Comprehensive Physiology 1997
DOI: 10.1002/cphy.cp140109
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Intracellular pH

Abstract: The sections in this article are: Techniques pH‐Sensitive Microelectrodes pH‐Sensitive Fluorescent Indicators Nuclear Magnetic Resonance Spectroscopy Some Observations on Intracellular pH Transients Mechanisms of pH Regulation Physicochemical Buffers … Show more

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Cited by 17 publications
(22 citation statements)
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“…For instance, central chemoreceptors, in response to an appropriate stimulus (i.e., during an acid/base disturbance), should produce a large signal (i.e., a large change in pH i ), and this signal should be maintained for the entire duration of the stimulus. This is in contrast to nonchemoreceptors, which typically maintain a more constant pH i in the face of acid/base disturbances due to membranebound pH-regulating transporters (19). The following characteristics would allow central chemoreceptors to function in this manner: 1) a low ␤ int to maximize the change in pH i during acid/base disturbances, 2) the ability of pH i to closely track pH o , and 3) the lack of and/or inhibition of pH i -regulating mechanisms during acid/base disturbances.…”
Section: Discussionmentioning
confidence: 97%
“…For instance, central chemoreceptors, in response to an appropriate stimulus (i.e., during an acid/base disturbance), should produce a large signal (i.e., a large change in pH i ), and this signal should be maintained for the entire duration of the stimulus. This is in contrast to nonchemoreceptors, which typically maintain a more constant pH i in the face of acid/base disturbances due to membranebound pH-regulating transporters (19). The following characteristics would allow central chemoreceptors to function in this manner: 1) a low ␤ int to maximize the change in pH i during acid/base disturbances, 2) the ability of pH i to closely track pH o , and 3) the lack of and/or inhibition of pH i -regulating mechanisms during acid/base disturbances.…”
Section: Discussionmentioning
confidence: 97%
“…Only a few of these have been conducted in the presence of sustained and elevated CO 2 ; however, other studies using metabolic acid-base challenges are informative about the relationship between pH i and pH e . The general pattern shown in these studies is that (1) reducing pH e causes pH i to be reduced and (2) complete recovery of pH i does not occur until the starting pH e is re-established (Occhipinti and Boron, 2015;Putnam and Roos, 1997;Vaughan-Jones et al, 2009 ] to reduce pH e , the pH i of all cell types was reduced and only fully recovered following the return of pH e to control values (Salameh et al, 2014). Generally, in vitro studies indicate that acute changes in external or environmental pH will rapidly affect pH i .…”
Section: In Vitro Studiesmentioning
confidence: 89%
“…It is well known that absolute physiological pH values differ between species and between body compartments within species, and are affected by temperature (Rahn, 1974); however, within a given system, pH values are regulated within a relatively narrow range (Cameron, 1989;Heisler, 1984). Deviations from normal physiological pH values can affect molecular charge, altering the structure and function of proteins, lipids, carbohydrates and nucleic acids, and, ultimately, reducing whole-animal performance (Occhipinti and Boron, 2015;Putnam and Roos, 1997). The degree to which a pH change affects function depends on the system in question.…”
Section: Introductionmentioning
confidence: 99%
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“…For most fishes, short-term exposure to a P w co 2 of more than 2 kPa results in uncompensated acidosis (see Brauner and Baker 2009) that can be lethal, although the exact mechanism(s) of CO 2 toxicity are unknown (Putnam and Roos 1997). In contrast, white sturgeon Acipenser transmontanus are remarkably tolerant of elevated CO 2 and the associated blood acidosis, exhibiting morbidity only when exposed to ≥8-kPa P w co 2 (D. W. Baker and C. J.…”
Section: Introductionmentioning
confidence: 99%