Intracellular delivery of virus-like particles using a sheddable linker

Abstract

Intracellular targeting is essential for the efficiently delivering of drugs and nanotherapeutics. Cytosolic transport of nanomaterials is often necessary for therapeutic delivery into cells but remains a challenge owing to...

TEMPO-conjugated tobacco mosaic virus as a magnetic resonance imaging contrast agent for detection of superoxide production in the inflamed liver

“…The development of “smart” contrast agents for MRI has been an ongoing area of active research for several decades. 13–24 Recent advances, for instance, have shown the ability to report concentrations of metals like Ca 2+ and Zn 2+ in deep tissue. 25,26 These probes are particularly valuable as they provide a minimally invasive approach to real-time analyses of metabolic processes within the body.…”