Intracerebroventricular injection of orexin-A, but not orexin-B, induces arousal of layer-type neonatal chicks

Katayama, Shigenori; Hamasu, Kousuke; Shigemi, Kazutaka; Cline, Mark A.; Furuse, Mitsuhiro

doi:10.1016/j.cbpa.2010.05.018

Cited by 23 publications

(21 citation statements)

References 24 publications

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“…Food intake was not affected by any treatment in the present study (saline, 2.376 ± 0.696; orexin-A, 1.189 ± 0.256; clorgyline, 0.770 ± 0.191; orexin-A + clorgyline, 1.213 ± 0.432), which supports previous reports in which orexin-A did not alter food intake in chicks [5,8].…”

supporting

confidence: 80%

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Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks

Katayama

Shigemi

Cline

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. We previously demonstrated that intracerebroventricular (ICV) injection of orexin-A induces arousal and increased metabolic turnover rates of norepinephrine, dopamine, and serotonin in layer (egg-type) chicks. Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAO-A. Therefore, we simultaneously injected clorgyline, a specific inhibitor of MAO-A, with orexin-A and examined behavior of chicks. Behaviors associated with arousal were attenuated in the group of chicks that received clorgyline and orexin-A compared with those that received orexin-A alone. For the monoamine turnover rate, enhancement of the turnover rate of serotonin by orexin-A was attenuated by clorgyline. Therefore, we conclude that orexin-A-induced arousal is dependent upon monoamine neural activities stimulated by MAO-A in chicks.

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confidence: 80%

“…Recently, we reported that orexin-A increased arousal in layer, but not broiler, chicks and that orexin-B is not likely to be involved in chick sleep/wake cycles [8]. Possible mechanisms associated with these behavioral affects may involve the hypothalamic-pituitary-adrenal (HPA) axis and/ or activation of monoamine neurons.…”

mentioning

confidence: 99%

Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks

Katayama

Shigemi

Cline

et al. 2011

The Journal of Veterinary Medical Science

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“…Interestingly, orexin-A had no effect on arousal in broiler chicks however they spent less time feeding. Additionally, orexin-B had no effect on arousal and food intake neither in layer nor broiler [71] . As seen, orexin has different effects in domestic birds.…”

Section: Orexinmentioning

confidence: 78%

“…The differential responses to orexins in the two strains can related to variances in their receptors. Orexin-A is a ligand of both OX 1 R and OX 2 R whereas orexin-B activates only OX 2 R. Also, OX 1 R is associated with the Gq subclass of G proteins while OX 2 R is likely associated with the Gq and Gi/o [71] . In conclusion, presumably orexins induce feeding behavior acts via different neurological pathways in mammals and birds.…”

Section: Orexinmentioning

confidence: 99%

Central regulation of food intake in mammals and birds: a review

Zendehdel

Hassanpour

2015

Neurotransmitter

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Appetite regulates by a complex system of central and peripheral signals which interact in order to modulate ingestion response. A number of peptides comprise a complex network that regulates feeding behavior in vertebrates. This review is focused on the main neurotransmitters and peptides that influence feeding responses in mammals and birds. On the basis of literature review, there are several evidences that neurotransmitters have different effects on food intake between mammals and birds. Also, central regulation of food intake regulates via different mechanisms in animals. So, the aim of this review was to investigate comparative food-intake regulation mechanisms in mammals and birds.

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“…Both orexin and its receptor were expressed in chicken brain and gonads (testis and ovary) (49). Central administration of orexin did not affect feed intake in neonatal chickens (24), and its effects on sleep/wakefulness cycle is still controversial (33,34,45). The localization of orexin and its receptors in chicken peripheral tissues, such as testis, ovary, stomach, and intestine (3, 49), indicates that orexin system may have other physiological functions rather than the regulation of feeding behavior.…”

mentioning

confidence: 98%

Orexin system is expressed in avian muscle cells and regulates mitochondrial dynamics

Lassiter¹,

Greene²,

Piekarski³

et al. 2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Orexin A and B, orexigenic peptides produced primarily by the lateral hypothalamus that signal through two G protein-coupled receptors, orexin receptors 1/2, have been implicated in the regulation of several physiological processes in mammals. In avian (nonmammalian vertebrates) species; however, the physiological roles of orexin are not well defined. Here, we provide novel evidence that not only is orexin and its related receptors 1/2 (ORXR1/2) expressed in chicken muscle tissue and quail muscle (QM7) cell line, orexin appears to be a secretory protein in QM7 cells. In vitro administration of recombinant orexin A and B (rORX-A and B) differentially regulated prepro-orexin expression in a dose-dependent manner with up-regulation for rORX-A (P < 0.05) and downregulation for rORX-B (P < 0.05) in QM7 cells. While both peptides upregulated ORXR1 expression, only a high dose of rORX-B decreased the expression of ORXR2 (P < 0.05). The presence of orexin and its related receptors and the regulation of its own system in avian muscle cells indicate that orexin may have autocrine, paracrine, and/or endocrine roles. rORXs differentially regulated mitochondrial dynamics network. While rORX-A significantly induced the expression of mitochondrial fission-related genes (DNM1, MTFP1, MTFR1), rORX-B increased the expression of mitofusin 2, OPA1, and OMA1 genes that are involved in mitochondrial fusion. Concomitant with these changes, rORXs differentially regulated the expression of several mitochondrial metabolic genes (av-UCP, av-ANT, Ski, and NRF-1) and their related transcriptional regulators (PPARγ, PPARα, PGC-1α, PGC-1β, and FoxO-1) without affecting ATP synthesis. Taken together, our data represent the first evidence of the presence and secretion of orexin system in the muscle of nonmammalian species and its role in mitochondrial fusion and fission, probably through mitochondrial-related genes and their related transcription factors.

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Intracerebroventricular injection of orexin-A, but not orexin-B, induces arousal of layer-type neonatal chicks

Cited by 23 publications

References 24 publications

Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks

Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks

Central regulation of food intake in mammals and birds: a review

Orexin system is expressed in avian muscle cells and regulates mitochondrial dynamics

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