Intracellular and plasma cytokine profile in neonates born to non-atopic parents: the impact of breast feeding

Kanakoudi-Tsakalidou, F; Drossou-Agakidou, V; Noutsia, Chariklia; Tzimouli, Vasiliki; Ταπάρκου, Άννα; Mavridis, Panagiotis; Kremenopoulos, George

doi:10.1007/s00431-004-1463-4

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…We could not find any significant differences between those cell surface markers at 26 wk. In accordance with our data, Kanakoudi-Tsakalidou et al did not find a difference in the plasma levels of IL-4 and IFN-c between exclusively breast fed and formula fed infants at the age of 1 month (26).…”

Section: Discussionsupporting

confidence: 93%

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Exploration of basal immune parameters in healthy infants receiving an infant milk formula supplemented with prebiotics

Raes¹,

Scholtens

Alliet³

et al. 2010

Pediatric Allergy Immunology

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This double-blind, randomized, placebo-controlled study, aimed to explore the effect of an infant milk formula (IMF) with 6 g/l short-chain galacto- and long-chain fructo-oligosaccharides (scGOS/lcFOS, ratio 9:1) on basal immune parameters in 215 healthy, term infants during the first 26 wk of life. After birth, the infants received breast milk or were randomized to receive an IMF with or without scGOS/lcFOS. Blood samples were collected at the age of 8 wk and 26 wk for the analysis of serum immunoglobulins, lymphocyte subpopulations, and cytokines. The scGOS/lcFOS group and the control group were compared in the statistical analysis. A breast fed group was included as a reference. In total, 187 Infants completed the study. No significant differences were observed between both formula groups in the different studied immune parameters at weeks 8 and 26. This explorative study indicates that supplementation of infant formula with a mixture of prebiotic oligosaccharides did not change the basal level of the measured parameters of the developing immune system in healthy infants with a balanced immune system during the first 6 months of life in comparison to feeding a standard infant formula and in comparison to exclusive breastfeeding.

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Section: Discussionsupporting

confidence: 93%

“…In accordance with our data, Kanakoudi‐Tsakalidou et al. did not find a difference in the plasma levels of IL‐4 and IFN‐γ between exclusively breast fed and formula fed infants at the age of 1 month (26).…”

Section: Discussionsupporting

confidence: 92%

Exploration of basal immune parameters in healthy infants receiving an infant milk formula supplemented with prebiotics

Raes¹,

Scholtens

Alliet³

et al. 2010

Pediatric Allergy Immunology

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show abstract

“…This result is similar to a recent cohort study from Copenhagen Prospective Study on Asthma which showed that breastfeeding does not protect against allergic sensitization in early childhood and allergy-associated disease at age 7 years [24]. Another cohort study from Japan also found that breastfeeding, whether exclusive or not, was not significantly correlated to protection from wheezing and asthma [25].…”

Section: Discussionsupporting

confidence: 87%

A prospective birth cohort study of different risk factors for development of allergic diseases in offspring of non-atopic parents

Lee

et al. 2017

Oncotarget

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Background: Allergic diseases are thought to be inherited. Prevalence of allergic diseases has, however, increased dramatically in last decades, suggesting environmental causes for the development of allergic diseases.Objective: We studied risk factors associated with the development of atopic dermatitis (AD), allergic rhinitis (AR) and asthma (AS) in children of non-atopic parents in a subtropical country.Methods: In a birth cohort of 1,497 newborns, parents were prenatally enrolled and validated for allergic diseases by questionnaire, physician-verified and total or specific Immunoglobulin E (IgE) levels; 1,236 and 756 children, respectively, completed their 3-year and 6-year follow-up. Clinical examination, questionnaire, and blood samples for total and specific IgE of the children were collected at each follow-up visit.Results: Prevalence of AD, AR and AS was, respectively, 8.2%, 30.8% and 12.4% in children of non-atopic parents. Prevalence of AR (p<.001) and AS (p=.018) was significantly higher in children of parents who were both atopic. A combination of Cesarean section (C/S) and breastfeeding for more than 1 month showed the highest risk for AD (OR=3.111, p=.006). Infants living in homes with curtains and no air filters had the highest risk for AR (OR=2.647, p<.001), and male infants of non-atopic parents living in homes without air filters had the highest risk for AS (OR=1.930, p=.039).Conclusions: Breastfeeding and C/S affect development of AD. Gender, use of curtains and/or air filters affect AR and AS, suggesting that control of the perinatal environment is necessary for the prevention of atopic diseases in children of non-atopic parents.

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“…Due to limited sample volume and the retrospective nature of the study, T cell-mediated immunity was assessed by measuring serum cytokine levels using a multiplex microarray assay. Table 4 tabulates the cytokine levels in the neonatal and maternal groups as well as showing the reference ranges for these cytokines published previously in healthy neonates and adults [13][14][15][16][17][18][19][20][21][22][23][24][25]. Although maternal sera had higher levels of IFN-g than paired neonatal sera, statistical significance was not reached.…”

Section: Serum Cytokine Levels In Response To CMVmentioning

confidence: 99%

Immunological response to cytomegalovirus in congenitally infected neonates

Hassan

Dooley

Hall

2007

Clinical and Experimental Immunology

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Cytomegalovirus (CMV) is the most common cause of congenital infection worldwide and occurs as a result of transplacental transmission of the virus. The human neonate is highly susceptible to infection due to a combination of immaturity of the immune system and antigenic inexperience. This study uses the in vivo model of congenital CMV to examine both the humoral and cell-mediated immune responses in vertically infected neonates and their mothers. Ten pairs of matched neonates and their mothers were evaluated for specific IgM responses to three immunodominant CMV antigens: pp38 (pUL80a), pp52 (pUL44) and pp150 (pUL32). In contrast to conventional enzyme immunoassay (EIA) testing for CMV-specific IgM, which found five of the mothers and four of the neonates to be positive, Western immunoblotting showed all 10 adults and nine newborns to be positive. Eight mothers and nine newborns had serological evidence of primary infection. All neonates showed a response to pp38, an assembly protein, nine responded to the pp52 immediate early antigen but only four had reactivity to the pp150 tegument associated protein. Of the mothers, eight had pp38 reactivity, 10 showed a response to the pp52 antigen and seven to the pp150 antigen. T cell-mediated immunity was assessed by measuring cytokines using a multiplex microarray assay. Levels of interferon (IFN)-gamma were high in both groups [mean +/- standard error of the mean (s.e.m.): neonates = 657 +/- 238 pg/ml, mothers = 1072 +/- 677 pg/ml, pNS]; however, neonates had significantly higher levels of interleukin (IL)-8 (316 +/- 136 pg/ml versus 48 +/- 28 pg/ml, P < 0.005). Similar levels of IL-2, IL-7, IL-10 and IL-12 were measured in both groups, but levels of IL-1alpha, IL-1beta, IL-4, IL-6 and tumour necrosis factor (TNF)-alpha were either absent or low. In response to CMV, neonates and adults mount a predominant T helper 1 (Th1) response, as evidenced by the presence of IL-2, IL-8, IL-12 and IFN-gamma with concomitant lack of IL-4. These findings suggest that the neonate, when presented with infection in utero, is capable of mounting an individual response; however, the lower IFN-gamma and higher IL-8 levels suggest reduced immune responsiveness when compared to their adult counterparts.

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Intracellular and plasma cytokine profile in neonates born to non-atopic parents: the impact of breast feeding

Cited by 8 publications

References 34 publications

Exploration of basal immune parameters in healthy infants receiving an infant milk formula supplemented with prebiotics

Exploration of basal immune parameters in healthy infants receiving an infant milk formula supplemented with prebiotics

A prospective birth cohort study of different risk factors for development of allergic diseases in offspring of non-atopic parents

Immunological response to cytomegalovirus in congenitally infected neonates

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