Intracellular Flux Prediction of Recombinant Escherichia coli Producing Gamma-Aminobutyric Acid
Sung Han Bae,
Myung Sub Sim,
Ki Jun Jeong
et al.
Abstract:Genome-scale metabolic model (GEM) can be used to simulate cellular metabolic phenotypes under various environmental or genetic conditions. This study utilized the GEM to observe the internal metabolic fluxes of recombinant
Escherichia coli
producing gamma-aminobutyric acid (GABA). Recombinant
E. coli
was cultivated in a fermenter under three conditions: pH 7, pH 5, and additional succinic acids. External fluxes were calculated from cultivation results, and interna… Show more
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