Intracellular Potential in Normal and Leukemic Lymphocytes

Malofiejew, M; Kostrzewska, Anna; Kowal, E

doi:10.1159/000208174

Cited by 2 publications

(1 citation statement)

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“…of Rad. Onc., UTMB., Galveston TX 77550, U.S.A. and the intracellular potential of a variety of non-excitable cells (Beckman et al, 1970;Choudhury and Chou, 1973;Giberman et al, 1974;Lassen and Sten-Knudsen, 1968;Malofiejew et al, 1975).…”

Section: Introduetlonmentioning

confidence: 99%

Variations in the intracellular potentials of sub-populations of human peripheral blood mononuclear cells

Niemtzow

Gauci

Serrou

1978

Cancer Immunol Immunother

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Summary. The intracellular potential of human peripheral blood lymphoeytes and monocytes was measured with a modified neurophysiologieal system and was found to vary between -20 mV and +20 mV. By depleting the total mononuelear fraetion of monocytes and Blymphoeytes, and by using various separation procedures to derive monoeyte, B-lymphocyte-, T-lymphocyte-, and null cell-enriched populations, it was possible to show that monoeytes and the majority of the B-lymphocytes had positive intraeellular potentials, whereas Tlymphoeytes and null cells had negative intraeellular potentials. Various factors, which include in vitro cultur

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Section: Introduetlonmentioning

confidence: 99%

Variations in the intracellular potentials of sub-populations of human peripheral blood mononuclear cells

Niemtzow

Gauci

Serrou

1978

Cancer Immunol Immunother

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Voltage-Gated Proton Channels and Other Proton Transfer Pathways

DeCoursey

2003

Physiological Reviews

681

913

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Proton channels exist in a wide variety of membrane proteins where they transport protons rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules present in the protein, but its function is regulated by titratable groups on critical amino acid residues in the pathway. All proton channels conduct protons by a hydrogen-bonded chain mechanism in which the proton hops from one water or titratable group to the next. Voltage-gated proton channels represent a specific subset of proton channels that have voltage- and time-dependent gating like other ion channels. However, they differ from most ion channels in their extraordinarily high selectivity, tiny conductance, strong temperature and deuterium isotope effects on conductance and gating kinetics, and insensitivity to block by steric occlusion. Gating of H(+) channels is regulated tightly by pH and voltage, ensuring that they open only when the electrochemical gradient is outward. Thus they function to extrude acid from cells. H(+) channels are expressed in many cells. During the respiratory burst in phagocytes, H(+) current compensates for electron extrusion by NADPH oxidase. Most evidence indicates that the H(+) channel is not part of the NADPH oxidase complex, but rather is a distinct and as yet unidentified molecule.

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Intracellular Potential in Normal and Leukemic Lymphocytes

Cited by 2 publications

References 0 publications

Variations in the intracellular potentials of sub-populations of human peripheral blood mononuclear cells

Variations in the intracellular potentials of sub-populations of human peripheral blood mononuclear cells

Voltage-Gated Proton Channels and Other Proton Transfer Pathways

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