Intracerebral neurocysticercosis mimicking glioblastoma multiforme: a rare differential diagnosis in Central Europe

Sabel, Michael; Neuen-Jacob, Eva; Vogt, Christoph; Weber, Friedrich

doi:10.1007/s002340000474

Cited by 26 publications

(8 citation statements)

References 14 publications

(22 reference statements)

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“… Notes: Cases reported from Austria [39], Luxemburg [23], Norway [59], Switzerland [29], two case from Germany [31], [38] and one case from Spain [61] were diagnosed in subjects who travelled to or resided in other European countries. Concerning 348 cases reported from Portugal [34], the authors do not specify whether all cases are autochthonous, but state in the introduction that the catchment area of the hospital is highly endemic (district of Oporto and north inland).…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and Management of Cysticercosis and Taenia solium Taeniasis in Europe, Systematic Review 1990–2011

et al. 2013

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BackgroundCysticercosis is caused by the invasion of human or pig tissues by the metacestode larval stage of Taenia solium. In Europe, the disease was endemic in the past but the autochthonous natural life cycle of the parasite is currently completed very rarely. Recently, imported cases have increased in parallel to the increased number of migrations and international travels. The lack of specific surveillance systems for cysticercosis leads to underestimation of the epidemiological and clinical impacts.ObjectivesTo review the available data on epidemiology and management of cysticercosis in Europe.MethodsA review of literature on human cysticercosis and T. solium taeniasis in Europe published between 1990–2011 was conducted.ResultsOut of 846 cysticercosis cases described in the literature, 522 cases were autochthonous and 324 cases were imported. The majority (70.1%) of the autochthonous cases were diagnosed in Portugal from 1983 and 1994. Imported cases of which 242 (74.7%) diagnosed in migrants and 57 (17.6%) in European travellers, showed an increasing trend. Most of imported cases were acquired in Latin America (69.8% of migrants and 44.0% of travellers). The majority of imported cases were diagnosed in Spain (47.5%), France (16.7%) and Italy (8.3%). One third of neurosurgical procedures were performed because the suspected diagnosis was cerebral neoplasm. Sixty eight autochthonous and 5 imported T. solium taeniasis cases were reported.ConclusionsCysticercosis remains a challenge for European care providers, since they are often poorly aware of this infection and have little familiarity in managing this disease. Cysticercosis should be included among mandatory reportable diseases, in order to improve the accuracy of epidemiological information. European health care providers might benefit from a transfer of knowledge from colleagues working in endemic areas and the development of shared diagnostic and therapeutic processes would have impact on the quality of the European health systems.Key words: cysticercosis, neurocysticercosis, Taenia solium, taeniasis, Europe, travellers, migrants.

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Section: Resultsmentioning

confidence: 99%

Epidemiology and Management of Cysticercosis and Taenia solium Taeniasis in Europe, Systematic Review 1990–2011

et al. 2013

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“…It has been reported that tumor-related angiogenesis and microvascular extravasation due to blood-brain barrier (BBB) disruption are the driving forces of cyst formation (3)(4)(5). Neurocysticercosis (NCC) is an infectious disease of the nervous system caused by the Taenia solium larvae (cysticerci) (6)(7)(8). Contaminated food and water are the major sources of this infection, causing severe headache and seizures in addition to pathological manifestations (9).…”

Section: Introductionmentioning

confidence: 99%

Rapid increase in cystic volume of an anaplastic astrocytoma misdiagnosed as neurocysticercosis: A case report

Han

Feng

2016

Oncology Letters

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Abstract. Reports describing a rapid increase in the cystic volume of anaplastic astrocytoma (AA) in a short time frame are rare. The present study reports the case of a 68-year-old male who was admitted to the No. 9 People's Hospital, Shanghai Jiaotong University School of Medicine (Shanghai, China), with a small cystic brain lesion and positive immunological testing for cysticercosis. Head magnetic resonance imaging (MRI) showed a cystic lesion, 6 mm in diameter, in the left frontal lobe. Neurocysticercosis was suspected and the patient was treated with a clinical trial of albendazole and steroids. A period of 25 days later, the patient's condition had deteriorated, and MRI revealed a cystic lesion in the left frontal lobe; thereafter, the cystic lesion was removed and a diagnosis of AA was established. The tumor was soft, ivory white and gelatinous due to myxoid degeneration. In this case, tumor-related angiogenesis and microvascular extravasation (blood-brain barrier disruption) may have been the main cause of the rapid increase in the cystic volume in such a short time frame. The similarity of the glioma and cysticercus antigens may have been the cause of the positive reactions in the cystic fluid. The present study reports the rare occurrence of a rapid increase of cystic volume and potential diagnostic difficulties.

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“…2 Single, large racemose cysticercus may be difficult to differentiate from neoplastic condition. 3 Racemose NCC may present with symptoms of increased intracranial pressure and can mimic high-grade glioma radiologically. This atypical presentation of this common disease is extremely rare, and only few case reports are available in the published literature, with surgical management having good outcome.…”

Section: Introductionmentioning

confidence: 99%

Racemose Neurocysticercosis Masquerading High-Grade Glial Neoplasm: A Rarest Presentation of Common Disease

Kumar

Singh

2016

IJNS

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We are presenting a case of racemose neurocysticercosis presented with symptoms of increased intracranial pressure and radiologically mimicking high-grade glioma, which was managed surgically with good recovery. Neurocysticercosis is the commonest parasitic disease of the human nervous system having pleomorphic clinical manifestations, which depend on the location, number, and stage of the cysts at presentation. Atypical presentation of cerebral cysticercosis may mimic glioma and may be difficult to differentiate from neoplastic condition. Differ from the usual medical management, they may require urgent surgical intervention.

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Intracerebral neurocysticercosis mimicking glioblastoma multiforme: a rare differential diagnosis in Central Europe

Cited by 26 publications

References 14 publications

Epidemiology and Management of Cysticercosis and Taenia solium Taeniasis in Europe, Systematic Review 1990–2011

Epidemiology and Management of Cysticercosis and Taenia solium Taeniasis in Europe, Systematic Review 1990–2011

Rapid increase in cystic volume of an anaplastic astrocytoma misdiagnosed as neurocysticercosis: A case report

Racemose Neurocysticercosis Masquerading High-Grade Glial Neoplasm: A Rarest Presentation of Common Disease

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