Intracellular records of carbachol-induced theta rhythm in hippocampal slices

Spike Frequency Adaptation Affects the Synchronization Properties of Networks of Cortical Oscillators

“…Experimental evidence suggests that cholinergic drugs induce synchronous theta rhythm and gamma rhythm oscillations in electroencepalogram (EEG) recordings from hippocampus (Konopacki, MacIver, Bland, & Roth, 1987;Bland, Colom, Konopacki, & Roth, 1988) and olfactory cortex (Biedenbach, 1966). In these experiments, the typical cholinergic effect is an increase in the number of fast gamma oscillations seen in spontaneous EEG activity.…”

MuSK Expressed in the Brain Mediates Cholinergic Responses, Synaptic Plasticity, and Memory Formation

“…Studies from several groups have shown that the cholinergic input to the hippocampus underlies physiological theta rhythm in vivo (for review, see Bland and Colom, 1993), which has been implicated in diverse behavioral and cognitive functions, including learning and memory (Winson, 1978;Buzsaki, 2002). Other studies have demonstrated that the cholinergic agonist carbachol produces a patterned oscillatory behavior in acute hippocampal slices that resembles theta rhythm (Bland et al, 1988;MacVicar and Tse, 1989;Williams and Kauer, 1997) and that such theta-like activity can enhance synaptic plasticity in a bidirectional manner Lisman, 1995, 1996). We therefore tested whether MuSK is involved in the modulation of patterned cholinergic activity in the hippocampus.…”

Computational model of carbachol‐induced delta, theta, and gamma oscillations in the hippocampus

“…Furthermore, recent experiments indicate that the intrinsic properties of the isolated CA3 region in the hippocampus contribute to theta rhythms observed in vivo (Kocsis et al, 1999). Muscarinic activation of the CA3 region, using the agonist carbachol, results in synchronous population activity in the delta (Boguszewicz et al, 1996;Fellous and Sejnowski, 2000), theta (Bland et al, 1988;Fellous and Sejnowski, 2000;Konopacki et al, 1987;MacVicar and Tse, 1989;Williams and Kauer, 1997), and gamma (Fellous and Sejnowski, 2000;Fisahn et al, 1998) bands. These intracellular studies have shown that cholinergically induced delta and theta (CCH-␦ and CCH-) oscillations depended on the pyramidal cell network of the CA3 region, but gamma (CCH-␥) also required an intact network of GABAergic interneurons.…”