Intracellular Correlates of Fast (&gt;200 Hz) Electrical Oscillations in Rat Somatosensory Cortex

Jones, Michael S.; MacDonald, Kurt D.; Choi, Byung Jin; Dudek, F. Edward; Barth, Daniel S.

doi:10.1152/jn.2000.84.3.1505

Cited by 172 publications

(141 citation statements)

References 54 publications

(49 reference statements)

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“…The amplitude of high-frequency oscillations of the somatosensory cortex range between 10 and 100 V (Kandel and Buzsaki, 1997;Jones et al, 2000), whereas the amplitude of ripples in the hippocampal-entorhinal circuitry range from 100 to 500 V (Buzsaki et al, 1992;Ylinen et al, 1995;Chrobak and Buzsaki, 1996). In our experiments, the FR amplitude varied between 0.1 and 1.5 mV.…”

Section: Discussionmentioning

confidence: 60%

“…In experiments searching for cellular correlates of very fast oscillations with the center frequency near 300 Hz in rat somatosensory cortex, no specific cell population could be found with oscillations in this frequency band, although some individual interneurons fired in synchrony with very fast oscillations (Jones et al, 2000). These fast oscillations were thought to be produced by local circuit interactions of both synaptic and gap junctional origin.…”

Section: Discussionmentioning

confidence: 99%

“…In the neocortex of humans and animals, oscillations in the FR range are part of the sensory-evoked response (Curio, 2000;Jones et al, 2000). In experiments searching for cellular correlates of very fast oscillations with the center frequency near 300 Hz in rat somatosensory cortex, no specific cell population could be found with oscillations in this frequency band, although some individual interneurons fired in synchrony with very fast oscillations (Jones et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…High-frequency oscillations in the frequency range of 100 -600 Hz indicate a short-term synchronization of neuronal ensembles (Buzsaki et al, 1992;Curio, 2000;Jones et al, 2000;Grenier et al, 2001). In primary sensory areas, these oscillations occur during the acquisition of sensory information, whereas in the hippocampal-entorhinal circuitry, they occur during immobility and/or slow wave sleep.…”

Section: Abstract: Hippocampus; Entorhinal Cortex; Chronic Seizures;mentioning

confidence: 99%

“…In primary sensory areas, these oscillations occur during the acquisition of sensory information, whereas in the hippocampal-entorhinal circuitry, they occur during immobility and/or slow wave sleep. In sensory systems, the high-frequency oscillations reflect coherent discharges of neurons in response to incoming sensory events (Curio, 2000;Jones et al, 2000) and are generated as a result of sequential and recurrent propagation of action potentials throughout the principal cell population (Kandel and Buzsaki, 1997;Jones et al, 2000). Two mechanisms of high-frequency oscillation generation have been proposed in the hippocampus.…”

Section: Abstract: Hippocampus; Entorhinal Cortex; Chronic Seizures;mentioning

confidence: 99%

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Local Generation of Fast Ripples in Epileptic Brain

et al. 2002

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Aperiodic high-frequency oscillations (Ͼ100 Hz) reflect a shortterm synchronization of neuronal electrical activity. It has been shown in the epileptic brain that spontaneous oscillations in the frequency range of 250-600 Hz reflect action potential population bursts of synchronously discharging neuronal clusters. These oscillations occur in the early stages of epileptogenesis in areas adjacent to the brain lesion and may trigger the formation of seizure-generating neuronal networks. We studied the extent of the area generating oscillations in the frequency range of 250-600 Hz [fast ripples (FRs)] in intrahippocampal kainic acid-treated rats with spontaneous seizures, by analyzing voltage versus depth profiles of FRs in hippocampal and parahippocampal areas in freely moving animals and by spatial mapping in hippocampal slice preparations in vitro. The strength of inhibition was compared in areas with and without FRs using a paired-pulse paradigm. The extent of the areas generating FRs did not exceed 1 mm 3 . The areas generating FRs became broader after the application of the GABA A receptor antagonist bicuculline. Paired-pulse fast inhibition at 15-30 msec intervals was similar in areas generating FRs and areas not generating FRs. Our data illustrate that hypothesized clusters of highly interconnected neurons are capable of overcoming interneuron feedback inhibition, resulting in generation of epileptiform bursts, eventually leading to seizure activity.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Abstract: Hippocampus; Entorhinal Cortex; Chronic Seizures;mentioning

confidence: 99%

Section: Abstract: Hippocampus; Entorhinal Cortex; Chronic Seizures;mentioning

confidence: 99%

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Local Generation of Fast Ripples in Epileptic Brain

et al. 2002

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High‐frequency oscillations recorded in human medial temporal lobe during sleep

Staba

Wilson

Bragin

et al. 2004

Annals of Neurology

300

272

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The presence of fast ripple oscillations (FRs, 200-500 Hz) has been confirmed in rodent epilepsy models but has not been observed in nonepileptic rodents, suggesting that FRs are associated with epileptogenesis. Although studies in human epileptic patients have reported that both FRs and ripples (80-200 Hz) chiefly occur during non-rapid eye movement sleep (NREM), and that ripple oscillations in human hippocampus resemble those found in nonprimate slow wave sleep, quantitative studies of these oscillations previously have not been conducted during polysomnographically defined sleep and waking states. Spontaneous FRs and ripples were detected using automated computer techniques in patients with medial temporal lobe epilepsy during sleep and waking, and results showed that the incidence of ripples, which are thought to represent normal activity in animal and human hippocampus, was similar between epileptogenic and nonepileptogenic temporal lobe, whereas rates of FR occurrence were significantly associated with epileptogenic areas. The generation of both FRs and ripples showed the highest rates of occurrence during NREM sleep. During REM sleep, ripple rates were lowest, whereas FR rates remained elevated and were equivalent to rates observed during waking. The predominance of FRs within the epileptogenic zone not only during NREM sleep, but also during epileptiform-suppressing desynchronized episodes of waking and REM sleep supports the view that FRs are the product of pathological neuronal hypersynchronization associated with seizure-generating areas.

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Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Gierthmuehlen

Wang

Gkogkidis

et al. 2014

J of Comparative Neurology

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Microelectrocorticography (µECoG) provides insights into the cortical organization with high temporal and spatial resolution desirable for better understanding of neural information processing. Here we evaluated the use of µECoG for detailed cortical recording of somatosensory evoked potentials (SEPs) in an ovine model. The approach to the cortex was planned using an MRI-based 3D model of the sheep's brain. We describe a minimally extended surgical procedure allowing placement of two different µECoG grids on the somatosensory cortex. With this small craniotomy, the frontal sinus was kept intact, thus keeping the surgical site sterile and making this approach suitable for chronic implantations. We evaluated the procedure for chronic implantation of an encapsulated µECoG recording system. During acute and chronic recordings, significant SEP responses in the triangle between the ansate, diagonal, and coronal sulcus were identified in all animals. Stimulation of the nose, upper lip, lower lip, and chin caused a somatotopic lateral-to-medial, ipsilateral response pattern. With repetitive recordings of SEPs, this somatotopic pattern was reliably recorded for up to 16 weeks. The findings of this study confirm the previously postulated ipsilateral, somatotopic organization of the sheep's sensory cortex. High gamma band activity was spatially most specific in the comparison of different frequency components of the somatosensory evoked response. This study provides a basis for further acute and chronic investigations of the sheep's sensory cortex by characterizing its exact position, its functional properties, and the surgical approach with respect to macroanatomical landmarks.

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Intracellular Correlates of Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex

Cited by 172 publications

References 54 publications

Local Generation of Fast Ripples in Epileptic Brain

Local Generation of Fast Ripples in Epileptic Brain

High‐frequency oscillations recorded in human medial temporal lobe during sleep

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

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