Intracellular Signalling and Regulation of Gastric Acid Secretion

Hanson, Peter J.; Hatt, Jean F.

doi:10.1113/expphysiol.1989.sp003315

Cited by 14 publications

(4 citation statements)

References 93 publications

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“…The elevation of intracellular Ca 2ϩ manifested as an initial spike, representing Ca 2ϩ release from intracellular stores, followed by a lower-level Ca 2ϩ plateau caused by an inward Ca 2ϩ current (97). Although a concomitant rise of intracellular inositol trisposphate (IP 3 ) concentrations has been observed during carbachol stimulation (17), the role of PKC in this pathway is still controversial (2,7,12,50,161). Phosphorylation of the 28-kDa calcium-sensitive protein CSPP28 is reported to be a direct effect of cholinergic stimulation (107).…”

Section: Signalingmentioning

confidence: 99%

Revisiting the parietal cell

Kopic

Murek

Geibel

2010

American Journal of Physiology-Cell Physiology

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The parietal cell is responsible for secreting concentrated hydrochloric acid into the gastric lumen. To fulfill this task, it is equipped with a broad variety of functionally coupled apical and basolateral ion transport proteins. The concerted scientific effort over the last years by a variety of researchers has provided us with the molecular identity of many of these transport mechanisms, thereby contributing to the clarification of persistent controversies in the field. This article will briefly review the current model of parietal cell physiology and ion transport in particular and will update the existing models of apical and basolateral transport in the parietal cell.

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Section: Signalingmentioning

confidence: 99%

Revisiting the parietal cell

Kopic

Murek

Geibel

2010

American Journal of Physiology-Cell Physiology

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“…The increase in gastric acidity is considered an important contributing factor in the pathogenesis of gastric and duodenal ulcers and is often termed the 'aggressive factor' [36], The regulation of gastric acid secretions is complex and complicated; en dogenous gastrin, histamine, somatostatin and choliner gic mechanisms play major roles in controling gastric secretions [37], All these pathways converge on and mod ulate the activity of the proton pump of the parietal cells [38] . For acid secretion the expulsion of H+ across the api cal membrane is coupled with the movement of K+ into the cell [37], Furthermore basolatcral Na+-H+ exchange may also be a necessary accompaniment of acid secretion [39] Pretreatment with quinacrine significantly protected rats against indomethacin-induced gastric ulcers (table 2). Gastropathy associated with chronic use of NSAIDs is one of the major public health problems [66,67].…”

Section: Discussionmentioning

confidence: 99%

Effect of Quinacrine, a Phospholipase A<sub>2</sub> Inhibitor on Stress and Chemically Induced Gastroduodenal Ulcers

Moutaery

Tariq²

1997

Digestion

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Quinacrine, a phospholipase A₂ inhibitor, has been studied for its ability to inhibit gastric secretion and to protect the gastric and duodenal mucosa against chemically and stress-induced ulcers. Acid secretion studies were undertaken in pylorus-ligated rats with and without quinacrine treatment. Experimental gastric lesions were induced by water-immersion restraint stress, indomethacin and 80% ethanol in rats; whereas duodenal ulcers were produced by treatment of rats with cysteamine. The level of nonprotein sulfhydryl compounds and gastric wall mucus were also measured in the glandular stomach of the rats following ethanol-induced gastric lesions. The results of this study demonstrate that quinacrine produces a dose-dependent inhibition of gastric acid secretion in rats. Pretreatment with quinacrine significantly attenuated the formation of stress-, indomethacin- and ethanol-induced gastric lesions. Quinacrine also protected intestinal mucosa against cysteamine-induced duodenal ulcers. The antiulcer activity of quinacrine was associated with appreciable inhibition of ethanol-induced depletion of nonprotein sulfhydryls and gastric wall mucus. These findings point towards the mediation of sulfhydryls in quinacrine-induced gastrointestinal cytoprotection. In conclusion, this study demonstrates that quinacrine possesses significant antiulcer and cytoprotective activity against various experimentally induced gastroduodenal lesions. Although the mechanism of action of quinacrine requires further evaluation, the experimental observations derived from this study may have future clinical relevance and therefore deserve to be investigated thoroughly.

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“…For acid secretion the expulsion of H + across the apical membrane is coupled with the movement of K + into the cell (Hanson & Hatt, 1989). Phospholipase A2 inhibitors are known to modulate proton conductance across cell membranes (Evans & Surprenant, 1993).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

Mahesh¹,

Jeyachandran²,

Rao³

et al. 2012

Rev. bras. farmacogn.

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Abstract:In the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, signifi cantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed signifi cant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.

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Intracellular Signalling and Regulation of Gastric Acid Secretion

Cited by 14 publications

References 93 publications

Revisiting the parietal cell

Revisiting the parietal cell

Effect of Quinacrine, a Phospholipase A<sub>2</sub> Inhibitor on Stress and Chemically Induced Gastroduodenal Ulcers

Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

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