Intracellular Delivery of Quantum Dots Tagged Antisense Oligodeoxynucleotides by Functionalized Multiwalled Carbon Nanotubes

Jia, Nengqin; Lian, Qiong; Shen, Hebei; Wang, Chen; Li, Xingyu; Yang, Zhong‐Nan

doi:10.1021/nl071114c

Cited by 148 publications

(83 citation statements)

References 40 publications

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“…93,94 Jia et al 93 studied double functionalization of an MWCNT delivery system containing ASODNs as a therapeutic gene and semiconductor quantum dots (CdTe) as fluorescent labeling probes (Figure 3). The MWCNT-PEI-ASODNs-CdTe composites showed an ODN delivery efficiency of 95% in human cervical cancer (HeLa) cells and induced much higher cellular apoptosis than PEI-ASODNs or ASODNs alone.…”

Section: Cnts As Odn Carriersmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

206

102

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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Section: Cnts As Odn Carriersmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

206

102

View full text Add to dashboard Cite

show abstract

“…Pantarotto et al explored the delivery of bioactive peptides of K(FITC)QRMHLRQYELLC into 3T3 cells [12], methotrexate into Jurkat cells [13] and plasmid DNA into HeLa cells [14], using f-CNTs as non-targeted drug carriers. Additionally, f-CNTs have been applied as the non-targeted drug carriers to transport platinum(IV) [15], oligodeoxynucleotides [16] and boron [17] into cancer cells. Although great improvements have been made to the application of f-CNTs as drug carriers, there are two major obstacles blocking further use of the f-CNTs in cancer chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Zhao

et al. 2011

Carbon

134

126

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“…For instance, the high surface area along with the tunable surface chemistry enables the physical adsorption or covalent conjugation of a variety of therapeutic molecules, such as drugs, peptides and growth factors [2][3][4][5]. Additionally, NDs' surface can be modified with targeting biological signals to achieve a selective cellular internalization of chemotherapeutic agents as well as genetic materials.…”

mentioning

confidence: 99%

Adoption of nanodiamonds as biomedical materials for bone repair

et al. 2017

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Keywords: gene/drug delivery • nanodiamonds • therapeutics Nanodiamonds (NDs) are an emerging class of biologically compatible carbon-based nanomaterials that possess a set of unique properties essential for the design of innovative therapies in the fields of drug delivery, tissue engineering and bioimaging [1]. For instance, the high surface area along with the tunable surface chemistry enables the physical adsorption or covalent conjugation of a variety of therapeutic molecules, such as drugs, peptides and growth factors [2][3][4][5]. Additionally, NDs' surface can be modified with targeting biological signals to achieve a selective cellular internalization of chemotherapeutic agents as well as genetic materials. Aside from their role as carriers in drug and gene delivery, NDs have been widely explored as nanofillers to improve the physical and mechanical properties of both natural and synthetic scaffolds [6,7]. Specifically, NDs have found application in the field of bone tissue engineering as reinforcing nanomaterial to design nanocomposite systems necessary to promote bone regeneration. This editorial emphasizes on the current state-of-the-art research using NDs in the field of bone repair, with a focus on the recent breakthroughs such as precise immobilization of growth factors and peptides. Biomolecule immobilization via surface functionalization of NDsNDs are carbon-based nanomaterials, which possess a set of unique properties that enables their use in a variety of applications including drug delivery, tissue engineering and bioimaging. This advantage has encouraged scientists to investigate NDs for a broad range of applications [8] in regenerative medicine with a primary focus on bone tissue engineering. NDs possess versatile surface functionalities and they can be loaded with virtually any type of biomolecule, thereby enabling their use as delivery vehicles in bone-healing applications [9]. The presence of surface functional groups can efficiently control the interfacial reactions between the nanoparticle and the active biomolecule, eventually maximizing the therapeutic efficiency of the delivered biomaterial. The initial functional groups present on the surface of NDs, following the formation of the nanoparticle, vary according to the selected synthesis and purification methods. For example, hydrogen-assisted chemical vapor deposition generates NDs bearing hydrogen-terminated surfaces. On the other hand, methods, such as detonation synthesis, introduce a highly diverse surface chemistry, with functional groups such as hydroxyl, carbonyl, ether and carboxyl groups. It is essential to maintain a similar functionality throughout the entire surface to enable further surface reactions. Thus, chemical treatment of the NDs is often required to create homogenized reactive surfaces. Among the possible alternatives, carboxylation, hydroxylation or hydrogenation are the commonly investigated routes to generate -COOH and -OH groups on the surface. Due to the presence of these diverse functionalities on the surfac...

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Intracellular Delivery of Quantum Dots Tagged Antisense Oligodeoxynucleotides by Functionalized Multiwalled Carbon Nanotubes

Cited by 148 publications

References 40 publications

Carbon nanotubes as cancer therapeutic carriers and mediators

Carbon nanotubes as cancer therapeutic carriers and mediators

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Adoption of nanodiamonds as biomedical materials for bone repair

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