before and after a successful quality improvement project (QIP). URR values were recorded on patients sampled from 196 facilities in ESRD Network 6 before (pre-QIP, n Ļ 5309) and after (post-QIP, n Ļ 5753). These data was used to determine the within center correlation () of individual URR values and between center variation in aggregate URR values in both samples. The overall mean URR improved from the pre-to post-QIP sample (mean URR 64.7 Ļ® 0.1 versus 69.8 Ļ® 0.1, respectively; P Ļ 0.001). There was a high degree of within center correlation in dialysis adequacy across the facilities, which significantly diminished post-QIP (, 0.15 [95% CI, 0.12 to 0.18] versus , 0.06 [95% CI, 0.04 to 0.08]). The between center variation in mean URR also declined from the pre-QIP to the post-QIP sample (SD, 3.6 versus 2.8). In conclusion, there is a center effect on dialysis adequacy measurable in an ESRD Network, which diminishes after a successful QIP; therefore, when implementing a QIP to improve dialysis adequacy, changes in the center effect should be considered a potential indicator of the efficacy of the intervention.The health and well being of patients with end-stage renal disease (ESRD) continues to be dismal (1), and much of this poor outcome can be attributed to inadequate treatment with hemodialysis, which is the renal replacement therapy for a majority of patients with this disease (2-6). Although there are national standards for adequate dialysis (7), there are several barriers to achieving these mandated treatment goals. Efforts to improve dialysis adequacy have emphasized correcting patientspecific factors that are linked to inadequate dialysis (8 -11). It is likely that factors at the center level also contribute to the shortcomings in dialysis treatment.When present, such center effects on dialysis adequacy results in patients from the same dialysis unit receiving similar doses of dialysis compared with patients from different centers. A high degree of intrafacility or within center correlation in dialysis adequacy would suggest not only that patients are influenced by a center effect but also that the patients with poor care were not randomly distributed among dialysis facilities. A related finding to an observed center effect in a population of dialysis patients is that aggregate achieved adequacy in centers is widely variant. The between center variation in performance results in some centers having overall adequacy exceeding mandated goals while others underperform, which is also consistent with the possibility that poorly dialyzed pa...