“…Since some cancer cells have been shown to exhibit limited permissivity due to the low expression of CAR [78], Ad provides an example of a viral vector that may benefit from such modifications with CPPs. A number of studies [44,45,47,50,52,55,56,57,58,59,60,61,62,63,65,66,68,69,70,71,73] have demonstrated that CPPs are able to greatly enhance the transduction of tumor cells derived from a broad range of tissues.…”