Intracellular cytokine production and cognition in healthy older adults

Simpson, E.; Hodkinson, Claire F.; Maylor, Elizabeth A.; McCormack, Jacqueline; Rae, Gordon; Strain, Sean; Alexander, H. Denis; Wallace, Julie

doi:10.1016/j.psyneuen.2013.04.007

Cited by 33 publications

(20 citation statements)

References 48 publications

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“…There is extensive evidence that IL-6, as a proinflammatory cytokine, may affect brain function and may be involved in pathological neurodegenerative disorders. Studies have reported a positive association between plasma IL-6 level and impairment in a wide range of cognitive domains in humans (Gimeno et al, 2008; Simpson et al, 2013; Heringa et al, 2014). Meanwhile, IL-6 overexpression in the brain of transgenic mice has been shown to cause severe neurological disease (Heyser et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

Shen

Wen

et al. 2017

Front. Pharmacol.

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Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function and induce psychotic states. Neuroinflammation has been suggested to play an important role in neurodegeneration. Meanwhile, ketamine has been shown to modulate the levels of inflammatory cytokines. We hypothesized that the effects of ketamine on the central nervous system are associated with inflammatory cytokines. Therefore, we set out to establish acute and chronic ketamine administration models in C57BL/6 mice, to evaluate spatial recognition memory and emotional response, to analyze the changes in the levels of the inflammatory cytokines interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in the mouse hippocampus, employing behavioral tests, Western blot, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry. Our results showed that ketamine at the dose of 60 mg/kg induced spatial recognition memory deficit and reduced anxiety-like behaviors in mice after chronic administration. Moreover, we found that ketamine increased the hippocampal levels of IL-6 and IL-1β after single, multiple and long-term administration in a dose-dependent manner. However, the expression level of TNF-α differed in the mouse hippocampus under different conditions. Single administration of ketamine increased the level of TNF-α, whereas multiple and long-term administration decreased it significantly. We considered that TNF-α expression could be controlled by a bi-directional regulatory pathway, which was associated with the dose and duration of ketamine administration. Our results suggest that the alterations in the levels of inflammatory cytokines IL-6, IL-1β, and TNF-α may be involved in the neurotoxicity of ketamine.

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Section: Discussionmentioning

confidence: 99%

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

Shen

Wen

et al. 2017

Front. Pharmacol.

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“…In another study, it was reported that a higher intracellular cytokine production of IL-1β and IL-6 by activated monocytes was predictive of lower cognitive performance in working memory in healthy older individuals aged 55-70 years [106]. In a prospective population-based cohort study with data collected over 20 years, it was reported that higher serum CRP and IL-6 were associated with a likelihood of cognitive impairment [107].…”

Section: Cognitive Functionmentioning

confidence: 99%

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

Panickar¹,

Jewell²

2015

Hormone Molecular Biology and Clinical Investigation

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Aging in humans is associated with chronic low-grade inflammation (systemic), and this condition is sometimes referred to as "inflammaging". In general, canines also age similarly to humans, and such aging is associated with a decline in mobility, joint problems, weakened muscles and bones, reduced lean body mass, cancer, increased dermatological problems, decline in cognitive ability, reduced energy, decreased immune function, decreased renal function, and urinary incontinence. Each of these conditions is also associated with an increase in pro-inflammatory cytokines. An inflammatory state characterized by an increase in pro-inflammatory markers including but not restricted to tumor necrosis factor-α, interleukin-6, IL-1β, and C-reactive protein (CRP) is believed to contribute to or worsen a general decline in biological mechanisms responsible for physical function with aging. Nutritional management of inflammation in aging dogs is important in maintaining health. In particular, natural botanicals have bioactive components that appear to have robust anti-inflammatory effects and, when included in the diet, may contribute to a reduction in inflammation. While there are scientific data to support the anti-inflammatory effects and the efficacy of such bioactive molecules from botanicals, the clinical data are limited and more studies are needed to validate the efficacy of these ingredients. This review will summarize the role of dietary ingredients in reducing inflammatory molecules as well as review the evidence available to support the role of diet and nutrition in reducing chronic low-grade systemic inflammation in animal and human studies with a special reference to canines, where possible.

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“…These include obesity (Miller and Spencer, 2014), HIV infections (Correia et al, 2013;Hilsabeck et al, 2010), healthy older adults (Elderkin-Thompson et al, 2012;Noble et al, 2010;Simpson et al, 2013), chemotherapy (Cheung et al, 2013;Ganz et al, 2013;Kesler et al, 2013), heart failure (Athilingam et al, 2013), RA (Hamed et al, 2012), hepatitis C virus infection (Farag et al, 2011) and bipolar disorder (Bauer et al, 2014;Lotrich et al, 2014).…”

Section: Cognitive and Memory Difficulties And Inflammationmentioning

confidence: 99%

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

Rathbone

Tharmaradinam

Jiang

et al. 2015

Brain, Behavior, and Immunity

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Intracellular cytokine production and cognition in healthy older adults

Cited by 33 publications

References 48 publications

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

Effects of Ketamine on Levels of Inflammatory Cytokines IL-6, IL-1β, and TNF-α in the Hippocampus of Mice Following Acute or Chronic Administration

The beneficial role of anti-inflammatory dietary ingredients in attenuating markers of chronic low-grade inflammation in aging

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

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