Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of α-Hydroxyl Acids on Keratinocytes

Cao, Xu; Yang, Fan; Zheng, Jie; Wang, Kewei

doi:10.1074/jbc.m112.364869

Cited by 56 publications

(92 citation statements)

References 79 publications

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“…The low diversity of peripheral sensory transduction channels responsive to variations of pH, when compared to other stimuli, could explain the low response of crocodylian ISOs. Indeed, only a few members of the TRP family, including TRPV1 and TRPV3 , have been shown to respond to pH changes in mammalian cells [49,50]. We additionally observed that the stimulation of ISOs with the specific TRPV1-3 agonist 2-APB triggered a similar response time to acidification or alkalinization (Figure 5), suggesting that these transduction channels might also act as pH sensors in crocodylians.…”

Section: Resultsmentioning

confidence: 52%

“…In cell culture models, TRPV1 and the related receptor TRPV2, are activated by high temperatures (above 42°C and 52°C, respectively), whereas TRPV3 and TRPV4 are activated by lower temperatures (27°C to 34°C and 34°C to 39°C, respectively). In addition to warm temperature, TRPV1 and TRPV3 have been shown to respond to severe pH changes, while TRPV2 and TRPV4 are activated by cell swelling induced by hypotonic solutions [49,50,60]. Our study suggests that similar TRPV channels are used by crocodylian ISOs to detect different temperature and pH thresholds.…”

Section: Discussionmentioning

confidence: 72%

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Crocodylians evolved scattered multi-sensory micro-organs

Di‐Poï

Milinkovitch

2013

EvoDevo

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BackgroundDuring their evolution towards a complete life cycle on land, stem reptiles developed both an impermeable multi-layered keratinized epidermis and skin appendages (scales) providing mechanical, thermal, and chemical protection. Previous studies have demonstrated that, despite the presence of a particularly armored skin, crocodylians have exquisite mechanosensory abilities thanks to the presence of small integumentary sensory organs (ISOs) distributed on postcranial and/or cranial scales.ResultsHere, we analyze and compare the structure, innervation, embryonic morphogenesis and sensory functions of postcranial, cranial, and lingual sensory organs of the Nile crocodile (Crocodylus niloticus) and the spectacled caiman (Caiman crocodilus). Our molecular analyses indicate that sensory neurons of crocodylian ISOs express a large repertoire of transduction channels involved in mechano-, thermo-, and chemosensory functions, and our electrophysiological analyses confirm that each ISO exhibits a combined sensitivity to mechanical, thermal and pH stimuli (but not hyper-osmotic salinity), making them remarkable multi-sensorial micro-organs with no equivalent in the sensory systems of other vertebrate lineages. We also show that ISOs all exhibit similar morphologies and modes of development, despite forming at different stages of scale morphogenesis across the body.ConclusionsThe ancestral vertebrate diffused sensory system of the skin was transformed in the crocodylian lineages into an array of discrete multi-sensory micro-organs innervated by multiple pools of sensory neurons. This discretization of skin sensory expression sites is unique among vertebrates and allowed crocodylians to develop a highly-armored, but very sensitive, skin.

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Section: Resultsmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 72%

Crocodylians evolved scattered multi-sensory micro-organs

Di‐Poï

Milinkovitch

2013

EvoDevo

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“…Low cellular O 2 reduces the activity of FIH, releasing the inhibition and increasing TRPV3 current density upon activation 109 . TRPV3 channels are also activated by intracellular protons H + 110 , which could contribute to activation of TRPV3 under hypoxic conditions channels in vivo . The effects of hypoxia on TRPV3 activity in the endothelium have not been reported.…”

Section: S-nytrosylation Of Trpv3 Channelsmentioning

confidence: 99%

Redox regulation of transient receptor potential channels in the endothelium

Pires

Earley

2017

Microcirculation

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are important mediators of signaling pathways in the endothelium. Specific members of the transient receptor potential (TRP) superfamily of cation channels act as important Ca2+ influx pathways in endothelial cells, and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review we highlight the recent literature describing in redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.

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“…Furthermore, farnesyl pyrophosphate and isopentenyl pyrophosphate, intermediates of the melanovate pathway, are activator and inhibitor respectively, suggesting a fine-tuning of TRPV3 function (Bang et al 2010;. Alfa-hydroxy acids are proton donors commonly used in cosmetics to produce skin exfoliation mediated by TRPV3 activation (Cao et al 2012). The pharmacology of the TRPV family is far from simple, and TRPV3 is not an exception (Table 2.1 and Fig.…”

Section: Trpv3mentioning

confidence: 97%

Pharmacology of TRP Channels

Fernández-Carvajal

Fernández‐Ballester

González‐Muñiz

et al. 2015

TRP Channels in Sensory Transduction

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This themed issue of the British Journal of Pharmacology contains review and research articles on recent advances in transient receptor potential (TRP) channel pharmacology. The review articles, written by a panel of distinguished experts, address the rapid progress in TRP channel research in fields as diverse as oncology, urology, dermatology, migraine, inflammation and pain. These reviews are complemented by original research reports focusing, among others, on the emerging roles of TRPV1 in osteoporosis and cystitis and on evodiamine as a lead structure for the development of potent TRPV1 agonists/desensitizers. Other papers highlight the differences in TRPV3 pharmacology between recombinant and native systems, the mechanisms of TRPM3 activation/inhibition and TRPP2 as a target of naringenin, a dietary flavonoid with anticancer actions. New therapeutic opportunities in pain may arise from the strategy to combine TRP channel and cell membrane impermeant sodium channel blockers to inhibit sensory nerve activity. LINKED ARTICLES This article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx. Abbreviations CXCR2, chemokine CC motif receptor 2; TRP, transient receptor potential; TRPA, TRP channel subfamily A; TRPC, TRP channel subfamily C; TRPM, TRP channel subfamily M; TRPP, TRP channel polycystin subfamily; TRPV, TRP channel subfamily V The transient receptor potential (TRP) cation channel super-family is classified into six related subfamilies: the TRP channel subfamily C (canonical, TRPC), the TRP channel subfamily V (vanilloid, TRPV), the TRP channel subfamily M (melastatin, TRPM), the TRP channel subfamily A (ankyrin, TRPA), the TRP channel polycystin subfamily (TRPP) and the TRP channel mucolipin subfamily (Moran et al., 2011; Fernandes et al., 2012). The TRPs are, in general, non-selective cation channels that open in response to changes in temperature, ligand binding and other alterations of the channel protein, but are only weakly sensitive to depolariza-tion (Vay et al., 2012). Animal and human genetic studies have shown that alterations in TRP channel functions-in a pathological context known as TRP channelopathies-are causative for a variety of diseases, such as inherited pain syndrome, multiple kidney diseases and skeletal muscle disorders (Moran et al., 2011). In this themed issue, we have brought together a number of informative reviews depicting and discussing some of the basic and clinical concepts that emerge from the current TRP channel research. Since the identification of the first mam-malian TRP channels in the 1990s, these entities have been addressed as potential targets for drugs, and Kaneko and Szallasi (2014) review the current status of TRP channels from a clinical perspective. Despite accumulating evidence to implicate a number of TRP channels in a wide range of diseases , only 4 of the 28 mammalian TRP channel subunits, namely TRPM8, TRPA1, TRPV1 and TRPV3, have been exploited so far to reach the clinical stage ...

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Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of α-Hydroxyl Acids on Keratinocytes

Cited by 56 publications

References 79 publications

Crocodylians evolved scattered multi-sensory micro-organs

Crocodylians evolved scattered multi-sensory micro-organs

Redox regulation of transient receptor potential channels in the endothelium

Pharmacology of TRP Channels

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