2002
DOI: 10.2337/diabetes.51.2007.s385
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Intracellular Targeting of Protein Kinases and Phosphatases

Abstract: Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger؊ mediated signaling events. Localization of the cAMPdependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of a… Show more

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Cited by 42 publications
(36 citation statements)
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“…To add to the complexity of this whole area of regulation, there is evidence that PDEs are also tethered in the AKAP/PKA complex (Dodge et al, 2001). Scott and colleagues outlined possible regulatory aspects of PKA observed in other cell types that have not yet been explored in the β cell (Alto et al, 2002).…”
Section: Involvement Of Iqgap1mentioning
confidence: 99%
“…To add to the complexity of this whole area of regulation, there is evidence that PDEs are also tethered in the AKAP/PKA complex (Dodge et al, 2001). Scott and colleagues outlined possible regulatory aspects of PKA observed in other cell types that have not yet been explored in the β cell (Alto et al, 2002).…”
Section: Involvement Of Iqgap1mentioning
confidence: 99%
“…In AKAP79, a homologous sequence occurs in residues 392-405. These sequences are amphipathic helices that provide a hydrophobic pocket for the binding of PKA R-subunit dimers [13,53]. The affinity of the R subunits for binding to these regions is in the nanomolar range: 0.5 nM for RI and 4.5 nM for RII [54].This sequence provides a basis for the Ht-31 blocking peptide (residues 493-515) [4], which has been shown to block the interaction of the β 2 AR with AKAP79 [47] and AKAP250 [19].…”
Section: Pka Ri/ii Binding Domainmentioning
confidence: 99%
“…Specificity of the phosphorylation/dephosphorylation event is in part achieved by selective employment of a protein kinase/phosphatase cascade and subcellular targeting (1,2). Both spatial and temporal specificity of signaling events is achieved by the compartmentalization of the signaling complexes through adaptor or anchoring proteins (1,2). Recent studies have highlighted novel aspects of integrating spatially and temporally the cAMP signaling cascades via a diverse family of protein kinase A anchoring proteins (AKAPs) 2 (3).…”
mentioning
confidence: 99%
“…Specificity of the phosphorylation/dephosphorylation event is in part achieved by selective employment of a protein kinase/phosphatase cascade and subcellular targeting (1,2). Both spatial and temporal specificity of signaling events is achieved by the compartmentalization of the signaling complexes through adaptor or anchoring proteins (1,2).…”
mentioning
confidence: 99%
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