Intracellular trafficking and dynamics of P bodies

Aizer, Adva; Shav‐Tal, Yaron

doi:10.4161/pri.2.4.7773

Cited by 33 publications

(29 citation statements)

References 37 publications

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“…21,22 AG nucleation relies on the expression of the active tyrosine kinase part of the ALK protein and is abolished when ALK + cells are treated with an ALK specific inhibitor. 24 Akin to PBs and with similar kinetics, 5 AGs move along microtubules where they frequently contact PBs ( fig. 1 and reviewed in ref.…”

Section: S Fraction From Alkmentioning

confidence: 90%

“…Photo-bleaching experiments confirmed that some components are indeed rapidly exchanged between RNA granules and the cytoplasm while others are almost static. [5][6][7] PBs, and to a lesser extent SGs, are highly dynamic entities that use the cytoskeleton to move, assemble and disassemble. 5,8 During their movements, PBs may come into close contact and frequently fuse with each other.…”

Section: Mammalian Pbs and Sgsmentioning

confidence: 99%

“…[5][6][7] PBs, and to a lesser extent SGs, are highly dynamic entities that use the cytoskeleton to move, assemble and disassemble. 5,8 During their movements, PBs may come into close contact and frequently fuse with each other. 5 Those interactions might favor exchange and incorporation of distinct proteins or messenger RiboNucleoProtein complexes (mRNPs) creating heterogeneous PBs.…”

Section: Mammalian Pbs and Sgsmentioning

confidence: 99%

“…5,8 During their movements, PBs may come into close contact and frequently fuse with each other. 5 Those interactions might favor exchange and incorporation of distinct proteins or messenger RiboNucleoProtein complexes (mRNPs) creating heterogeneous PBs. In stressed cells, PBs may also interact with SGs with which they share several proteins and the same species of reporter mRNA.…”

Section: Mammalian Pbs and Sgsmentioning

confidence: 99%

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Looking for the functions of RNA granules in ALK-transformed cells

et al. 2011

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Section: S Fraction From Alkmentioning

confidence: 90%

Section: Mammalian Pbs and Sgsmentioning

confidence: 99%

Section: Mammalian Pbs and Sgsmentioning

confidence: 99%

Section: Mammalian Pbs and Sgsmentioning

confidence: 99%

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Looking for the functions of RNA granules in ALK-transformed cells

et al. 2011

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“…Initially identified through the use of an autoimmune serum targeting a glycine-tryptophan-rich protein, GW182, these membranefree structures are also called GW bodies (Eystathioy et al 2002). They are anchored to microtubules and move around in the cytoplasm (Aizer and Shav-Tal 2008;Lindsay and McCaffrey 2011). mRNA decay intermediates are found in P-bodies, and inhibition of 59-to-39 mRNA decay increases the size of P-bodies (Sheth and Parker 2003), suggesting that mRNAs can be degraded in P-bodies.…”

Section: Introductionmentioning

confidence: 99%

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation

Zheng

Chen²,

Shyu³

2011

RNA

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The cellular factors involved in mRNA degradation and translation repression can aggregate into cytoplasmic domains known as GW bodies or mRNA processing bodies (P-bodies). However, current understanding of P-bodies, especially the regulatory aspect, remains relatively fragmentary. To provide a framework for studying the mechanisms and regulation of P-body formation, maintenance, and disassembly, we compiled a list of P-body proteins found in various species and further grouped both reported and predicted human P-body proteins according to their functions. By analyzing protein-protein interactions of human P-body components, we found that many P-body proteins form complex interaction networks with each other and with other cellular proteins that are not recognized as P-body components. The observation suggests that these other cellular proteins may play important roles in regulating P-body dynamics and functions. We further used siRNA-mediated gene knockdown and immunofluorescence microscopy to demonstrate the validity of our in silico analyses. Our combined approach identifies new P-body components and suggests that protein ubiquitination and protein phosphorylation involving 14-3-3 proteins may play critical roles for post-translational modifications of P-body components in regulating P-body dynamics. Our analyses provide not only a global view of human P-body components and their physical interactions but also a wealth of hypotheses to help guide future research on the regulation and function of human P-bodies.

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mRNPs meet stress granules

Sheinberger

Shav‐Tal

2017

FEBS Letters

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Edited by Wilhelm JustStress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA-binding proteins, and have been studied in connection to major cellular events such as protein synthesis as well as disease. Despite the well-known fact that stress granules encapsulate mRNPs (mRNA-protein complexes), much of the research has naturally focused on the protein components of stress granules. The specific details of mRNP entry into and exit from stress granules and the functional reasons for these dynamics are not fully understood. Here, we review studies that have concentrated on the aspects of mRNP accumulation in stress granules and produced quantitative data concerning mRNP/stress granule interactions.

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Intracellular trafficking and dynamics of P bodies

Cited by 33 publications

References 37 publications

Looking for the functions of RNA granules in ALK-transformed cells

Looking for the functions of RNA granules in ALK-transformed cells

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation

mRNPs meet stress granules

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