Intracerebral electrical stimulation of a face-selective area in the right inferior occipital cortex impairs individual face discrimination

Jonas, Jacques; Rossion, Bruno; Krieg, Julien; Koessler, Laurent; Colnat-Coulbois, Sophie; Vespignani, Hervé; Jacques, Corentin; Vignal, Jean Pierre; Brissart, Hélène; Maillard, Louis

doi:10.1016/j.neuroimage.2014.06.017

Cited by 61 publications

(64 citation statements)

References 55 publications

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“…Indeed, in patients of acquired prosopagnosia (an inability to recognize faces) due to the lesion of OFA, a lack of RS has been found in the FFA (Schiltz et al 2006;Steeves et al 2009), suggesting its functional relevance. Furthermore, another study, measuring intracerebral EEG, found strong RS for face identity in the right OFA on an electrode, whose stimulation disrupted behavioral face discrimination (Jonas et al 2014). …”

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confidence: 99%

The relationship between repetition suppression and face perception

Hermann

Grotheer

Kovács

et al. 2016

Brain Imaging and Behavior

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confidence: 99%

The relationship between repetition suppression and face perception

Hermann

Grotheer

Kovács

et al. 2016

Brain Imaging and Behavior

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“…Because of the very high frequency resolution, the analysis used here is highly resistant to (intracerebral) artifacts (mainly epileptic spikes), which are more broadly distributed across the frequency spectrum than the specific frequencies of visual stimulation (37,42). Nevertheless, to test for the robustness of the results, we performed the same quantification analysis after artifact rejection (SI Text).…”

Section: Resultsmentioning

confidence: 99%

“…However, even when large samples of participants are tested, face-selective responses are broadly distributed in the VOTC, without evidence of a clustered organization as found in fMRI (27,30,34). Thus, even though a good correlation between fMRI and iEEG face-selective responses has been shown in specific cortical regions of a few participants (35)(36)(37)(38)(39), the dominant role of the posterior fusiform gyrus (FG) and inferior occipital gyrus (IOG), and of the right hemisphere, in face categorization, has never been validated by direct measures of neural activity. More generally, although iEEG recordings do not suffer from regional variations in SNR, direct neural face-selective responses have not been localized, quantified, and compared across anatomical regions of the human VOTC.…”

Section: Significancementioning

confidence: 92%

“…The main advantages of this approach are its extremely high SNR, providing significant responses in a few minutes of stimulation or less, and its objectivity: The neural response of interest concentrates in the EEG exactly and exclusively at the known frequency rate of stimulation and its harmonics (42,43). To our knowledge, the application of this approach in intracerebral recordings is rare (37,44) and has not been used to address the issue of category selectivity.…”

Section: Significancementioning

confidence: 99%

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A face-selective ventral occipito-temporal map of the human brain with intracerebral potentials

Jonas

Jacques²,

Liu‐Shuang³

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Human neuroimaging studies have identified a network of distinct face-selective regions in the ventral occipito-temporal cortex (VOTC), with a right hemispheric dominance. To date, there is no evidence for this hemispheric and regional specialization with direct measures of brain activity. To address this gap in knowledge, we recorded local neurophysiological activity from 1,678 contact electrodes implanted in the VOTC of a large group of epileptic patients (n = 28). They were presented with natural images of objects at a rapid fixed rate (six images per second: 6 Hz), with faces interleaved as every fifth stimulus (i.e., 1.2 Hz). High signal-to-noise ratio face-selective responses were objectively (i.e., exactly at the face stimulation frequency) identified and quantified throughout the whole VOTC. Face-selective responses were widely distributed across the whole VOTC, but also spatially clustered in specific regions. Among these regions, the lateral section of the right middle fusiform gyrus showed the largest face-selective response by far, offering, to our knowledge, the first supporting evidence of two decades of neuroimaging observations with direct neural measures. In addition, three distinct regions with a high proportion of face-selective responses were disclosed in the right ventral anterior temporal lobe, a region that is undersampled in neuroimaging because of magnetic susceptibility artifacts. A high proportion of contacts responding only to faces (i.e., "face-exclusive" responses) were found in these regions, suggesting that they contain populations of neurons involved in dedicated face-processing functions. Overall, these observations provide a comprehensive mapping of visual category selectivity in the whole human VOTC with direct neural measures.face perception | intracerebral recordings | fast periodic visual stimulation | face selectivity | fusiform gyrus

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“…It has been reported that in the absence of contribution from the rOFA, the rFFA does not discriminate individual faces properly (Schiltz et al 2006;Dricot et al 2008). Recent experiments found that intracranial electrical stimulation of the rOFA as well as the rFFA elicits transient effects similar to symptoms of prosopagnosia, including impairments in face matching and recognition, as well as perceived distortions of the face stimulus (Jonas et al 2012(Jonas et al , 2014.…”

Section: Introductionmentioning

confidence: 99%