Intracerebroventricular Administration of Ghrelin Rapidly Suppresses Pulsatile Luteinizing Hormone Secretion in Ovariectomized Rats

Furuta, Miyako; Funabashi, Toshiya; Kimura, Fukuko

doi:10.1006/bbrc.2001.5854

Cited by 208 publications

(142 citation statements)

References 49 publications

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“…These studies showed that central administration of ghrelin suppressed pulsatile LH secretion in ovariectomized female rats (Furuta et al, 2001).…”

Section: Control Of the Hypothalamic-pituitary-gonadal Axis: Animal Smentioning

confidence: 97%

“…The effects of ghrelin upon gonadotropins and PRL secretion have been explored in a limited number of models and animal species, including rats, primates and sheep (Fernández-Fernández et al, 2004;Fernández-Fernández et al, 2005a;Furuta et al, 2001;Harrison et al, 2008;Iqbal et al, 2006;Kluge et al, 2007;Lanfranco et al, 2008;Vulliémoz et al, 2004). These studies showed that central administration of ghrelin suppressed pulsatile LH secretion in ovariectomized female rats (Furuta et al, 2001).…”

Section: Control Of the Hypothalamic-pituitary-gonadal Axis: Animal Smentioning

confidence: 99%

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Ghrelin and reproductive disorders

Repaci

Gambineri

Pagotto

et al. 2011

Molecular and Cellular Endocrinology

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Ghrelin is an important factor involved in most of the metabolic and hormonal signals which adapt the reproductive functions in conditions of altered energy balance. Moreover, the coordinated role of leptin and ghrelin appears in fact to have a specific role in the regulation of puberty. Systemic action of ghrelin on the reproductive axis involves the control of the hypothalamic-pituitary-gondal axis. In addition, it has been shown that ghrelin may directly act at a gonadal level in both females and males. Available data also demonstrate that sex steroid hormones and gonadotropins may in turn regulate the gonadal effect of ghrelin, as documented by studies performed in females with the polycystic ovary syndrome and in hypogonadal men. Notably, recent studies also confirm a potentially important role for ghrelin in fetal and neonatal energy balance, and specifically in allowing fetal adaptation to an adverse intrauterine environment.

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“…These studies showed that central administration of ghrelin suppressed pulsatile LH secretion in ovariectomized female rats (Furuta et al, 2001).…”

Section: Control Of the Hypothalamic-pituitary-gonadal Axis: Animal Smentioning

confidence: 97%

Section: Control Of the Hypothalamic-pituitary-gonadal Axis: Animal Smentioning

confidence: 99%

Ghrelin and reproductive disorders

Repaci

Gambineri

Pagotto

et al. 2011

Molecular and Cellular Endocrinology

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show abstract

“…Unlike the anorexigenic peptides insulin and leptin, which promote GNRH/LH pulsatility and reproductive function, the orexigenic peptide ghrelin has been shown to consistently suppress GNRH pulsatility and gonadotropin release (Furuta et al 2001, Kluge et al 2007, Kluge 2012. Although ghrelin is predominantly produced in the stomach, ghrelinexpressing neurons have also been identified in the hypothalamus (Cowley et al 2003), yet it remains unclear whether the actions of brain-derived ghrelin are the same as those for circulating ghrelin.…”

Section: Ghrelinmentioning

confidence: 99%

Neuroendocrine integration of nutritional signals on reproduction

Evans

Anderson

2017

Journal of Molecular Endocrinology

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Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that drive reproductive function. The metabolically relevant hormones leptin, insulin and ghrelin have been identified as key mediators of this 'metabolic control of fertility'. However, the neural circuitry through which they act to exert their control over GNRH drive remains incompletely understood. With the advent of Cre-LoxP technology, it has become possible to perform targeted gene-deletion and gene-rescue experiments and thus test the functional requirement and sufficiency, respectively, of discrete hormone-neuron signaling pathways in the metabolic control of reproductive function. This review discusses the findings from these investigations, and attempts to put them in context with what is known from clinical situations and wild-type animal models. What emerges from this discussion is clear evidence that the integration of nutritional signals on reproduction is complex and highly redundant, and therefore, surprisingly difficult to perturb. Consequently, the deletion of individual hormone-neuron signaling pathways often fails to cause reproductive phenotypes, despite strong evidence that the targeted pathway plays a role under normal physiological conditions. Although transgenic studies rarely reveal a critical role for discrete signaling pathways, they nevertheless prove to be a good strategy for identifying whether a targeted pathway is absolutely required, critically involved, sufficient or dispensable in the metabolic control of fertility.

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“…Both ghrelin and GRLN-R (a G-protein-coupled receptor) are widely expressed throughout human tissue [19,28]. Thus, in addition to control of GH secretion, ghrelin serves to regulate diverse digestive processes [22], energy homeostasis and food intake [29,30], and numerous other systems (reviewed in 19,28) including the immune system [31]], reproductive system [32], cardiovascular system [3334], adrenal glands, neoplastic proliferation, and osteoblastic function [35]. Regulation of energy homeostasis by ghrelin has made ghrelin an appealing target for treatment of metabolic disorders including obesity and type 2 diabetes.…”

Section: The Role Of Ghrelinmentioning

confidence: 99%

Therapeutic Applications of Ghrelin Agonists in the Treatment of Gastroparesis

Shin

2015

Curr Gastroenterol Rep

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There remains an unmet need for effective pharmacologic treatments for gastroparesis.Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and has been shown to regulate energy homeostasis and exert prokinetic effects on gastrointestinal motility. In recent years, several ghrelin receptor agonists have been studied in clinical trials of patients with diabetic gastroparesis. The intravenous macrocyclic peptidomimetic, TZP-101 initially suggested improvement in gastroparesis symptoms with intravenous administration when compared to placebo. However, in subsequent studies of oral preparations, TZP-102 failed to confirm these results. Another ghrelin receptor agonist, RM-131 was recently shown to significantly accelerate gastric emptying (GE) in patients with type 1 and type 2 diabetes and delayed GE. RM-131 reduced total Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD) and composite scores among type 1 diabetics. Continued development of ghrelin agonists should be explored in attempts to expand therapeutic options for the treatment of gastroparesis.

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Intracerebroventricular Administration of Ghrelin Rapidly Suppresses Pulsatile Luteinizing Hormone Secretion in Ovariectomized Rats

Cited by 208 publications

References 49 publications

Ghrelin and reproductive disorders

Ghrelin and reproductive disorders

Neuroendocrine integration of nutritional signals on reproduction

Therapeutic Applications of Ghrelin Agonists in the Treatment of Gastroparesis

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