Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks

Tachibana, Tetsuya; Oikawa, Daichi; Adachi, Nami; Boswell, Tim; Furuse, Mitsuhiro

doi:10.1016/j.cbpa.2007.03.023

Cited by 15 publications

(11 citation statements)

References 23 publications

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“…In addition, chicken GLP-2-induced anorexia was expressed at a very low dose (30 pmol), as well as GLP-1-induced anorexia (Honda et al 2014a). Effects of GLP-2 on plasma concentrations of glucose, NEFA and corticosterone were similar to previous reports showing the effects of GLP-1 (Tachibana et al 2007;Honda et al 2014a). These findings and our results raise the hypothesis that the mechanism underlying the anorexigenic action of GLP-2 is identical to that of GLP-1 in chicks.…”

Section: Discussionsupporting

confidence: 90%

“…Effects of GLP‐2 on plasma concentrations of glucose, NEFA and corticosterone were similar to previous reports showing the effects of GLP‐1 (Tachibana et al . ; Honda et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…Tachibana et al . () reported that intracerebroventricular administration of chicken GLP‐1 significantly decreased plasma glucose concentration and significantly increased plasma NEFA concentration at 60 min after administration. Thus, in order to compare these results, we analyzed the effects of chicken GLP‐2 on plasma components at 60 min after administration.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, central administration of GLP-1 (Honda et al 2014a) or novel glucagon-like peptide (Honda et al 2014b) significantly decreased plasma glucose concentration and did not affect plasma corticosterone concentration at 60 min after administration. Tachibana et al (2007) reported that intracerebroventricular administration of chicken GLP-1 significantly decreased plasma glucose concentration and significantly increased plasma NEFA concentration at 60 min after administration. Thus, in order to compare these results, we analyzed the effects of chicken GLP-2 on plasma components at 60 min after administration.…”

Section: Experiments 2: Effects Of Central Administration Of Chicken Gmentioning

confidence: 97%

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Intracerebroventricular administration of chicken glucagon‐like peptide‐2 potently suppresses food intake in chicks

Honda

Saneyasu

Shimatani

et al. 2014

Animal Science Journal

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Glucagon-related peptides, such as glucagon-like peptide (GLP)-1, GLP-2 and oxyntomodulin (OXM), are processed from an identical precursor proglucagon. In mammals, all of these peptides are suggested to be involved in the central regulation of food intake. We previously showed that intracerebroventricular administration of chicken OXM and GLP-1 significantly suppressed food intake in chicks. Here, we show that central administration of chicken GLP-2 potently suppresses food intake in chicks. Male 8-day-old chicks (Gallus gallus domesticus) were used in all experiments. Intracerebroventricular administration of chicken GLP-2 significantly suppressed food intake in chicks. Plasma glucose concentration was significantly decreased by chicken GLP-2, whereas plasma nonesterified fatty acid concentration was significantly increased. Intracerebroventricular administration of chicken GLP-2 did not affect plasma corticosterone concentration. In addition, the anorexigenic effect of GLP-2 was not reversed by the corticotropin-releasing factor (CRF) receptor antagonist α-helical CRF, suggesting that CRF is not a downstream mediator of the anorexigenic pathway of GLP-2 in chicks. Intracerebroventricular administration of an equimolar amount of GLP-1 and GLP-2, but not OXM, significantly suppressed food intake in both broiler and layer chicks. All our findings suggest that GLP-2 functions as a potent anorexigenic peptide in the brain, as well as GLP-1, in chicks.

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Section: Discussionsupporting

confidence: 90%

“…Effects of GLP‐2 on plasma concentrations of glucose, NEFA and corticosterone were similar to previous reports showing the effects of GLP‐1 (Tachibana et al . ; Honda et al . ).…”

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Experiments 2: Effects Of Central Administration Of Chicken Gmentioning

confidence: 97%

See 2 more Smart Citations

Intracerebroventricular administration of chicken glucagon‐like peptide‐2 potently suppresses food intake in chicks

Honda

Saneyasu

Shimatani

et al. 2014

Animal Science Journal

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show abstract

“…In addition, it appears that chronic central GLP-1R activation results in a shift from using carbohydrates to fatty acids as an energy source, which is consistent with previous studies that showed that chronic i.c.v. GLP-1 treatment decreased the respiratory quotient, indicative of a higher level of fat oxidation by BAT [ 18 , 28 ]. The exendin-4-induced decrease in physical activity, resulting from a diminished food-seeking behaviour [ 29 ], is less likely to contribute to the change in total energy expenditure [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

et al. 2015

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Aims/hypothesisGlucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism, used in the treatment of type 2 diabetes, has recently been shown to increase thermogenesis via the brain. As brown adipose tissue (BAT) produces heat by burning triacylglycerol (TG) and takes up glucose for de novo lipogenesis, the aim of this study was to evaluate the potential of chronic central GLP-1R activation by exendin-4 to facilitate clearance of lipids and glucose from the circulation by activating BAT.MethodsLean and diet-induced obese (DIO) C57Bl/6J mice were used to explore the effect of a 5 day intracerebroventricular infusion of the GLP-1 analogue exendin-4 or vehicle on lipid and glucose uptake by BAT in both insulin-sensitive and insulin-resistant conditions.ResultsCentral administration of exendin-4 in lean mice increased sympathetic outflow towards BAT and white adipose tissue (WAT), resulting in increased thermogenesis as evidenced by increased uncoupling protein 1 (UCP-1) protein levels and decreased lipid content, while the uptake of TG-derived fatty acids was increased in both BAT and WAT. Interestingly, in DIO mice, the effects on WAT were blunted, while exendin-4 still increased sympathetic outflow towards BAT and increased the uptake of plasma TG-derived fatty acids and glucose by BAT. These effects were accompanied by increased fat oxidation, lower plasma TG and glucose concentrations, and reduced body weight.Conclusions/interpretationCollectively, our results suggest that BAT activation may be a major contributor to the glucose- and TG-lowering effects of GLP-1R agonism.

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Glucagon-like peptide 1 (GLP-1) in the gastrointestinal tract of the pheasant (Phasianus colchicus)

et al. 2012

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Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks

Cited by 15 publications

References 23 publications

Intracerebroventricular administration of chicken glucagon‐like peptide‐2 potently suppresses food intake in chicks

Intracerebroventricular administration of chicken glucagon‐like peptide‐2 potently suppresses food intake in chicks

Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

Glucagon-like peptide 1 (GLP-1) in the gastrointestinal tract of the pheasant (Phasianus colchicus)

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