Intracerebral hogkin's lymphoma in a patient with human immunodeficiency virus

García‐Noblejas, Ana; Nieto, Santiago; Liberal, Rodrigo; Cannata, Jimena; Steegmann, Juan Luis; Fernández-Rañada, JM; Arranz, Reyes

doi:10.3324/haematol.11291

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…[4][5][6] We present the case of an HIV-seropositive patient with intracerebral progression of Hodgkin lymphoma after administration of systemic chemotherapy. [8][9][10][11] This case report highlights the frequent diagnostic dilemmas and diffi culties encountered in the management of patients presenting with symptoms emanating from CNS pathology and underlines the need for less invasive and more sophisticated diagnostic tests for intracerebral Hodgkin lymphoma. 7 This includes recurrent and/or newly diagnosed cases in either immunocompromised or immunocompetent patients.…”

Section: Introductionmentioning

confidence: 90%

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Intracerebral Progression of Hodgkin Lymphoma in a Man with HIV

Saloura

Grivas

Mapow

et al. 2009

Postgraduate Medicine

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Intracerebral relapse of Hodgkin lymphoma is a rare occurrence, with a reported incidence of < 0.5%. To the best of our knowledge, only 4 cases have been reported in the literature. We report the case of a human immunodeficiency virus (HIV)-seropositive man with disseminated Hodgkin lymphoma who presented with left facial weakness and sensory abnormalities as the only symptoms of disease progression 3 months after chemotherapy-induced disease remission. Because of the relative rarity of the condition, there are no randomized controlled trials or evidence-based strategies for managing patients with HIV and intracerebral Hodgkin lymphoma. The diagnostic difficulty of this case emphasizes the necessity for a high index of suspicion for the diagnosis of HIV-associated intracerebral lymphoma in the appropriate clinical setting. In the post-genomic era, the development of sophisticated clinical and/or molecular biomarkers could contribute to earlier diagnosis and potentially improve disease prognosis.

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Section: Introductionmentioning

confidence: 90%

“…[8][9][10][11] The fi rst report was described in 1991, and in all cases, intracranial involvement occurred after chemotherapyinduced disease remission. [8][9][10][11] The fi rst report was described in 1991, and in all cases, intracranial involvement occurred after chemotherapyinduced disease remission.…”

Section: Hodgkin Lymphoma In a Man With Hivmentioning

confidence: 99%

Intracerebral Progression of Hodgkin Lymphoma in a Man with HIV

Saloura

Grivas

Mapow

et al. 2009

Postgraduate Medicine

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“…In an extensive review of the English literature from 1952 to 1999, Nakayama et al described 25 reports communicating 48 cases [7]. In addition, 31 new cases have been described between 2000 and 2009 [2,4,5,[8][9][10][11][12][13][14]. Primitive HL of the CNS is even rarer.…”

Section: Development Of Hl In the Cns Is A Very Infrequent Eventmentioning

confidence: 98%

“…Other suggested explanations are the direct spread from dural or osseous deposits, the direct propagation from metastatic lymph nodes in the neck through the skull base foramina or the development of in situ HL by means of neoplastic transformation of lymphoreticular tissue [18]. Risk factors for developing CNS HL are not clearly determined, although many authors have suggested a role for immunosuppressant status, an association with Epstein-Barr virus or with the human immunodefi ciency virus or in cases of familial Hodgkin's disease [2,12,15]. However, as in the case with the patient reported here, intracranial HL has also been described in immunocompetent patients [3].…”

Section: Development Of Hl In the Cns Is A Very Infrequent Eventmentioning

confidence: 99%

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Cerebellar involvement in Hodgkin’s lymphoma: an atypical site of relapse

et al. 2010

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The presentation of intracranial metastases from Hodgkin's lymphoma is an infrequent event that worsens clinical outcome. A case of Hodgkin's lymphoma relapse in the cerebellum is described in a 70-year-old woman with a previously treated stage IVA Hodgkin's lymphoma. Diagnostic workup and treatment strategies for central nervous system relapses are reviewed and discussed. A combination of surgery, radiotherapy and occasionally chemotherapy remains the most appropriate approach to intracranial Hodgkin's lymphoma.

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Unusual clinico-pathological features in primary Hodgkin’s lymphomas of the central nervous system

et al. 2012

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Primary Hodgkin's lymphomas of the central nervous system (CNS) as well as cerebral involvement as the first manifestation of a systemic Hodgkin's disease are very rare. CNS involvement usually occurs in patients with advanced or relapsing systemic disease. Because primary CNS Hodgkin's lymphoma may present unexpected and sometimes misleading clinical and neuroradiological features, the description of unusual cases is important for expanding the awareness of this rare disease of the central nervous system. We describe three cases of primary Hodgkin's lymphoma of the CNS with peculiar features. None of the three patients had a previous clinical history of systemic Hodgkin disease. Case 1 and case 2 presented an unusual localization in the cerebellar hemisphere and in the brainstem, respectively. The third case occurred as a temporal lesion in the settings of a Richter transformation of a chronic lymphocytic leukemia.

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Intracerebral hogkin's lymphoma in a patient with human immunodeficiency virus

Cited by 7 publications

References 12 publications

Intracerebral Progression of Hodgkin Lymphoma in a Man with HIV

Intracerebral Progression of Hodgkin Lymphoma in a Man with HIV

Cerebellar involvement in Hodgkin’s lymphoma: an atypical site of relapse

Unusual clinico-pathological features in primary Hodgkin’s lymphomas of the central nervous system

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