Intracellular Progesterone Receptor Mediates the Increase in Glioblastoma Growth Induced by Progesterone in the Rat Brain

Germán-Castelán, Liliana; Manjarrez-Marmolejo, Joaquín; González-Arenas, Aliesha

doi:10.1016/j.arcmed.2016.10.002

Cited by 19 publications

(12 citation statements)

References 35 publications

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“…A similar study was performed on rat xenografted with U87 cells into the cerebral cortex and described an opposite effect for lower dose of progesterone (4mg/kg). The effect of progesterone, mediated through PR, would be responsible for an increase in tumor area and infiltration length [80]. In an in vivo model, U373 cells were implanted in the motor cortex of rat exposed to 1mg of progesterone.…”

Section: Exogenous Progesterone Exposure: a Dose-dependent Modulationmentioning

confidence: 99%

Astrocytoma: A Hormone-Sensitive Tumor?

Hirtz

Rech

Dubois-Pot-Schneider

et al. 2020

IJMS

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Astrocytomas and, in particular, their most severe form, glioblastoma, are the most aggressive primary brain tumors and those with the poorest vital prognosis. Standard treatment only slightly improves patient survival. Therefore, new therapies are needed. Very few risk factors have been clearly identified but many epidemiological studies have reported a higher incidence in men than women with a sex ratio of 1:4. Based on these observations, it has been proposed that the neurosteroids and especially the estrogens found in higher concentrations in women’s brains could, in part, explain this difference. Estrogens can bind to nuclear or membrane receptors and potentially stimulate many different interconnected signaling pathways. The study of these receptors is even more complex since many isoforms are produced from each estrogen receptor encoding gene through alternative promoter usage or splicing, with each of them potentially having a specific role in the cell. The purpose of this review is to discuss recent data supporting the involvement of steroids during gliomagenesis and to focus on the potential neuroprotective role as well as the mechanisms of action of estrogens in gliomas.

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Section: Exogenous Progesterone Exposure: a Dose-dependent Modulationmentioning

confidence: 99%

Astrocytoma: A Hormone-Sensitive Tumor?

Hirtz

Rech

Dubois-Pot-Schneider

et al. 2020

IJMS

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“…Similarly, progesterone and allopregnanolone increase cell proliferation, migration and invasion of GBM cells in vitro (González-Agüero et al, 2007; Piña-Medina et al, 2016; Zamora-Sánchez et al, 2017). Moreover, progesterone also promotes GBM tumor growth and infiltration in rats’ cerebral cortex in a xenograft model (Germán-Castelán et al, 2014, 2016), effects which are mainly mediated by the PR, given that they are partially blocked in GBM cells following the administration of mifepristone (González-Agüero et al, 2007; Germán-Castelán et al, 2014; Piña-Medina et al, 2016). This partial inhibition indicated the implication of the non-classical progesterone mechanisms of action.…”

Section: Progesterone Actions During Cns Developmentmentioning

confidence: 99%

Progesterone Actions During Central Nervous System Development

González-Orozco

Camacho‐Arroyo

2019

Front. Neurosci.

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Although progesterone is a steroid hormone mainly associated with female reproductive functions, such as uterine receptivity and maintenance of pregnancy, accumulating data have shown its physiological actions to extend to several non-reproductive functions in the central nervous system (CNS) both in males and females. In fact, progesterone is de novo synthesized in specific brain regions by neurons and glial cells and is involved in the regulation of various molecular and cellular processes underlying myelination, neuroprotection, neuromodulation, learning and memory, and mood. Furthermore, progesterone has been reported to be implicated in critical developmental events, such as cell differentiation and neural circuits formation. This view is supported by the increase in progesterone synthesis observed during pregnancy in both the placenta and the fetal brain. In the present review, we will focus on progesterone actions during CNS development.

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“…Its function in breast cancer development, however, remains unestablished, although the theory of an individual contribution by the PGR isoforms to malignant development is receiving attention 12 , 13 . Indeed, the presence of the PGRs has been confirmed in several other malignancies including endometrial cancer 14 , PCa 15 – 20 , lung cancer 21 and astrocytomas 22 , although not necessarily separating between the two receptor isoforms. Altogether, this indicates the PGRs’ involvement in numerous biological processes throughout the human body and a broad spectrum of tissue specific receptor functions.…”

Section: Introductionmentioning

confidence: 96%

Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression

Grindstad

Richardsen

Andersen

et al. 2018

Sci Rep

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The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms (PGRA, PGRB) in PCa tissue and their association with clinical endpoints. This was conducted retrospectively by collecting radical prostatectomy specimens from 535 patients. Tissue was analyzed using tissue microarray, where representative tumor areas were carefully selected. Protein expression was evaluated through immunohistochemistry, in stromal and epithelial tissue. Associations between receptor expression and clinical data were considered using statistical survival analyses. Herein, we discovered a solely stromal PGRA- and a stromal and epithelial PGRB expression. Further, a high PGRB expression in tumor tissue was associated with an unfavorable prognosis in both univariate and multivariate analyses: Biochemical failure (HR: 2.0, 95% CI: 1.45–2.76, p < 0.001) and clinical failure (HR: 2.5, 95% CI: 1.29–4.85, p = 0.006). These findings are in agreement with our previous investigation on pan-PGR, indicating that the observed negative effect of PGR is represented by PGRB.

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Intracellular Progesterone Receptor Mediates the Increase in Glioblastoma Growth Induced by Progesterone in the Rat Brain

Cited by 19 publications

References 35 publications

Astrocytoma: A Hormone-Sensitive Tumor?

Astrocytoma: A Hormone-Sensitive Tumor?

Progesterone Actions During Central Nervous System Development

Progesterone Receptors in Prostate Cancer: Progesterone receptor B is the isoform associated with disease progression

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