Intracerebral hemorrhage as a rare complication of imatinib in a Philadelphia chromosome positive acute lymphoblastic leukemia pediatric patient

Choi, Sujin; Choi, Jung Yoon; Kim, Bo Kyung; Ahn, Hong Yul; Hong, Kyung Taek; Cheon, Jung Eun; Shin, Hee Young; Kang, Hyoung Jin

doi:10.1080/08880018.2020.1843577

Cited by 2 publications

(1 citation statement)

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“…Compared with non-HAML patients, HAML patients were more likely to have abnormal coagulation function and were more likely to be accompanied by hemorrhage complications, gene mutations, and chromosomal karyotypes with poor prognoses. Hemorrhage may occur in either acute lymphocytic leukemia (ALL) or AML [ 17 – 19 ]. The hemorrhages in HAML patients were associated with abnormal coagulation function in our present study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors of Coagulation Dysfunction and Hemorrhage in Newly Diagnosed Hyperleukocytic Acute Myeloma Leukemia

Liu

Zhou

2022

Contrast Media & Molecular Imaging

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Purpose. To explore whether and why abnormal coagulation function and hemorrhage can appear in patients with hyperleukocytic acute myeloid leukemia (HAML). Method. We retrospectively reviewed the charts of 724 acute myeloid leukemia (AML) patients admitted with a white blood cell count of >100 × 109/L between 2010 and 2019 in order to analyze the coagulation index of patients with HAML and explore the correlation of abnormal coagulation. Result. Prothrombin time (PT) was extended in group HAML compared with group non-HAML. Respiratory failure, intracranial hemorrhage, and infection were more common in the HAML group. Among the 76 HAML patients, there were 33 patients who had ≥3 abnormal items of coagulation index, and 51.5% of them had level 2 hemorrhage which was more than level 0 hemorrhage, and the difference is statistically significant P < 0.01 . Similarly, we can discover that 40.9% of patients with 2 abnormal items had level 2 hemorrhage in contrast to 0 abnormal items. The use of hydroxyurea had a significant effect on PT and D-dimer (DD). Survival analysis by the Kaplan–Meier method showed that there were statistically significant differences in white blood cell (WBC) count＞200 × 109//L and DD. Abnormal PT is associated with WBC count＞200 × 109//L, and abnormal activated partial thromboplastin time (APTT) is associated with HLA-DR mutation. Infection and respiratory failure were independent influencing factors for the coagulation of patients. Conclusion. DD had a marked effect on the survival rate. Infection and respiratory failure were independent influencing factors for the coagulation of patients.

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Section: Discussionmentioning

confidence: 99%