Intracerebral, Possibly Malignant Osteochondrofibroma in a Child

Mesenchymal Chondrosarcoma

“…BENIGN TUMOURS The infrequency of intracranial cartilaginous tumours is emphasized by the fact that Cushing (1931) mentioned only three cartilaginous tumours in his series of 2,000; Dowman and Smith (1928) found none in 100; Leitholf (1956) reported four in 4,399; and Van Wagenen (1934) none in 149 brain tumours. According to Flyger et al (1963) a total of 40 chondromatous or osteochondromatous primary intracranial tumours had been reported before 1963. Sporadic reports occurred early in this century (Bevan and Gill, 1919) and in thepast three decades there have been only a few isolated reports of such tumours (Smitt, 1929;Brutt, 1931;Froment, Wertheimer, and Dechaume, 1932;Verbrugghen and Learmonth, 1932;Austoni, 1936;Baker and Adams, 1937;Chorobski et al, 1939;Siris and Angrist, 1942;Money, 1943;Forsythe, Baker, Dockerty, and Camp, 1947;Obrador and Soto, 1953;David and Constans, 1957;Leitholf, (1956) quoted by Roukkula, 1964;Lichtenstein, and Bernstein, 1959;Flyger et al, 1963;and Roukkula, 1964).…”

“…Since that time, and including our case, three more have been added (Gorman, 1960;Ramamurthi, Iyer, and Vedachalam, 1961;Geuna and Gori, 1962) for a total of 29. In the English literature, Chorobski and co-workers intracranial cartilaginous tumours are summarized by Flyger et al (1963) as follows: 'They occur principally in males age 18 to 65, some originate in the base of the skull, but some are not connected with skull bones. Almost all are attached to the dura or falx, but sometimes there is no demonstrable connection with the meninges.…”

Diagnostic pitfall in the diagnosis of mesenchymal chondrosarcoma arising in the central nervous system

“…6 Second, most reported primary CNS Ewing sarcoma/ PNET are extra-axial, dural-based masses. 16 Histologically, the small round cell appearance in Ewing sarcoma/PNET shows a striking histological similarity to mesenchymal chondrosarcoma, both exhibiting sheets of small round [19] 44/F Parietal Dura GTR Died, 9 years (9 recurrences) 2 [20] 11/M Frontal Parenchyma GTR Alive, 5 months 3 [21] 48/F Frontal Parenchyma R Died, 3 days 4 [22] 18/F Frontal Dura STR Died, 16 months (4 recurrences) 5 [23] 51/F Parietal Dura STR, RT Died, 11 months (1 recurrence, metastasis) 6 [24] 13/M Frontoparietal Dura GTR Alive, 1.5 years 7 [25] 19/M Parietal Dura R, RT Alive, 1 year (1 recurrence) 8 [26] 19/M Occipital Dura GTR Unknown 9 [9] 7/M Temporal Dura R Alive, 7 years (1 recurrence) 10 [9] 17/F Frontal Dura R Died, 2 years 11 [9] 40/M Parietal Dura R Died, 5 days 12 [27] 11/M Parietooccipital Dura STR Alive, 8 years (1 recurrence, metastasis) 13 [28] 33/M Frontal Dura R Alive, 3 years (2 recurrences) 14 [28] 26/F Frontal Dura GTR Died, 3 days 15 [28] 23/F Parietal Dura R, RT Alive, 4.5 years 16 [28] 26/F Cerebellar Parenchyma R Alive, 2.5 years 17 [29] 11/F Biparietal Dura GTR, RT Died, 18 years 18 [30] 22/M Cerebellar Parenchyma R Died, 4 months (1 recurrence) 19 [31] 19/M Parietal Dura R, RT Alive, 12 months (1 recurrence) 20 [31] 21/F Frontal Dura R Died, 7 years (metastasis) 21 [32] 12/F Frontal Parenchyma GTR Died, 5 months (1 recurrence) 22 [33] 61/F Parietal Dura R, RT Alive, unknown 23 [34] 6/F Thalamus Parenchyma None Died, 8 years 24 [35] 11/F Parietal Parenchyma R, RT Died, 1.5 years (1 recurrence) 25 [36] 13/F Frontoparietal Dura GTR Alive, 3 years (1 recurrence) 26 [37] 11 months/M Frontal Dura R, RT Died, unknown 27 [37] 12/F Frontal Dura R, CT, RT Died, unknown (1 recurrence) 28 [38] 5/M Frontal Dura GTR, RT Alive, 14 months 29 [38] 7/F Sphenoid ridge Dura STR D...…”

Mesenchymal Chondrosarcoma

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Primary intracranial cartilaginous neoplasms which do not arise from bones of the skull are extremely rare (Alpers, 1935;Chorobski, Jarzymski, and Ferens, 1939;Dahlin and Henderson, 1962;Flyger, Freidenfeldt, and Orell, 1963;Siris and Angrist, 1942). We report herein two such tumours; one benign and the other malignant.

CASE 1: CHONDROMA During the seventh month of pregnancy L.W., a 32-yearold white woman, began to exp-rience fainting spells of 15 minutes' duration followed by increasingly severe speech difficulty and weakness in the right arm.

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“…DISCUSSION BENIGN TUMOURS The infrequency of intracranial cartilaginous tumours is emphasized by the fact that Cushing (1931) mentioned only three cartilaginous tumours in his series of 2,000; Dowman and Smith (1928) found none in 100; Leitholf (1956) (Bevan and Gill, 1919) and in thepast three decades there have been only a few isolated reports of such tumours (Smitt, 1929;Brutt, 1931;Froment, Wertheimer, and Dechaume, 1932;Verbrugghen and Learmonth, 1932;Austoni, 1936;Baker and Adams, 1937;Chorobski et al, 1939;Siris and Angrist, 1942;Money, 1943;Forsythe, Baker, Dockerty, and Camp, 1947;Obrador and Soto, 1953;David and Constans, 1957;Leitholf, (1956) quoted by Roukkula, 1964;Lichtenstein, and Bernstein, 1959;Flyger et al, 1963;and Roukkula, 1964). …”