Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats

Souza, Marina F.; Medeiros, Katty A.A.L.; Lins, Lucas Correia; Bispo, José M.M.; Gois, Auderlan M.; Freire, Marco Aurélio M.; Marchioro, Murilo; Santos, José R.

doi:10.1016/j.brainresbull.2019.10.002

Cited by 14 publications

(6 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emerging evidence on the contribution of adult neurogenesis to hippocampal function suggest that dysregulation of neurogenesis by pyrethroid exposure likely contributes to impairments in hippocampal-dependent learning and memory and may have implications for the development of age-related cognitive dysfunction. Taken together, these findings indicate that exposure to deltamethrin insecticide may contribute to disruption of adult hippocampal neurogenesis leading significant deficits in learning and memory in adults, which was further strengthened by the results of others (Souza et al, 2018(Souza et al, , 2020 who observed similar cognitive and behavioral deficits in open field, object recognition, and fear conditioning in adult rats, however, their routes of administration were different (intranasal and intracerebroventricular). Therefore, long-term adult exposure to deltamethrin could increase the risk for the development of cognitive deficits in later life of those occupationally expose to these insecticides.…”

Section: Discussionsupporting

confidence: 61%

Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice

Hossain

Belkadi

Al-Haddad

et al. 2020

Toxicological Sciences

View full text Add to dashboard Cite

Deficits in learning and memory are often associated with disruption of hippocampal neurogenesis, which is regulated by numerous processes, including precursor cell proliferation, survival, migration, and differentiation to mature neurons. Recent studies demonstrate that adult born neurons in the dentate gyrus (DG) in the hippocampus can functionally integrate into the existing neuronal circuitry and contribute to hippocampal-dependent learning and memory. Here, we demonstrate that relatively short-term deltamethrin exposure (3 mg/kg every 3 days for 1 month) inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice. Hippocampal-dependent cognitive functions were evaluated using two independent hippocampal-dependent behavioural tests, the novel object recognition task and Morris water maze. We found that deltamethrin-treated mice exhibited profound deficits in novel object recognition and learning and memory in water maze. Deltamethrin exposure significantly decreased bromodeoxyuridine (BrdU)-positive cells (39%) and Ki67+ cells (47%) in the dentate gyrus (DG) of the hippocampus, indicating decreased cellular proliferation. In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker. Furthermore, deltamethrin exposed mice exhibited a 25% reduction in total number of granule cells in the DG. These findings indicate that relatively short-term exposure to deltamethrin causes significant deficits in hippocampal neurogenesis that is associated with impaired learning and memory.

show abstract

Section: Discussionsupporting

confidence: 61%

Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice

Hossain

Belkadi

Al-Haddad

et al. 2020

Toxicological Sciences

View full text Add to dashboard Cite

show abstract

“…Of the 104 total journal articles reviewed here, 57 investigated the relationship between pesticide exposures in agricultural work and known areas of the brain. Of the 57 articles concerning pesticide exposure, 20 considered all pesticides without mentioning subcategories, nine focused on insecticides [ 96 , 98 , 100 , 104 , 105 , 109 , 113 , 116 , 149 ], six focused on organophosphate pesticides [ 92 , 93 , 95 , 103 , 112 , 117 , 123 , 139 ], three focused on herbicides [ 111 , 133 , 136 ], and the rest focused on either a specific pesticide (e.g., cypermethrin) [ 134 ], or a type of pesticide defined by the type of agriculture where it’s used (e.g., pesticides used on vineyards) [ 137 ]. Because some reviews exist on certain specific types of pesticides, we included all chemicals used to eliminate insects, fungi, and unwanted plants in our definition of pesticides and do not separate them into subgroups below [ 24 , 27 , 42 , 150 , 151 ].…”

Section: Resultsmentioning

confidence: 99%

“…Importantly, there are many more animal studies about the negative effects of pesticides on the brain but only the articles included in this review framed their work in context of agricultural work. An article investigating deltamethrin tested acute exposure on rats similar to the kind of acute exposure that could accidentally happen during agricultural work [ 109 ]. The authors found that acute deltamethrin exposure causes motor and cognitive impairments in rats and may be related to disruption of the dopaminergic pathway, specifically reduction of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta, ventral tegmental area and dorsal striatum [ 109 ].…”

Section: Resultsmentioning

confidence: 99%

“…An article investigating deltamethrin tested acute exposure on rats similar to the kind of acute exposure that could accidentally happen during agricultural work [ 109 ]. The authors found that acute deltamethrin exposure causes motor and cognitive impairments in rats and may be related to disruption of the dopaminergic pathway, specifically reduction of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta, ventral tegmental area and dorsal striatum [ 109 ]. Notably, whereas this study used intracerebroventricular administration of the insecticide, others have used oral ingestion [ 92 , 96 , 103 , 113 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Sturm

Castro

Mendez-Colmenares

et al. 2022

IJERPH

View full text Add to dashboard Cite

Certain exposures related to agricultural work have been associated with neurological disorders. To date, few studies have included brain health measurements to link specific risk factors with possible neural mechanisms. Moreover, a synthesis of agricultural risk factors associated with poorer brain health outcomes is missing. In this systematic review, we identified 106 articles using keywords related to agriculture, occupational exposure, and the brain. We identified seven major risk factors: non-specific factors that are associated with agricultural work itself, toluene, pesticides, heavy metal or dust exposure, work with farm animals, and nicotine exposure from plants. Of these, pesticides are the most highly studied. The majority of qualifying studies were epidemiological studies. Nigral striatal regions were the most well studied brain area impacted. Of the three human neuroimaging studies we found, two focused on functional networks and the third focused on gray matter. We identified two major directions for future studies that will help inform preventative strategies for brain health in vulnerable agricultural workers: (1) the effects of moderators such as type of work, sex, migrant status, race, and age; and (2) more comprehensive brain imaging studies, both observational and experimental, involving several imaging techniques.

show abstract

“…These associations are in line with prior literature on pyrethroids and behavior. For instance, in animals, pyrethroids have been associated with changes in open-field behaviors 18 – 20 and social interactions and emotionality, 19 , 21 along with reduced striatum dopamine levels. 18 , 22 In humans, the literature on pesticide exposures in adulthood and mental illness are scant, although pyrethroid exposure during pregnancy has been suggested to disrupt fetal programming related to mood and behavior.…”

Section: Discussionmentioning

confidence: 99%

Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley

Furlong

Paul

Cockburn

et al. 2020

Environmental Epidemiology

View full text Add to dashboard Cite

Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures in central California, using two waves (PEG 1&2, total N = 1,654) of a case control study of Parkinson’s disease (PD). At enrollment, participants self-reported history of use of depression medications and dates of MD-diagnosed depression and anxiety. Participants also completed a Geriatric Depression Scale-Short Form upon enrollment. We used the California Pesticide Use Registry to assign estimated ambient pyrethroid pesticide exposures at participant’s home addresses over the 5 years before the index date (date of outcome, or an age-matched year for participants without the outcome). We used logistic and linear regression to evaluate associations between living near any pyrethroid applications over the 5-year index period and measures of depression and anxiety. We also evaluated modification by study wave and PD status. We observed associations of pyrethroids with depression, depression medications, and anxiety (adjusted odds ratio [aOR] depression = 1.54, 95% confidence interval [CI] 1.14, 2.07; aOR depression medications = 1.68, 95% CI 1.25, 2.25; aOR anxiety = 1.60, 95% CI 1.17, 2.18). However, we observed no associations with mild/moderate depressive symptoms according to the GDS score at enrollment (aOR = 1.04, 95% CI 0.77, 1.42). We did not observe a consistent modification of the pyrethroid-depression associations by study wave and PD status. Ambient pyrethroid pesticide exposures may be associated with measures of depression in later life.

show abstract

Intracerebroventricular injection of deltamethrin increases locomotion activity and causes spatial working memory and dopaminergic pathway impairment in rats

Cited by 14 publications

References 48 publications

Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice

Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice

Risk Factors for Brain Health in Agricultural Work: A Systematic Review

Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley

Contact Info

Product

Resources

About