“…In prokaryotes, the ~200 kDa Mg 2+ -dependent channel CorA is the key pathway for electrophoretic Mg 2+ uptake (Dalmas et al, 2014b; Hmiel et al, 1986; Maguire, 2006). CorA can functionally complement the eukaryotic mitochondrial Mrs2 channel (Kolisek et al, 2003), which is essential for normal mitochondrial activity (Weghuber et al, 2006), and whose abnormal expression has been associated with diseases ranging from cancer to demyelination of neuronal tissue (Kuramoto et al, 2011; Leanza et al, 2013). Recent experimental evidence suggests that Mg 2+ homeostasis through CorA takes place via a negative feedback loop, where Mg 2+ binding at the inter-subunit interfaces leads to channel closure, whereas low Mg 2+ concentrations tend to promote the transition to the open, conductive state (Dalmas et al, 2014b; Pfoh et al, 2012).…”