Intracerebral cavernous hemangioma with angiographically demonstrated pathologic vasculature

Jonutis, A. J.; Sondheimer, Fred K.; Klein, Harold P.; Wise, Burton L.

doi:10.1007/bf00339895

Cited by 46 publications

(15 citation statements)

References 13 publications

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“…To be detected by radionuclide scanning the lesion must have a diameter of at least 20 mm [Kawi, 19781; with routine angiography only a subtle blush or unusual venous drainage pattern may be apparent [Kramer, 1977;Voigt, 1976;Kawi, 1978;Numaguchi, 1977;Bartlett, 1977;Jonutis, 1971;Segall, 19741 although selective, high dose, prolonged angiography may be useful [Numaguchi, 19791. CCT scanning has dramatically improved the detection rate [Kramer, 1977;Bartlett, 19791 and confirmed the pathologists' suspicion that these lesions are not rare occurrences [Russell, 19711.…”

Section: Managementmentioning

confidence: 99%

“…The vascular anomaly produced by the FCA mutation has received little attention in the past because individual lesions were difficult to detect on routine angiograms, pneumoencephalograms or skull radiographs. To be detected by radionuclide scanning the lesion must have a diameter of at least 20 mm [Kawi, 19781; with routine angiography only a subtle blush or unusual venous drainage pattern may be apparent [Kramer, 1977;Voigt, 1976;Kawi, 1978;Numaguchi, 1977;Bartlett, 1977;Jonutis, 1971;Segall, 19741 although selective, high dose, prolonged angiography may be useful [Numaguchi, 19791. CCT scanning has dramatically improved the detection rate [Kramer, 1977;Bartlett, 19791 and confirmed the pathologists' suspicion that these lesions are not rare occurrences [Russell, 19711. Moreover, as demonstrated here, CCT can be particularly useful in detecting bleeding lesions in functionally silent areas (eg, frontal lobe) and small nonhemorrhagic lesions not clinically apparent, though located in critical areas of the brain. The relatively high incidence of clinical symptoms and the ease of surgical removal underscore the importance of correctly diagnosing the lesion.…”

Section: Managementmentioning

confidence: 99%

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Familial cavernous angiomas: Natural history and genetic study over a 5‐year period

et al. 1982

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In a kindred of 122 individuals we found 5 individuals with cerebral vascular malformation, 3 representing typical cavernous angiomas. The condition was inherited as an autosomal dominant trait with variable expressivity. Forty-three relatives were examined prospectively by cranial computed tomography (CCT) and lesions were found in 15; 7 were followed prospectively with CCT scans for 5 years. Angiography in 5 of these cases failed to demonstrate the lesion. In 3 patients with previously normal CCT scans a change in blood volume or membrane permeability allowed visualization of the lesion on contrast scans. In 2 individuals, both parents of affected children, a normal CCT scan was found. This emphasizes the limitations of CCT in detecting this disorder. Biochemical and red blood cell immunological genetic linkage studies were done in 36 persons. No linkage was found with any of the markers. The natural history of this disorder, characterized by marked clinical and radiographic variation in site of lesion, and the timing and severity of intracranial hemorrhage, make it a useful model for investigating contributing factors and consequences of intracranial hemorrhage in general. For at-risk and affected patients early and sequential CCTs are necessary. Familial cavernous angioma should be included in the differential diagnosis of all young persons presenting with cerebrovascular impairment, seizures, intracranial calcifications or hemorrhage.

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Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Familial cavernous angiomas: Natural history and genetic study over a 5‐year period

et al. 1982

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“…Cavernous haemangiomas or cavernomas are regarded as rare (8,33,63,64). Dandy (12) collected 44 cavernomas from the literature and added five personal cases.…”

Section: Zusammenfassungmentioning

confidence: 99%

Cerebral Cavernous Haemangiomas or Cavernomas

Voigt¹,

Yaşargil²

1976

Minim Invasive Neurosurg

155

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Reviewing the literature and adding one unusual case the features of 164 cerebral cavernous haemangiomas are described with special reference to incidence, localization, diagnosis and clinical findings. Cavernomas may be found in every age group including the neonatal period. The sex incidence is equal. In 126 cases (76.8%) the cavernomas were of supratentorial, in 34 cases (20.7%) of infratentorial site, and in 4 more cases (2.5%) there was multiple occurence of supratentorial and posterior fossa cavernous haemangiomas. A specific clinical syndrome could not be defined: but the course is usually acute or subacute, and initial symptoms are commonly epileptic fits, acute headache and subarachnoid or intracerebral haemorrhage. Macroscopic calcifications of cerebral cavernomas were found only in 18 cases (11%). Cerebral angiography was done in 31 cases (18.9%). In 9 cases angiography was totally normal, and in 11 cases the cavernoma presented only as an avascular mass. In the remaining cases there was no conformity in the angiographic appearance of cerebral cavernous haemangiomas. Operative extirpation is the treatment of choice if a solitary lesion is favourably located. In addition to our patient there are now 21 cases (12.8%) in which cavernomas were treated successfully by operative extirpation.

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“…Cavernous haemangiomas in the cutis and subcuticular layers occur relatively frequently (7,20,29,31,32). However, those of the skull and soft-tissues of the scalp arc rare (5,23,36).…”

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confidence: 99%

Cavernous Angiomas of the Skull

Kirchhoff¹,

Hr²,

Al³

1978

Minim Invasive Neurosurg

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The authors present a series of 25 cases of haemangioma of the skull and review the literature. Frontal localization was the most frequent, contrary to the data in the literature which suggest predominance in the parietal region. The reported predominance of females has not been confirmed. In the present series the relation of males to females was 17:8. The radiological findings and treatment of haemangiomas are discussed. Direct puncture and injection of contrast medium is the best method of visualization of the tumour. Treatment should be surgical, consisting of total extirpation of the tumour with a margin of healthy tissue. Simple extirpation is indicated only when the soft tissues are involved and there is no bone lesion. Excision en bloc is the tehcnique of choice.

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Intracerebral cavernous hemangioma with angiographically demonstrated pathologic vasculature

Cited by 46 publications

References 13 publications

Familial cavernous angiomas: Natural history and genetic study over a 5‐year period

Familial cavernous angiomas: Natural history and genetic study over a 5‐year period

Cerebral Cavernous Haemangiomas or Cavernomas

Cavernous Angiomas of the Skull

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