Intracellular plasma proteins in human fetal choroid plexus during development I. Developmental stages in relation to the number of epithelial cells which contain albumin in telencephalic, diencephalic and myelencephalic choroid plexus

Jacobsen, Marianne; Clausen, Per P.; Jacobsen, Grete Krag; Saunders, NR; Møllgård, Kjeld

doi:10.1016/0165-3806(82)90024-4

Cited by 22 publications

(16 citation statements)

References 7 publications

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“…11. Immunocytochemical evidence indicates that the route of transfer is an intracellular one via the choroid plexus epithelial cells; cell counts of different choroid plexuses for different plasma proteins suggest that transport occurs to a different extent in different choroid plexuses (lateral ventricular, 3rd ventricular or 4th ventricular) for different proteins (JACOBSEN et al 1982a(JACOBSEN et al ,b, 1983M0LLGARD et al 1987b;. Different proteins of rather similar molecular size have different steady state CSF plasma ratios early in brain development (see Fig.…”

Section: Proteins In Csf In the Fetus And Neonatementioning

confidence: 93%

Ontogenetic Development of Brain Barrier Mechanisms

Saunders¹

1992

Physiology and Pharmacology of the Blood-Brain Barrier

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Section: Proteins In Csf In the Fetus And Neonatementioning

confidence: 93%

Ontogenetic Development of Brain Barrier Mechanisms

Saunders¹

1992

Physiology and Pharmacology of the Blood-Brain Barrier

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“…6 th week: Early neurogenesis (Bystron et al 2008) and formation of radial glial cells (RGCs) (Howard et al 2008), formation of the preplate (PP) (Bystron et al 2008) and hippocampal thickening (Humphrey 1966). 7 th week: The choroid plexus of the lateral ventricles emerges (Jacobsen et al 1982). Reelin-producing CajalRetzius cells (CRCs) (Abraham et al 2004) and the subventricular zone (SVZ) appear (Møllgård and Jacobsen 1984;Bystron et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

Bjørnbak

Brøchner

Larsen

et al. 2014

J Histochem Cytochem.

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SummaryYKL-40, a glycoprotein involved in cell differentiation, has been associated with neurodevelopmental disorders, angiogenesis, neuroinflammation and glioblastomas. We evaluated YKL-40 protein distribution in the early human forebrain using double-labeling immunofluorescence and immunohistochemistry. Immunoreactivity was detected in neuroepithelial cells, radial glial end feet, leptomeningeal cells and choroid plexus epithelial cells. The subpial marginal zone was YKL-40-positive, particularly in the hippocampus, from an early beginning stage in its development. Blood vessels in the intermediate and subventricular zones showed specific YKL-40 reactivity confined to pericytes. Furthermore, a population of YKL-40-positive, small, rounded cells was identified in the ventricular and subventricular zones. Real-time quantitative RT-PCR analysis showed strong YKL-40 mRNA expression in the leptomeninges and the choroid plexuses, and weaker expression in the telencephalic wall. Immunohistochemistry revealed a differential distribution of YKL-40 across the zones of the developing telencephalic wall. We show that YKL-40 is associated with sites of the brain barrier systems and propose that it is involved in controlling local angiogenesis and access of peripheral cells to the forebrain via secretion from leptomeningeal cells, choroid plexus epithelium and pericytes. Furthermore, we suggest that the small, rounded, YKL-40-positive cells represent a subpopulation of astroglial progenitors, and that YKL-40 could be involved in the differentiation of a particular astrocytic lineage. (J Histochem Cytochem 62:369-388, 2014)

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“…Some studies based on this material have been published previously (e.g. Jacobsen et al 1982;Møllgård and Schumacher 1993).…”

Section: Methodsmentioning

confidence: 99%

Aquaporin-1 in the choroid plexuses of developing mammalian brain

Johansson

Dziegielewska

et al. 2005

Cell Tissue Res

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The normal brain develops within a well-controlled stable internal "milieu" protected by specialised mechanisms referred to collectively as blood-brain barriers. A fundamental feature of this environment is the control of water flow in and out of the developing brain. Because of limited vascularisation of the immature brain, choroid plexuses, via the cerebrospinal fluid, have been proposed as the main route of fluid exchange between the blood and brain interfaces. We describe the temporal expression and appearance of aquaporin-1 (AQP1) which is important for water transfer across adult choroid plexuses. AQP1 expression was studied in rat embryos using real time reverse transcription/polymerase chain reaction. mRNA for AQP1 was present in rat brain at embryonic day 12 (E12) one day before the protein was detectable in the fourth ventricular choroid plexus (the first plexus to appear); its relative levels increased at E13-E14 when more AQP1-immunoreactive cells appeared in all plexuses. The presence of AQP1 was determined immunocytochemically in five different mammalian species (rat, mouse, human, sheep and opossum) in all four choroid plexuses from their earliest appearance. In all five species studied, the appearance of AQP1 immunoreactivity followed the same developmental sequence: the fourth, lateral and, finally, third ventricular choroid plexus. The stage of choroid plexus development when AQP1 was first detected in all five species and in all four choroid plexuses corresponded to the transition between Stages I and II. The cellular localisation of AQP1 in all choroid plexuses, as soon as it was detectable, had the characteristic apical membrane distribution previously described in the adult; a basolateral membrane localisation was also observed.

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Intracellular plasma proteins in human fetal choroid plexus during development I. Developmental stages in relation to the number of epithelial cells which contain albumin in telencephalic, diencephalic and myelencephalic choroid plexus

Cited by 22 publications

References 7 publications

Ontogenetic Development of Brain Barrier Mechanisms

Ontogenetic Development of Brain Barrier Mechanisms

Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

Aquaporin-1 in the choroid plexuses of developing mammalian brain

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