Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice

Qin, Yu; Shang, Lei; Liao, Zhengzheng; Su, Hang; Jing, Huiting; Wu, Bo; Bi, Kaishun; Jia, Ying

doi:10.1007/s11011-018-0348-6

Cited by 60 publications

(28 citation statements)

References 35 publications

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“…One study has reported that resveratrol provides a beneficial effect on AD rats by downregulation of NF- κ B p65, A β , and MMP-9 [ 105 ]. Another study has shown that resveratrol ameliorated the A β -induced cognitive deficits in AD mice by upregulation of SIRT1 and downregulation of NF- κ B/IL-1 β /NLRP3 [ 157 ]. However, numerous evidences indicated the beneficial effects of SIRT1 in AD by regulating the expression of A β and tau protein.…”

Section: Sirt1 and Cns Diseasesmentioning

confidence: 99%

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Jiao

Gong

2020

Oxidative Medicine and Cellular Longevity

160

106

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Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, metabolism, cancer, and stress. Neuroinflammation is associated with many neurological diseases, including ischemic stroke, bacterial infections, traumatic brain injury, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Recently, numerous studies indicate the protective effects of SIRT1 in neuroinflammation-related diseases. Here, we review the latest progress regarding the anti-inflammatory and neuroprotective effects of SIRT1. First, we introduce the structure, catalytic mechanism, and functions of SIRT1. Next, we discuss the molecular mechanisms of SIRT1 in the regulation of neuroinflammation. Finally, we analyze the mechanisms and effects of SIRT1 in several common neuroinflammation-associated diseases, such as cerebral ischemia, traumatic brain injury, spinal cord injury, AD, and PD. Taken together, this information implies that SIRT1 may serve as a promising therapeutic target for the treatment of neuroinflammation-associated disorders.

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Section: Sirt1 and Cns Diseasesmentioning

confidence: 99%

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Jiao

Gong

2020

Oxidative Medicine and Cellular Longevity

160

106

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“…They can be classified according to the number of phenol rings presented and the structural components that bind these rings in phenolic acids (hydroxycinnamic and hydroxybenzoic acids), flavonoids (benzene rings) and less common stilbene and lignans, although other categorizations exist (5). Previous research has demonstrated that different purified polyphenols such as resveratrol, curcumin, anthocyanin, ferulic acid, catechin and epicatechin were able to prevent cognitive decline in experimental animal models of aging and degenerative diseases (6)(7)(8)(9)(10). A plethora of observational and intervention studies observed a positive correlation between cognitive decline and the supplementation of different products rich in polyphenols like cocoa, berries, green tea and grape (11)(12)(13)(14)(15)).…”

Section: Polyphenolsmentioning

confidence: 99%

The role of diet in preventing and reducing cognitive decline

Angeloni

Businaro

Vauzour

2020

Current Opinion in Psychiatry

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Purpose of Review This review summarizes the most recent evidence regarding the effects of diet in preventing and reducing age-related cognitive decline and neurodegenerative diseases. Recent Findings Recent evidence indicates that nutraceuticals and whole diet approaches may protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects are diverse depending on the nutrient employed and may involve a reduction of neuroinflammation, an activation of the endogenous antioxidant defence system and a modulation of the gut microbiota structure and function.

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“…In the primary cortical neurons, resveratrol exerted neuroprotective effects against oxyhemoglobin insults including reduced neuronal apoptosis and degeneration, which also supported the in vivo findings. Recently, the neuroprotective effect of resveratrol through regulation of the NLRP3 inflammasome has also been reported in an animal model of AD with intracerebroventricular injection of Aβ . Resveratrol not only alleviated learning and memory impairments but also increased expression of Sirt1, AMPK, and PKC‐1α in the hippocampus and prefrontal cortex of Aβ‐injected mice.…”

Section: Health Promoting Potentials Of Dietary Phytochemicalsmentioning

confidence: 87%

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

Hung

Pan

2019

Molecular Nutrition Food Res

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Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase‐1‐mediated interleukin‐1β and interleukin‐18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome‐mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant‐derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders.

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Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice

Cited by 60 publications

References 35 publications

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

The role of diet in preventing and reducing cognitive decline

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

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