Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons

Erdélyi, L.; Ilyin, Victor I.; Lozovaya, N A; Vulfius, Catherine A.

doi:10.1016/0304-3940(90)90126-t

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…32 Moreover, it has been shown that intracellular Mg 2+ decreases the blocking efficiency of extracellularly applied catechol in isolated neurons, whereas catechol antagonizes the Mg 2+induced shis of the voltage-dependence of activation and inactivation. 33 Also, it was found that the complex between 3-hydroxy-avone and Mg II is formed in the excited state both from the normal and tautomer forms of the avonol, the latter way being more favourable. 34 Finally, the formation of a complex between Mg II and 5-hydroxy-avone was recently highlighted by various spectroscopic techniques.…”

Section: Introductionmentioning

confidence: 99%

Elucidation of complexation multi-equilibrium with Mg^II and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Moncomble

Cornard

2014

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Elucidation of complexation multi-equilibrium with Mg^II and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Moncomble

Cornard

2014

RSC Adv.

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Zinc modulates a-type potassium currents and neuronal excitability in snail neurons

Erdélyi¹

1994

Cell Mol Neurobiol

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1. Zinc-induced actions were studied on the A-current and neuronal activity in identified and unidentified nerve cells of the snail, Helix pomatia, L., under voltage and current clamp conditions. 2. Extracellularly applied Zn2+ attenuated the peak amplitude of the A-current in a potential- and dose-dependent way (Ki = 1.8 mM at -30 mV, nH = 0.6). 3. Attenuation of the A-currents was initiated as Zn2+ shifted the potential dependence of both activation and inactivation of the currents toward more positive potential values. 4. Zinc concomitantly prolonged the time to peak and the decay time constant of the A-currents (Kd = 1.7 mM, nH = 1.4) as well. 5. Zn2+ decreased the resting membrane potential and the spike amplitude and increased the action potential duration and the input resistance of the cells in current clamp experiments. 6. A complex action of zinc increased the neuronal excitability, indicating spontaneous and synaptically evoked spike discharges. 7. Common and specific zinc binding sites are supposed on vertebrate and invertebrate A-type potassium channel proteins, where binding Zn2+ can modulate the gating properties and kinetics of the fast outward potassium currents.

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Intracellular ATP modifies the voltage dependence of the fast transient outward K+ current in Lymnaea stagnalis neurones.

Lozovaya¹,

Vulfius²,

Ilyin³

et al. 1993

The Journal of Physiology

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5. Wrhen a mixture of glycolytic substrates was applied after arsenate wash-out the activation and inactivation curves shifted towards positive voltages. A substrate of oxidative phosphorylation was ineffective in the same conditions. 6. Non-hydrolysable analogues of ATP, adenosine-5'-0-y-thiotriphosphate and adenylyl imidodiphosphate, did not mimic the ATP action. This means that the ATP effect is mediated by some enzymatic process(es).7. Elevation of total cytosolic Ca21 concentration as well as intracellular application of agents increasing intracellular free Ca2' reduced A-current amplitude but failed to alter its voltage dependence. Therefore, ATP action cannot be related to activation of Ca21 transport.8. Treatment of the neurones with alkaline phosphatase evoked a shift of the inactivation voltage dependence towards hyperpolarizing potentials and increased the A-current amplitudes at all test voltages.9. The data indicate that a change in intracellular ATP concentration modulates the A-current voltage dependence. The effect of ATP is probably the result of phosphorylation of a channel protein or some associated proteins, but lowering of free Mg2+ concentration cannot be excluded. The possible physiological significance of the phenomenon is discussed.

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Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons

Cited by 3 publications

References 13 publications

Elucidation of complexation multi-equilibrium with Mg^II and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Elucidation of complexation multi-equilibrium with Mg^II and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Zinc modulates a-type potassium currents and neuronal excitability in snail neurons

Intracellular ATP modifies the voltage dependence of the fast transient outward K+ current in Lymnaea stagnalis neurones.

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Intracellular Mg2+ modulates the A-current and its blockage by catechol in isolated Lymnaea neurons

Cited by 3 publications

References 13 publications

Elucidation of complexation multi-equilibrium with MgII and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Elucidation of complexation multi-equilibrium with MgII and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Zinc modulates a-type potassium currents and neuronal excitability in snail neurons

Intracellular ATP modifies the voltage dependence of the fast transient outward K+ current in Lymnaea stagnalis neurones.

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Elucidation of complexation multi-equilibrium with Mg^II and a multisite ligand. A combined electronic spectroscopies and DFT investigation

Elucidation of complexation multi-equilibrium with Mg^II and a multisite ligand. A combined electronic spectroscopies and DFT investigation