“…However, it is also possible that intracellular lysosomal cathepsins can generate cryptic fragments of collagen inside the cell (Ishida & Nagata, 2009;Wagenaar-Miller et al, 2007). Interestingly, using novel zebrafish models and electron microscopy ima- isms, which collectively contribute to degrading and eliminating misfolded molecules (Gotkin, Ripley, Lamande, Bateman, & Bienkowski, 2004;Ishida & Nagata, 2009;Lee & Ye, 2018;Ponpuak et al, 2015).…”