Intracerebroventricular insulin enhances memory in a passive-avoidance task

Park, Collin R.; Seeley, Randy J.; Craft, Suzanne; Woods, Stephen C.

doi:10.1016/s0031-9384(99)00220-6

Cited by 305 publications

(193 citation statements)

References 49 publications

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“…This result robustly replicates the beneficial effect of intranasal insulin on declarative memory seen in normal-weight men and women 8,9 as well as findings in animals where intracerebroventricular administration of the compound enhanced memory functions. 5,27 Declarative memory comprises the acquisition and recall of facts and events. Its formation relies primarily on Brain insulin signaling in obesity M Hallschmid et al hippocampal structures and adjacent cortices 18 where brain insulin receptors are predominantly found.…”

Section: Discussionmentioning

confidence: 99%

“…2 Administration of insulin to the central nervous system (CNS) reduces food intake and body weight. 3,4 Moreover, insulin administration enhances memory functions in rats 5 and humans, [6][7][8][9] indicating that CNS insulin signaling is also involved in cognitive functioning. Circulating insulin accesses the CNS primarily via a saturable, active transport across the blood-brain barrier.…”

Section: Introductionmentioning

confidence: 99%

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Obese men respond to cognitive but not to catabolic brain insulin signaling

et al. 2007

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Context and objective: Insulin acts in the brain to reduce food intake and body weight and is considered a major adiposity signal in energy homeostasis. In normal-weight men, intranasal insulin administration reduces body fat and improves declarative memory. The present experiments aimed to generalize these findings to obese patients, with a view to evaluate the therapeutic potential of the compound. Design, subjects and measurements: Insulin and placebo, respectively, were intranasally administered four times a day (amounting to 160 IU day À1 ) over 8 weeks to two groups of 15 obese men each. Results: Contrasting with the catabolic effects in normal-weight men, insulin treatment did not induce any significant reduction of body weight (P40.50) and body fat (P40.44) in the obese subjects. However, in accordance with the effects in normalweight men, declarative memory and mood were improved (Po0.05) and hypothalamic-pituitary-adrenal axis activity as assessed by circulating ACTH (Po0.01) and cortisol levels (Po0.04) was reduced. Conclusions: Our results indicate that in obese men, intranasal insulin is functionally active in the central nervous system but fails to affect the neuronal networks critically involved in body weight regulation. We conclude that obesity in men is associated with central nervous resistance to the adiposity signal insulin. This defect likely contributes to the persistence of obesity in spite of elevated levels of circulating insulin in obese patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obese men respond to cognitive but not to catabolic brain insulin signaling

et al. 2007

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“…Previous studies have also revealed that obesity-dependent deficits in cognition predominantly involved executive functions [35,36]. It has been shown that insulin increases memory, probably by binding to receptors in the hippocampus and the limbic part of the brain [37], while other studies show that insulin administration improves memory functions in non-obese patients [38,39]. However, in obese patients, insulin sensitivity is reduced and the resulting impairment in vocabulary memory can lead to verbal disabilities.…”

Section: Discussionmentioning

confidence: 99%

Relation of insulin resistance to neurocognitive function and electroencephalography in obese children

Akın

Eker

Arslan

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Childhood obesity may lead to neuronal impairment in both the peripheral and the central nervous system. This study aimed to investigate the impact of obesity and insulin resistance (IR) on the central nervous system and neurocognitive functions in children. Methods: Seventy-three obese children (38 male and 35 female) and 42 healthy children (21 male and 21 female) were recruited. Standard biochemical indices and IR were evaluated. The Wechsler Intelligence Scale for Children-Revised (WISC-R) and electroencephalography (EEG) were administered to all participants. The obese participants were divided into two groups based on the presence or absence of IR, and the data were compared between the subgroups. Results: Only verbal scores on the WISC-R in the IR+ group were significantly lower than those of the control and IRgroups. There were no differences between the groups with respect to other parameters of the WISC-R or the EEG. Verbal scores of the WISC-R were negatively correlated with obesity duration and homeostatic model assessmentinsulin resistance (HOMA-IR) values. EEGs showed significantly more frequent 'slowing during hyperventilation' (SDHs) in obese children than non-obese children.

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“…Peptide aggregation was performed as previously described (44); briefly, Aβ [25][26][27][28][29][30][31][32][33][34][35] peptides (Sigma-Aldrich, USA) were dissolved in phosphate-buffered saline at a concentration of 2 mg/ml and incubated for peptide aging or aggregation at 37°C for 4 days.…”

Section: Aβ Preparation and Agingmentioning

confidence: 99%

Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer’s disease

Farzampour¹,

Majdi²,

Sadigh-Eteghad³

2016

Physiology International

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Recently, insulin has been used as a pro-cognitive agent for the potential treatment of Alzheimer's disease (AD), because of its ability to cross the brain-blood barrier (BBB) by a saturable transport system. This study has been designed to evaluate the effects of intranasal insulin regimen, as a bypass system of BBB, on spatial memory in amyloid-beta (Aβ) model of AD in rat. Unilateral infusion of Aβ 25-35 (10 nmol/2 μl/rat) into the lateral ventricular region of brain was used to produce a rat model of AD. After a 24-h recovery period, rats received insulin or vehicle via intraperitoneal or intranasal route (0.1, 0.2, and 0.3 IU) for 14 days. Memory function in rats was assessed by Morris water maze test, with 5 days of training and consequent probe test protocol. Different doses of intraperitoneal insulin did not have a significant effect on learning and memory in AD rats. However, intranasal insulin at doses of 0.2 and 0.3 IU improved the learning and memory in Aβ-received rats.In conclusion, intranasal insulin as a non-invasive strategy improves spatial learning and memory in AD model.

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Intracerebroventricular insulin enhances memory in a passive-avoidance task

Cited by 305 publications

References 49 publications

Obese men respond to cognitive but not to catabolic brain insulin signaling

Obese men respond to cognitive but not to catabolic brain insulin signaling

Relation of insulin resistance to neurocognitive function and electroencephalography in obese children

Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer’s disease

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