Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice

Echeverry, Marcela Bermúdez; Salgado, M. L.; Ferreira, Fabiane Ribeiro; da-Silva, C.A.; Bel, Elaine Aparecida Del

doi:10.1007/s00213-007-0834-8

Cited by 22 publications

(11 citation statements)

References 53 publications

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“…The induction of motor behavior in sGC-KD mice was not detected in the first 5 min of the test (sGCβ1 KD vehicle 714 ± 76 cm; control 621 ± 95 cm; P = 0.12) (Fig. 1I) whereas acute administration of the nitric oxide synthase inhibitor L-NG-nitroarginine methyl ester, (L-NAME) to sGCβ1 KD mice attenuated movement (90 ± 20 cm) as previously shown in WT (8,9), suggesting that extrastriatal NOS are…”

Section: Resultssupporting

confidence: 69%

Nitric oxide regulates synaptic transmission between spiny projection neurons

Sagi

Heiman

Peterson

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance The function of the basal ganglia relies on striatal spiny projecting neurons (SPNs). Axon collaterals of these GABAergic neurons form connections with other SPNs as a means of a feedback inhibition circuit. The mechanisms that regulate neurotransmission at these local synapses remain poorly understood. In this paper, neurotransmission at SPN collaterals is found to be regulated by the gaseous neurotransmitter nitric oxide, which activates a signal-transduction cascade that transcriptionally regulates vesicular GABA transporter specifically at axon collaterals. These findings illustrate a previously unidentified role for nitric oxide in striatal learning and action selection.

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Section: Resultssupporting

confidence: 69%

Nitric oxide regulates synaptic transmission between spiny projection neurons

Sagi

Heiman

Peterson

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…(1991) showed that a high dose of L-NAME (600 mg/kg) had a nearly sedative effect in rats. Moreover, NOS inhibitors N G -nitro-L-arginine (L-NOARG), L-NAME and 7-nitroindazole (7-NI, a relatively selective inhibitor of neuronal NOS) induced catalepsy in mice and rats (Echeverry et al ., 2007; Lazzarini et al ., 2005; Del Bel et al ., 2004). In studies of Volke et al .…”

Section: Involvement Of Nitric Oxide In Animal Behaviourmentioning

confidence: 99%

Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

Sestakova¹,

Púzserová²,

Kluknavsky³

et al. 2013

Interdisciplinary Toxicology

249

139

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In various areas of the bio-medical, pharmacological and psychological research a multitude of behavioural tests have been used to investigate the effects of environmental, genetic and epi-genetic factors as well as pharmacological substances or diseased states on behaviour and thus on the physiological and psycho-social status of experimental subjects. This article is reviewing the most frequently used behavioural tests in animal research (open field, elevated plus maze, zero maze, and black and white box). It provides a summary of common characteristics as well as differences in the methods used in various studies to determine motor activity, anxiety and emotionality. Additionally to methodological aspects, strain, sex and stress-related differences as well as the involvement of nitric oxide in modulation of motor activity and anxiety of rodents were briefly reviewed.

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“…For example, studies by Del Bel et al (2005) have shown that striatal nNOS interneurons play a critical role in the generation of motor behavior. Systemic and intrastriatal exposure to NOS and sGC inhibitors has been shown to depress basal locomotion and induce catalepsy (Stewart et al, 1994; Del Bel et al, 2004; Echeverry et al, 2007). Pharmacological disruption of NO function also potentiates catalepsy induced via D2-class receptor antagonists (Del Bel and Guimaraes, 2000; Cavas and Navarro, 2002).…”

Section: Striatal Pathophysiology In Parkinson's Disease: Involvementmentioning

confidence: 99%

Nitric Oxide–Soluble Guanylyl Cyclase–Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease?

West¹,

Tseng²

2011

Front. Syst. Neurosci.

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Striatal nitric oxide (NO)-producing interneurons play an important role in the regulation of corticostriatal synaptic transmission and motor behavior. Striatal NO synthesis is driven by concurrent activation of NMDA and dopamine (DA) D1 receptors. NO diffuses into the dendrites of medium-sized spiny neurons which contain high levels of NO receptors called soluble guanylyl cyclases (sGC). NO-mediated activation of sGC leads to the synthesis of the second messenger cGMP. In the intact striatum, transient elevations in intracellular cGMP primarily act to increase neuronal excitability and to facilitate glutamatergic corticostriatal transmission. NO–cGMP signaling also functionally opposes the inhibitory effects of DA D2 receptor activation on corticostriatal transmission. Not surprisingly, abnormal striatal NO–sGC–cGMP signaling becomes apparent following striatal DA depletion, an alteration thought to contribute to pathophysiological changes observed in basal ganglia circuits in Parkinson's disease (PD). Here, we discuss recent developments in the field which have shed light on the role of NO–sGC–cGMP signaling pathways in basal ganglia dysfunction and motor symptoms associated with PD and l-DOPA-induced dyskinesias.

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Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice

Cited by 22 publications

References 53 publications

Nitric oxide regulates synaptic transmission between spiny projection neurons

Nitric oxide regulates synaptic transmission between spiny projection neurons

Determination of motor activity and anxiety-related behaviour in rodents: methodological aspects and role of nitric oxide

Nitric Oxide–Soluble Guanylyl Cyclase–Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease?

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