Intracerebral chloroma complicating acute monocytic leukemia

Abstract

We present the case of a 21-year-old woman with an acute monocytic leukemia. When she was in complete hematological remission, she developed rapid progressive hemiparesis on the right caused by a left frontoparietal chloroma as confirmed by surgery and histological examination. Postoperatively, the patient recovered completely, and x-ray therapy followed. Since intracerebral myeloblastic tumors are extremely rare and since the neurosurgeon may be involved in treatment of these lesions, we are encouraged to present our findings.

Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature

“…Convulsions, cranial nerve palsies, papilloedema, cerebellar deficits, hemiparesis and aphasia have been reported. 11,14,16,23,31,34 Radicular pain, numbness and weakness of the extremities have also been reported in spinal involvements. 24,35 The lesions are iso-or hyperdense with surrounding edema on pre-contrast computed tomography (CT) studies and they intensely enhance after contrast injection.…”

“…There are few cases of intracranial granulocytic sarcoma from skull, dura or leptomeningeal invasion. 1,[5][6][7]11,22,23,[25][26][27][28][29][30][31][32][33][34] Moreover, intracranial granulocytic sarcoma without meningeal or skull invasion is extremely rare; nine pathologically proven cases have been reported in the literature. 8,[14][15][16][17][18][19][20][21] Clinical data regarding these patients, including ours, are summarized in Table 1.…”

Coincidence of Recurrent Hemiparesis and Detection of ALL in a 4-Year-Old Girl: One or Two Diseases?

“…Another manifestation of CNS leukemia is cerebral chloroma (granulocytic sarcoma), which can manifest with stroke symptoms [14] . Chloromas can be seen in MRI as demarcated tumors and are often associated with eosinophilia [7] .…”